Salbutamol in paediatrics: pharmacology, prescribing and controversies

Andrzejowski, Paul; Carroll, Will

doi:10.1136/archdischild-2014-307285

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…The recommended doses for pediatric patients are 4–5 puffs for children < 20 kg and 6–10 puffs for those > 20 kg. Nebulization should be limited to: severe patients <5 years: 2.5 mg/3–4 ml, and >5 years: 5.0 mg/3–4 ml (see Table 2) [[25], [26], [27], [28], [29], [30]]. MDIs and nebulizers are equally effective methods for delivering beta2 agonists to children with acute asthma and mild to moderate exacerbations.…”

Section: Introductionmentioning

confidence: 99%

Management of asthma exacerbation in the emergency departments

Al-Shamrani

Alharbi‎

Bagais

et al. 2019

International Journal of Pediatrics and Adolescent Medicine

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Section: Introductionmentioning

confidence: 99%

Management of asthma exacerbation in the emergency departments

Al-Shamrani

Alharbi‎

Bagais

et al. 2019

International Journal of Pediatrics and Adolescent Medicine

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“…Salbutamol is a useful medication that can be used in children of all ages. Inhaled via is the traditional route of administration [ 18 ]. S albutamol given continuously via nebulizer was not associated with a better outcome with respect to frequent intermittent administration, in a systematic review, dating back to 2003 and including only one pediatric study [ 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics

2018

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BackgroundAcute asthma attack is a frequent condition in children. It is one of the most common reasons for emergency department (ED) visit and hospitalization. Appropriate care is fundamental, considering both the high prevalence of asthma in children, and its life-threatening risks.Italian Society of Pediatrics recently issued a guideline on the management of acute asthma attack in children over age 2, in ambulatory and emergency department settings.MethodsThe Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology was adopted. A literature search was performed using the Cochrane Library and Medline/PubMed databases, retrieving studies in English or Italian and including children over age 2 year.ResultsInhaled ß2 agonists are the first line drugs for acute asthma attack in children. Ipratropium bromide should be added in moderate/severe attacks. Early use of systemic steroids is associated with reduced risk of ED visits and hospitalization. High doses of inhaled steroids should not replace systemic steroids. Aminophylline use should be avoided in mild/moderate attacks. Weak evidence supports its use in life-threatening attacks. Epinephrine should not be used in the treatment of acute asthma for its lower cost / benefit ratio, compared to β2 agonists. Intravenous magnesium solphate could be used in children with severe attacks and/or forced expiratory volume1 (FEV1) lower than 60% predicted, unresponsive to initial inhaled therapy. Heliox could be administered in life-threatening attacks. Leukotriene receptor antagonists are not recommended.ConclusionsThis Guideline is expected to be a useful resource in managing acute asthma attacks in children over age 2.

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“…Treatment of acute asthma consists of repeated doses of nebulized β 2 -agonists, systemic steroids and aminophylline in unresponsive cases. The administration of salbutamol during the emergency treatment of acute severe asthma was shown to be associated with a significant decrease in serum magnesium, potassium and phosphate levels [12].…”

Section: Discussionmentioning

confidence: 98%

Metabolic myocardial disorders in children with bronchial asthma

Herasymova

Protsiuk

et al. 2018

Patologìâ

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Objective. To study specific features of potassium metabolism and myocardial damage markers in the children with bronchial asthma, depending on the level of BA control. Materials and methods. Comprehensive examination was carried out in 189 children with persistent BA aged 6-17 years: group 1 consisted of 124 with uncontrolled course of the disease, group 2-30 patients with partially controlled BA and 35 patients with controlled BA. The comparison group consisted of 30 patients with controlled asthma without changes from the cardiovascular system. The unified flame photometry method with fluid analyzer FFA-1 was used to determine the erythrocyte potassium level. Total creatine phosphokinase level was estimated by UV-test. Creatine phosphokinase-MB level was determined by M-subunit immunoinhibition. Total lactic dehydrogenase-1 level was calculated by modified colorimetric method using an assay kit for colorimetric determination of total LDH. Serum LDH1 level was estimated by UV-method with the kit for determination of isoenzyme LDH1 activity. Results. In the children with UC BA serum K + and erythrocyte K + level was significantly lower compared to the children with PC BA, C BA, C BA with no changes in CVS and the control group. Total CPK and CPK-MB isoenzyme level in the children with UC BA, was significantly higher compared to those with PC BA, C BA, C BA without CVS changes and the control group. In the children with PC BA, total serum CPK level was also significantly higher compared to C BA (P = 0.007), C BA without CVS (P = 0.0002) changes and the control group (P = 0.001). Conclusion. Thus, the study demonstrated significant decrease of potassium level in blood serum and erythrocytes, twofold increase of total creatine phosphokinase and lactic dehydrogenase-1 isoenzyme levels, threefold increase in creatine phosphokinase-MB isoenzyme level, and one and a half time increase of total lactic dehydrogenase in the children with uncontrolled course of bronchial asthma.

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Salbutamol in paediatrics: pharmacology, prescribing and controversies

Cited by 14 publications

References 18 publications

Management of asthma exacerbation in the emergency departments

Management of asthma exacerbation in the emergency departments

Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics

Metabolic myocardial disorders in children with bronchial asthma

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