Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise

Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol

“…SAL lowered venous [K ϩ ] by 0.3-0.8 mM at rest (29) and during intense cycling exercise (18,28,36). SAL inhalation reduced the rise in [K ϩ ] a by~0.5 mM during intense continuous exercise but not during repeated brief sprints (5). Ter-butaline inhalation lowered venous [K ϩ ] by~0.5 mM at rest and by~0.3 mM immediately after completion of sprint exercise (37), whereas intravenous terbutaline infusion decreased [K ϩ ] a and venous [K ϩ ] at rest by~0.8 mM and during two-legged knee extension exercise by~0.7-0.9 mM (31).…”

“…Ter-butaline inhalation lowered venous [K ϩ ] by~0.5 mM at rest and by~0.3 mM immediately after completion of sprint exercise (37), whereas intravenous terbutaline infusion decreased [K ϩ ] a and venous [K ϩ ] at rest by~0.8 mM and during two-legged knee extension exercise by~0.7-0.9 mM (31). However, much less is known about possible postexercise [K ϩ ]-lowering effects of ␤ 2 agonists, with previous findings conflicting (5,31,36) and with further study required. We recently reported a systematic lowering after SAL in the rise in [K ϩ ] a with intense continuous and subsequent intermittent exercise, which included recovery phases in both (5).…”

“…However, much less is known about possible postexercise [K ϩ ]-lowering effects of ␤ 2 agonists, with previous findings conflicting (5,31,36) and with further study required. We recently reported a systematic lowering after SAL in the rise in [K ϩ ] a with intense continuous and subsequent intermittent exercise, which included recovery phases in both (5). No specific reductions were evident during the final recovery, which was, however, probably affected by the small rise in [K ϩ ] a evident during intermittent exercise (5).…”

“…We recently reported a systematic lowering after SAL in the rise in [K ϩ ] a with intense continuous and subsequent intermittent exercise, which included recovery phases in both (5). No specific reductions were evident during the final recovery, which was, however, probably affected by the small rise in [K ϩ ] a evident during intermittent exercise (5). Interpretation of SAL effects on [K ϩ ] a during early recovery in that study were complicated by inclusion of two exercise types (continuous and intermittent) and the use of an intervening recovery period, at the end of which [K ϩ ] a did not differ between trials (5).…”

A single oral glucose load decreases arterial plasma [K + ] during exercise and recovery

“…However, they did find lower venous [K + ] during exercise after ingesting a mixed beverage pre‐exercise of 8% glucose polymer + fructose + electrolytes (5.7 mM [K + ], 17.8 mM [Na + ]) and then another beverage during exercise of 8% glucose polymer and fructose + glucose + electrolytes (0.8 mM [K + ], 17.8 mM [Na + ]) (Tarnopolsky et al., 1996). Given the large differences reported here between arterial and forearm venous [K + ], the venous [K + ] reported in both these studies (Murray et al., 1987; Tarnopolsky et al., 1996) would have been heavily influenced by the effects of the forearm musculature, which can substantially elevate [K + ] if their activity is not controlled (Sostaric et al., 2006); in addition, forearm venous [K + ] would also be expected to be influenced by adrenergic activity (Altarawneh et al., 2016).…”