Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach

Xing, Wenmin; Gao, Wenyan; Su, Huili; Wang, Sanying; Zhang, Jing; Mao, Genxiang; Yan, Jing

doi:10.1016/j.etap.2018.01.001

Cited by 4 publications

(3 citation statements)

References 64 publications

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“…eEF1Bβ was markedly decreased in senescent human fetal lung diploid fibroblasts cells, while treatment of these cells with a putative anti-aging agent caused an opposite effect (Xing et al, 2018). Similar influence of senescence on eEF1Bα (Byun et al, 2009) and eEF1Bβ (Takano et al, 2016), as well as on eEF1A1 (Byun et al, 2009) apparently reflects the global inhibition of protein synthesis during aging which supposedly occurs due to suppression of the whole eEF1B complex.…”

Section: Eef1bβmentioning

confidence: 87%

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

Negrutskii

2020

Front. Mol. Biosci.

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The human translation machinery includes three types of supramolecular complexes involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors eEF1B and multienzyme aminoacyl-tRNA synthetase complex. Of the above, eEF1B is the least investigated assembly. Recently, a number of studies provided some insights into the structure of different eEF1B subunits and changes in their expression in cancer and other diseases. There is increasing agreement that possible disease-related functions of eEF1B are not necessarily related to its role in translation. This mini-review focuses on structural and functional features of the eEF1B complex while paying special attention to possible non-canonical functions of its subunits in cancer cells.

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Section: Eef1bβmentioning

confidence: 87%

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

Negrutskii

2020

Front. Mol. Biosci.

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“…Ten TF genes regulated EEF1D, RPL31, and RPS14. As a translation elongation factor, EEF1D may control a range of cellular activities, including cell proliferation and growth, and also participates in anti-aging signal pathways [47]. According to research, EEF1D can interact with ribonucleoprotein (RNP) to inhibit the virus's RNP component from accessing the nucleus, indicating that EEF1D plays a function in viral infection [48].…”

Section: Discussionmentioning

confidence: 99%

A Bioinformatics and Systems Biology Approach to Establish the Pathogenetic Relationship between Long COVID and Post Traumatic Stress Disorder (PTSD)

Lu¹,

Cao²,

Wei³

2023

International Journal of Mental Health Promotion

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The COVID-19 pandemic, caused by the SARS coronavirus 2 (SARS-CoV-2), is a worldwide disaster. Despite the fact that many people recover from COVID-19 infection, they are likely to suffer chronic symptoms akin to Post-Traumatic Stress Disorder (PTSD) following discharge. Long COVID refers to symptoms that remain for months after infection and can result in significant cost burden and healthcare issues. The processes behind Long COVID and PTSD, however, remain unknown. We gathered the genes linked to Long COVID and PTSD from databases using constrained screening circumstances and clinical sample datasets with limited filters. Taking the intersection resulted in the discovery of the shared genes for Long COVID and PTSD. On the basis of common genes, we performed advanced bioinformatics analyses such as gene ontology and pathway enrichment analyses, protein-protein interaction (PPI) analysis, transcription factor (TF)-gene interaction network analysis, miRNA-gene interaction network analysis, and candidate drug analysis prediction. Through enrichment analysis, we discovered nine shared genes between Long COVID and PTSD and obtained thorough information on their biological activities and signaling networks. The PPI network collected ten hub proteins (RPL7, MRPL13, RPS14, RPS29, RPS9, RSL24D1, RPL31, RPS27L, EEF1D, MRPL15). Network Analyst demonstrated the TF-gene and TF-miRNA networks. Finally, ten possible chemical substances were anticipated. This research identified shared gene interaction networks between PTSD and Long COVID and suggested novel therapeutics for use in clinical settings. Our research identifies a possible molecular link between Long COVID and PTSD. Prior to future clinical application, more experimental and clinical research is needed to investigate improved mechanistic understanding.

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“…As a translation elongation factor, EEF1D can regulate a variety of cellular processes, including cell proliferation and growth, and also participates in anti-aging signal pathways (8). Relevant studies have shown that when EEF1D is overexpressed, it can play a role as a proto-oncogene.…”

Section: Introductionmentioning

confidence: 99%

The role of EEF1D in disease pathogenesis: a narrative review

Xu¹,

Yu²,

Peng³

et al. 2021

Ann Transl Med

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Objective: The purpose of this paper was to investigate the role and mechanism of EEF1D in various diseases, especially in tumorigenesis and development, and explore the possibility of EEF1D as a biological target.Background: EEF1D is a part of the EEF1 protein complex, which can produce four protein isoforms, of which three short isoforms are used as translation elongation factors. The three short isoforms play a role in anti-aging, regulating the cell cycle, and promoting the occurrence and development of malignant tumors, and the only long-form isoform plays a role in the development of the nervous system.Methods: We searched the PubMed and Web of Science databases for literature up to January 2021 using relevant keywords, including "EEF1D", "eukaryotic translation elongation factor 1 delta", "translation elongation factor", "translation elongation factor and cancer", and "translation elongation factor and nervous system disease". We then created an overview of the literature and summarized the results of the paper.Conclusions: Through the review of relevant articles, we found that EEF1D is obviously overexpressed in a variety of tumors, and can regulate the proliferation of tumor cells and tumor growth, as well as play a role in tumor invasion. EEF1D is likely to become a new biological target for tumor therapy and diagnosis.

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Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach

Cited by 4 publications

References 64 publications

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

A Bioinformatics and Systems Biology Approach to Establish the Pathogenetic Relationship between Long COVID and Post Traumatic Stress Disorder (PTSD)

The role of EEF1D in disease pathogenesis: a narrative review

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