Safety of vitamin D3 in adults with multiple sclerosis

Kimball, Samantha; Ursell, Melanie R.; O’Connor, PW; Vieth, Reinhold

doi:10.1093/ajcn/86.3.645

Cited by 204 publications

(164 citation statements)

References 43 publications

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“…A few studies indicate that treatment with vitamin D could be beneficial as well in reducing the risk of developing MS and diminishing exacerbations of MS in affected patients [37;38]. In addition, a small 28-week trial in which MS patients received 28,000 to 280,000 IU/week provided evidence that high-dose vitamin D supplementation is safe in these patients [39]. Although contradictory data exist concerning supplementation benefits in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), an association between low levels of 25(OH)D and SLE disease activity [40] or RA disease activity [41] has recently been shown.…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Souberbielle¹,

Body

Lappe

et al. 2010

Autoimmunity Reviews

496

375

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Background: There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases.An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations.Methods: Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Results and conclusion:Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and

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Section: Vitamin D and The Immune Systemmentioning

confidence: 99%

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Souberbielle¹,

Body

Lappe

et al. 2010

Autoimmunity Reviews

496

375

View full text Add to dashboard Cite

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“…One small safety study of 12 patients taking 1000 g per day (40,000 IU) of vitamin D for 28 weeks showed a decline in the number of gadolinium-enhancing lesions on magnetic resonance imaging per patient; this led to a 25(OH)D serum concentration of 386 nmol/L (158 ng/mL) without causing hypercalcemia, hypercalciuria, or other complication. 43 …”

Section: Vitamin D and Multiple Sclerosismentioning

confidence: 99%

Vitamin D: An Evidence-Based Review

Kulie

Groff²,

Redmer³

et al. 2009

The Journal of the American Board of Family Medicine

289

180

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“…However, the abundance of studies pointing at association of low vitamin D concentration and MS advocate for the beneficial role of vitamin D supplements as prophylactic and/or treatment agents. Clinical studies have indicated that large doses of 25(OH)D [79] and 1,25(OH)D [80] supplements are safe and well tolerated by MS patients. Even though disease progression and activity were not altered by 25(OH)D, the vitamin supplementation lead to reduction in gadolinium-enhancing lesions per patient as described by Kimball et al [79].…”

Section: Vitamin Dmentioning

confidence: 99%

“…Clinical studies have indicated that large doses of 25(OH)D [79] and 1,25(OH)D [80] supplements are safe and well tolerated by MS patients. Even though disease progression and activity were not altered by 25(OH)D, the vitamin supplementation lead to reduction in gadolinium-enhancing lesions per patient as described by Kimball et al [79]. The therapeutic effects of vitamin D supplements are currently being further investigated.…”

Section: Vitamin Dmentioning

confidence: 99%

Environmental triggers of multiple sclerosis

Kakalacheva

Lünemann

2011

FEBS Letters

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a b s t r a c tMultiple sclerosis is a chronic immune-mediated disease of the central nervous system that develops in young adults with a complex genetic predisposition. Similar to other autoimmune disease, HLA-DR and -DQ alleles within the HLA class II region on chromosome 6p21 are by far the strongest risk-conferring genes. Less robust susceptibility effects have been reported for non-MHC related genetic variants. Improvements in the design of epidemiological studies helped to identify consistent environmental risk-associations such as the increased susceptibility for MS in individuals with a history of infectious mononucleosis, a symptomatic primary infection with the human c-herpesvirus Epstein-Barr virus (EBV). Sun exposure and serum vitamin D levels are emerging non-infectious environmental risk factors that may have independent roles. The analysis of environmental effects will likely expand in the next few years and will allow for the generation of testable hypotheses as to how environmental insults interact with genetic factors to jointly determine the susceptibility to MS. Insights gained from these studies might facilitate the development of prevention strategies and more effective treatments for MS.

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Safety of vitamin D3 in adults with multiple sclerosis

Cited by 204 publications

References 43 publications

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Vitamin D: An Evidence-Based Review

Environmental triggers of multiple sclerosis

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