Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice

Du, Zhi-An; Sun, Meina; Hu, Zhansheng

doi:10.1007/s10753-017-0677-3

Cited by 75 publications

(37 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Saikosaponins, an oleanane-type triterpenoid saponins, is the major bioactive ingredient extracted from Radix bupleuri , which has been used to prevent Alzheimer’s, pulmonary diseases, and even viral hepatitis [ 59 , 60 , 61 ]. However, in accordance with the cumulative evidence, saikosaponins probably contributed to toxicity in hepatocytes, and in particular, caused acute liver injury with doses of more than 19 g/day for a human being with 70 kg body weight.…”

Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning

confidence: 99%

“…Aside from that, the ethanol extract is more toxic than the aqueous extract [ 89 ]. A method of prolonged decoction was convincingly demonstrated to effectively detoxicate Polygonum multiflorum [ 59 ]. Based on these alterations in biomarkers, Polygonum multiflorum -induced disturbance in the metabolic process of fat, bile acid, and amino acid may be the dominant threats to the induction of oxidative hepatotoxicity.…”

Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning

confidence: 99%

See 1 more Smart Citation

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

Zhang

Wang

et al. 2018

IJMS

View full text Add to dashboard Cite

Oxidative stress, defined as a disequilibrium between pro-oxidants and antioxidants, can result in histopathological lesions with a broad spectrum, ranging from asymptomatic hepatitis to hepatocellular carcinoma in an orchestrated manner. Although cells are equipped with sophisticated strategies to maintain the redox biology under normal conditions, the abundance of redox-sensitive xenobiotics, such as medicinal ingredients originated from herbs or animals, can dramatically invoke oxidative stress. Growing evidence has documented that the hepatotoxicity can be triggered by traditional Chinese medicine (TCM) during treating various diseases. Meanwhile, TCM-dependent hepatic disorder represents a strong correlation with oxidative stress, especially the persistent accumulation of intracellular reactive oxygen species. Of note, since TCM-derived compounds with their modulated targets are greatly diversified among themselves, it is complicated to elaborate the potential pathological mechanism. In this regard, data mining approaches, including network pharmacology and bioinformatics enrichment analysis have been utilized to scientifically disclose the underlying pathogenesis. Herein, top 10 principal TCM-modulated targets for oxidative hepatotoxicity including superoxide dismutases (SOD), malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS), glutathione peroxidase (GPx), Bax, caspase-3, Bcl-2, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and nitric oxide (NO) have been identified. Furthermore, hepatic metabolic dysregulation may be the predominant pathological mechanism involved in TCM-induced hepatotoxic impairment.

show abstract

Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning

confidence: 99%

Section: Molecular Mechanisms Involved In Tcm-induced Oxidative Hementioning

confidence: 99%

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

Zhang

Wang

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…The animal grouping strategy used in the current study was similar to a previous study (26). The dose of SSa administrated in the current study was determined according to a previous publication (16). SSa was administrated by intraperitoneal injection 1 h before inducing HP.…”

Section: Methodsmentioning

confidence: 99%

“…Emerging evidence has suggested that SSs display anti-inflammatory, antiviral, antioxidant, antitumor, immune regulatory and central nervous system protective effects (13,15). Among the SSs, SSa has attracted considerable attention due to its significant anti-inflammatory activity (16). Direct inhibition of proinflammatory cytokine expression and regulation of the inflammatory response via specific signaling pathways, such as the NF-κB signaling pathway, have been identified as critical mechanisms underlying the anti-inflammatory activity of SSa (17).…”

