Salbutamol and the Conditioning of Latissimus Dorsi for Cardiomyoplasty

Wright, Leon D.; Zhang, K.-M.; McClain, Lucinda; Hsia, Peng-Wie; Briggs, F. Norman; Spratt, John A.

doi:10.1006/jsre.1998.5507

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…There have been other approaches to the restoration of the distal blood supply. These include a true vascular delay of 10–18 days prior to mobilization of the muscle,3, 4, 9, 15 and the use of pharmacological agents such as salbutamol,37 vasodilators,31, 33 and angiogenic growth factors 8, 19…”

Section: Discussionmentioning

confidence: 99%

“…There have been other approaches to the restoration of the distal blood supply. These include a true vascular delay of 10-18 days prior to mobilization of the muscle, 3,4,9,15 and the use of pharmacological agents such as salbutamol, 37 vasodilators, 31,33 and angiogenic growth factors. 8,19 There is an increasing body of evidence to show that blood flow to the distal region of the LDM is enhanced by electrical prestimulation and that this effect persists after mobilization.…”

Section: Discussionmentioning

confidence: 99%

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Improved viability of latissimus dorsi muscle grafts after electrical prestimulation

et al. 2002

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Surgical mobilization of the latissimus dorsi muscle (LDM) produces fiber degeneration, particularly in the distal part of the graft, that may compromise its function in clinical applications such as dynamic cardiomyoplasty. In five rats, the left LDM was stimulated continuously at 10 HZ. After 5 weeks, vessels perforating the chest wall were divided and the left LDM was mobilized as a pedicle graft based on the thoracodorsal artery. Twenty-four hours later, animals were killed and left and right LDMs were incubated with the vital stain nitroblue tetrazolium. Five control rats underwent a similar procedure without prestimulation. Mobilization of the LDM resulted in a loss of viability in the distal third of the muscle graft. This was reduced significantly by prestimulation (P = 0.006). Blood flow to the distal LDM graft is known to be augmented by electrical stimulation in situ before mobilization; the present results show that there is an associated enhancement of viability. The clinical implications of this finding are discussed.

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