1972
DOI: 10.1172/jci106905
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Salicylate-induced increases in free triiodothyronine in human serum

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Cited by 167 publications
(29 citation statements)
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“…This may support the earlier findings of decreased plasma PBI levels and increased T4 turnover (Musa et al 1968;Woeber 8c Ingbar 1964; Wolff 8c Austen 1958) or decreased serum Tg and T4 together with increased free dialyzable fractions of these hormones (Larsen 1972). The findings of a decreased 13,I uptake by thyroid after salicylate (Goldberg et al 1957;Austen et al 1958) were explained as being due to a thyromimetic effect of salicylate on the pituitary gland.…”
Section: Discussionsupporting
confidence: 81%
“…This may support the earlier findings of decreased plasma PBI levels and increased T4 turnover (Musa et al 1968;Woeber 8c Ingbar 1964; Wolff 8c Austen 1958) or decreased serum Tg and T4 together with increased free dialyzable fractions of these hormones (Larsen 1972). The findings of a decreased 13,I uptake by thyroid after salicylate (Goldberg et al 1957;Austen et al 1958) were explained as being due to a thyromimetic effect of salicylate on the pituitary gland.…”
Section: Discussionsupporting
confidence: 81%
“…Recently, several reports appeared on the action of diphenylhydantoin (Larsen et al 1970), heparin (Schwartz et al 1973), salicylate (Larsen 1972), barbiturates (Michajlovskij 8c Knopp 1973), univalent anions (Michajlovskip 8c Langer 1974) and other compounds (reviewed by Oppenheimer 1973) on various changes in the peripheral meta¬ bolism of thyroid hormones in vivo and thus numerous preceding studies in vitro by several investigators were confirmed. In these experiments and also in some unpublished studies, however, we failed to demonstrate any effect of heparin on T4 disappearance rate from plasma.…”
Section: Discussionmentioning
confidence: 95%
“…Thus, the free T4 concentration cannot be calculated. It is likely, however, that the serum free T4 concentration in these rats is increased because Larsen has reported that salicylate, when added to human serum at a concentration of 30 mg/dl, doubles the free T4 concentration as measured by an ultrafiltration technique (25). Serum TSH concentrations I and 2 h after administration of EMD 21388.…”
Section: Resultsmentioning
confidence: 97%