Section: Introductionmentioning

confidence: 99%

Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR‑γ/NF‑κB signaling pathway

Feng

Tong

et al. 2019

Exp Ther Med

View full text Add to dashboard Cite

The therapeutic effect of saikosaponin a (SSa) on hyperlipidemic pancreatitis (HP) is not completely understood. The aim of the present study was to investigate the therapeutic effect and the underlying mechanism of SSa using a rat model of HP. Following successful establishment of the HP rat model, different doses of SSa (low dose group, 10 mg/kg or high dose group, 20 mg/kg) were administrated. Histopathological examination, the wet/dry (W/D) ratio and myeloperoxidase (MPO) activity of the pancreatic tissues were assessed. The lipid, amylase (AMY), lipase and proinflammatory cytokine profiles in serum, as well as the expression of peroxisome proliferator-activated receptor (PPAR)-γ and the NF-κB signaling pathway-related proteins in pancreatic tissues were evaluated. The results showed that SSa effectively attenuated pancreatic pathological injury and reduced both the W/D ratio and MPO activity compared to the HP model rats. SSa also improved lipid metabolism by significantly decreasing the serum levels of total cholesterol and triglycerides (P<0.05). Following the administration of SSa, the activity of AMY and lipase, as well as the levels of the proinflammatory cytokines tumor necrosis factor-α, interleukin (IL)-1β and IL-6 were reduced, particularly in the high dosage group (P<0.05). Furthermore, SSa activated PPAR-γ expression and suppressed the NF-κB signaling pathway in pancreatic tissues. The present study suggested that SSa attenuated HP in rats by increasing lipid metabolism and inhibiting the release of proinflammatory cytokines via the NF-κB inflammatory pathway. The results from the present study indicated that SSa might be a promising therapeutic agent for the treatment of HP.

show abstract

“…SSa also inhibits IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by activating LXRα signaling (Gao et al, 2017), and inhibits LPS-induced production of reactive oxygen species (ROS), TNFα and IL-8 through the suppression of LPS-induced toll-like receptor 4 (TLR4) activation (Fu et al, 2015). In LPS-induced acute lung injury mice model, SSa reduced pathological injury via inhibiting TNFα and IL-1β and suppressing the NLR family pyrin domain containing 3 (NLRP3) inflammasome function (Du et al, 2017). Previous studies also demonstrated that SSa protects rats from carbon tetrachloride (CCl 4 )-induced liver injury and controls cortical impact-induced traumatic brain injury by suppressing hepatic inflammation and neural inflammation, respectively (Mao et al, 2016;Wu et al, 2010).…”

Section: Effects Of Sss On Inflammationmentioning

confidence: 99%

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

Huang

et al. 2018

Phytomedicine

145

View full text Add to dashboard Cite

Background: Radix Bupleuri (RB) has been widely used in Chinese Traditional Medicine for over 2000 years and is currently marketed in China as Chai-Hu-Shu-Gan tablets and Xiao-Yao-Wan tablets. Saikosaponins (SSs, especially SSa, SSc and SSd), as the major bioactive compounds in RB, represent anti-inflammatory, anti-tumor, anti-oxidant, anti-viral and hepatoprotective effects. Purpose: To summarize recent findings regarding to the extraction, detection, biosynthesis, metabolism, pharmacological/toxicological effects of SSs. Methods: Online academic databases (including PubMed, Google Scholar, Web of Science and CNKI) were searched using search terms of "Saikosaponin", "Radix Bupleuri", "Bupleurum" and combinations to include published studies of SSs primarily from 2003 to 2018. Several critical previous studies beyond this period were also included. Results: 354 papers were found and 165 papers were reviewed. SSs have drawn great attention for their antiinflammation, anti-viral and anti-cancer effects and contradictory roles in the regulation of cell apoptosis, oxidative stress and liver fibrosis. Meanwhile, increased risks of overdose-induced acute or accumulation-related chronic hepatotoxicity of SSs and RB have also been reported. However, underlying mechanisms of SSs bioactivities, the metabolism of SSs and bioactivities of SSs metabolites are largely unknown. Conclusion: This comprehensive review of SSs provides novel insights and perspectives on the limitations of current studies and the importance of metabolism study and the dose-pharmacological/toxic relationship of SSs for the future discovery of SSs-based therapeutic strategies and clinical safe practice.

show abstract

Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice

Cited by 75 publications

References 31 publications

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

Saikosaponin a attenuates hyperlipidemic pancreatitis in rats via the PPAR‑γ/NF‑κB signaling pathway

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

Contact Info

Product

Resources

About