Sage oil extraction and optimization by response surface methodology

Akalın, Mehmet Kuddusi; Tekin, Kubilay; Akyüz, Mehmet; Karagöz, Selhan

doi:10.1016/j.indcrop.2015.08.005

Cited by 29 publications

(18 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Then, response surface methodology (RSM) should be conducted to maximize the extraction yield as a statistical multi-response optimization method. RSM is an effective statistic tool with minimized experimental trials and a 3D description of the interactions of parameters [18,26]. …”

Section: Introductionmentioning

confidence: 99%

Extraction of Natural Antioxidants from the Thelephora ganbajun Mushroom by an Ultrasound-Assisted Extraction Technique and Evaluation of Antiproliferative Activity of the Extract against Human Cancer Cells

Zheng

Zhou

et al. 2016

IJMS

View full text Add to dashboard Cite

The Thelephora ganbajun mushroom has been found to be a potential rich source of natural antioxidants. In this study, an ultrasound-assisted extraction (UAE) technique together with GRAS (generally recognized as safe) solvents (ethanol and water) was used to maximize the extraction of antioxidants from Thelephora ganbajun. Five extraction parameters (ethanol concentration, solvent to solid ratio, extraction time, temperature and ultrasound power) were investigated by single-factor experiments, and then a central composite rotatable design was employed to study interaction of three key extraction parameters. The optimum conditions were as follows: 57.38% ethanol, 70.15 mL/g solvent to solid ratio, 10.58 min extraction time, 40 °C extraction temperature and 500 W ultrasound power. Under the optimum conditions, the antioxidant activity obtained was 346.98 ± 12.19 µmol Trolox/g DW, in accordance with the predicted value of 344.67 µmol Trolox/g DW. Comparison of UAE with conventional maceration and Soxhlet extraction, the UAE method showed stronger extract efficiency in a shorter extraction time. These results showed that UAE was an effective technique to extract antioxidants from Thelephora ganbajun. Furthermore, the extracts obtained under the optimized conditions exhibited antiproliferative activities toward human lung (A549), breast (MCF-7), liver (HepG2) and colon (HT-29) cancer cells, especially for liver and lung cancer cells. In addition, rutin, 2-hydrocinnamic acid and epicatechin were identified in the extract, which might contribute to antioxidant and antiproliferative activities.

show abstract

Section: Introductionmentioning

confidence: 99%

Extraction of Natural Antioxidants from the Thelephora ganbajun Mushroom by an Ultrasound-Assisted Extraction Technique and Evaluation of Antiproliferative Activity of the Extract against Human Cancer Cells

Zheng

Zhou

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…Moreover, the RSM analysis of CUPRAC values showed that the model was significant with p-value < 0.0001, did not present lack of fit (p = 0.2818) and could explain 92.73 % of calculated model (adjusted R² = 0.9074). In addition to that, the coefficient of variation (CV) equal to 1.84 %, demonstrates the high degree of precision between the calculated and experimental results [26], and the adequate precision is 16.06 as well.…”

Section: Tfc Yx =-mentioning

confidence: 81%

“…They indicate that the model is more accurate and fits the data [25]. The coefficient of variation (CV) is equal to 4.91 %, indicating the high degree of precision between the calculated and experimental result [26]. Withal, the adequate precision measures the signal to noise ratio and this ratio was 9.29.…”

Section: Optimization Of Extractionmentioning

confidence: 92%

Microcrystalline Cellulose from Groundnut Shell as Potential Adsorbent of Crystal Violet and Methylene Blue. Kinetics, Isotherms and Thermodynamic Studies

Zango¹,

Imam²

2020

ChChT

View full text Add to dashboard Cite

show abstract

“…the model, For a good adjustment of a model, the R 2 value should be a minimum of 0.80 [39]. Alternatively, a coefficient of variation (CV) of 5.9% indicates a very high degree of precision between the experimental and predicted values [12].…”

Section: Statistical Validation Of the Modelmentioning

confidence: 99%

“…In the framework of improving essential oil yield, studies have been conducted on the optimization of extraction operating parameters through the use of the response surface methodology (RSM) [7][8][9][10][11][12]. The objective of the study of the response surfaces is to model the studied phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Green-extraction of essential oil of the species Ruta chalepensis L.: gas chromatography-mass spectroscopy-infra red analysis and response surface methodology optimization

Djermane

Abidi

Chrouda

et al. 2019

Acta Scientifica Naturalis

View full text Add to dashboard Cite

The objective of the present study was the optimization of the parameters affecting the hydrodistillation of Ruta chalepensis L. essential oil using response surface design type Box-Behnken. After an appropriate choice of three parameters, 15 experiments were performed leading to a mathematical second-degree model relating the response function (yield of essential oil) to parameters and allowing a good control of the extraction process. The realization of the experiments and data analysis was carried out by response surface methodology (RSM). A deduced second-order polynomial expression was used to determine the optimal conditions necessary to obtain a better essential oil yield. These optimized operating conditions were: a granulometry of 2 mm, a condensation-water flow rate of 3.4 mL/min and an extraction time of 204 min. Analysis of variance (ANOVA) indicates that the generated second-order polynomial model was highly significant with R2=0.9589 and P<0.006. The gas chromatography-mass spectrometry analysis of essential oil extracted from the Ruta chalepensis L. aerial parts revealed the presence of 2-undecanone, 2-nonanone and 2-decanone as major components.

show abstract

Sage oil extraction and optimization by response surface methodology

Cited by 29 publications

References 22 publications

Extraction of Natural Antioxidants from the Thelephora ganbajun Mushroom by an Ultrasound-Assisted Extraction Technique and Evaluation of Antiproliferative Activity of the Extract against Human Cancer Cells

Extraction of Natural Antioxidants from the Thelephora ganbajun Mushroom by an Ultrasound-Assisted Extraction Technique and Evaluation of Antiproliferative Activity of the Extract against Human Cancer Cells

Microcrystalline Cellulose from Groundnut Shell as Potential Adsorbent of Crystal Violet and Methylene Blue. Kinetics, Isotherms and Thermodynamic Studies

Green-extraction of essential oil of the species Ruta chalepensis L.: gas chromatography-mass spectroscopy-infra red analysis and response surface methodology optimization

Contact Info

Product

Resources

About