Salicylate‐induced hepatic injury

Barone, Richard; Chase, Peter

doi:10.1002/art.1780190529

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…From class I, we chose chlorpheniramine, which has DILI severity 0 (no documented liver toxicity). From class II, we chose aspirin (DILI severity 0 but has some potential for liver damage, such as elevated ALT upon prolonged high-dose usage and signs of hepatic injury (Athreya et al, 1973;Barone et al, 1976;Goldenberg, 1974;Koppes and Arnett, 1974;Rich and Johnson, 1973; No authors listed, 1973)), chlorpromazine (DILI severity 2, "adverse reactions" label), clotrimazole (DILI severity 3 and "adverse reactions" label), and ibuprofen (DILI severity 3 and "warnings and precautions" label). From class III, we chose atorvastatin (DILI severity 5 and "warnings and precautions" label), cyclosporin A (DILI severity 7 and "warnings and precautions" label), and amiodarone (DILI severity 8 and "box warning" label).…”

Section: Selection Of Drugs and Their Initial Analysismentioning

confidence: 99%

Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance

et al. 2021

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Pluripotent stem cells (PSCs) possess unique characteristics that distinguish them from other cell types. Human embryonic stem (ES) cells are recently gaining attention as a powerful tool for human toxicity assessment without the use of experimental animals, and an embryonic stem cell test (EST) was introduced for this purpose. However, human PSCs have not been thoroughly investigated in terms of drug resistance or compared with other cell types or cell states, such as naïve state, to date. Aiming to close this gap in research knowledge, we assessed and compared several human PSC lines for their resistance to drug exposure. Firstly, we report that RIKEN-2A human induced pluripotent stem (iPS) cells possessed approximately the same sensitivity to selected drugs as KhES-3 human ES cells. Secondly, both ES and iPS cells were several times less resistant to drug exposure than other non-pluripotent cell types. Finally, we showed that iPS cells subjected to naïve-state induction procedures exhibited a sharp increase in drug sensitivity. Upon passage of these naïve-like cells in non-naïve PSC culture medium, their sensitivity to drug exposure decreased. We thus revealed differences in sensitivity to drug exposure among different types or states of PSCs and, importantly, indicated that naïve-state induction could increase this sensitivity.

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Section: Selection Of Drugs and Their Initial Analysismentioning

confidence: 99%

Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance

et al. 2021

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show abstract

“…From class I, we chose chlorpheniramine, which has DILI severity 0 (no documented liver toxicity). From class II, we chose aspirin (DILI severity 0 but has some potential for liver damage, such as elevated ALT upon prolonged high-dose usage and signs of hepatic injury (Athreya et al, 1973;Barone et al, 1976;Goldenberg, 1974;Koppes and Arnett, 1974;Rich and Johnson, 1973;), chlorpromazine (DILI severity 2, "adverse reactions" label), clotrimazole (DILI severity 3 and "adverse reactions" label), and ibuprofen (DILI severity 3 and "warnings and precautions" label). From class III, we chose atorvastatin (DILI severity 5 and "warnings and precautions" label), cyclosporin A (DILI severity 7 and "warnings and precautions" label), and amiodarone (DILI severity 8 and "box warning" label).…”

Section: Selection Of Drugs and Their Initial Analysismentioning

confidence: 99%

Human ES and iPS Cells Display Less Drug Resistance Than Differentiated Cells, and Naïve-State Induction Further Decreases Drug Resistance

Panina

Yamane

Kobayashi

et al. 2020

Preprint

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Pluripotent stem cells (PSCs) possess unique characteristics that distinguish them from other cell types. Among them, human embryonic stem (ES) cells are gaining attention as a powerful tool for human toxicity assessment without the use of experimental animals, and the embryonic stem cell test (EST) was introduced for this purpose. However, some human PSCs, particularly induced pluripotent stem (iPS) cells, have not been thoroughly investigated and compared with other cell types or cell states in terms of chemical sensitivity. Aiming to close this gap, we assessed and compared several human PSC lines for their reaction to chemical exposure. We report that iPS cells are more sensitive to chemical exposure than other cell types, including ES cells. Specifically, RIKEN-2A human iPS cells were 1.5 times on average more sensitive to chemical exposure than KhES-3 human ES cells, and both were several times more sensitive to chemical exposure than non-pluripotent cell types. In addition, we showed that iPS cells subjected to naïve-state induction procedures exhibited a sharp increase in chemical sensitivity. However, upon passage of these naïve-like cells in conventional PSC culture medium, their sensitivity to chemical exposure decreased. In conclusion, we revealed differences in sensitivity to chemical exposure among different types and states of PSCs and that naïve-state induction could increase this sensitivity.

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Adverse Effects of Drugs on the Liver

Jim¹,

Gee²

1992

Applied Therapeutics

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Salicylate‐induced hepatic injury

Cited by 8 publications

References 11 publications

Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance

Human ES and iPS cells display less drug resistance than differentiated cells, and naïve-state induction further decreases drug resistance

Human ES and iPS Cells Display Less Drug Resistance Than Differentiated Cells, and Naïve-State Induction Further Decreases Drug Resistance

Adverse Effects of Drugs on the Liver

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