Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune response of oral epithelial cells on titanium surfaces

Huang, Baoxin; Liu, Chun; Yang, Jieting; Xiang, Enmao; Ivanovski, Sašo; Han, Pingping

doi:10.1007/s00784-023-05454-9

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Bacterial EVs play a significant role in biofilm formation, an essential survival strategy for bacteria. EVs contribute to biofilm formation and maintenance by mediating adhesive interactions, facilitating nutrient delivery to cells within the biofilm matrix, and enabling the long-range transport of molecules involved in virulence and antibiotic resistance [ 46 , 47 , 48 ].…”

Section: Evs In Plant–microbe Interactions: Biogenesis and Functional...mentioning

confidence: 99%

Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant–Microbe Interactions

Pandey,

Blache,

Achouak

2024

Microorganisms

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Plant–microbe interactions play a crucial role in shaping plant health and survival. In recent years, the role of extracellular vesicles (EVs) in mediating intercellular communication between plants and microbes has emerged as an intriguing area of research. EVs serve as important carriers of bioactive molecules and genetic information, facilitating communication between cells and even between different organisms. Pathogenic bacteria leverage extracellular vesicles (EVs) to amplify their virulence, exploiting their cargo rich in toxins and virulence factors. Conversely, beneficial microbes initiate EV secretion to stimulate plant immune responses and nurture symbiotic relationships. The transfer of EV-packed small RNAs (sRNAs) has been demonstrated to facilitate the modulation of immune responses. Furthermore, harnessing the potential of EVs holds promise for the development of innovative diagnostic tools and sustainable crop protection strategies. This review highlights the biogenesis and functions of EVs in bacteria and their importance in plant defense, and paves the way for future research in this exciting field.

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Section: Evs In Plant–microbe Interactions: Biogenesis and Functional...mentioning

confidence: 99%

Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant–Microbe Interactions

Pandey,

Blache,

Achouak

2024

Microorganisms

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Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation

Xiang,

Vaquette,

Liu

et al. 2024

Adv Funct Materials

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Zinc (Zn) is gaining increased recognition as a biodegradable metal in biomedical applications but clinical translation is limited due to its poor biocompatibility. This study addresses these issues through an innovative biomimetic strategy, introducing an efficient surface nanoengineering approach that creates nano‐geometric features and chemical compositions by modulating the exposure time to a biological medium – Dulbecco's Modified Eagle Medium(DMEM). These nanoengineered Zn implants exhibited tunable degradation rates. The nanostructures enhanced human osteoblast attachment, proliferation, and differentiation following direct contact, and improved macrophage function by promoting pseudopod formation and transitioning from a pro‐inflammatory M1 to a pro‐reparative M2 phenotype. In vivo studies show that the surface‐engineered implants effectively promoted tissue integration via M2 macrophage polarization, resulting in a favorable immunomodulatory environment, and increased collagen deposition. Proteomic analyses show that the tissues in the vicinity of the surface‐engineered Zn implants are enriched with proteins related to key wound healing biological mechanisms such as cell adhesion, cytoskeletal structural arrangement, and immune response. This study highlights the improved biocompatibility and anti‐inflammatory effects of surface‐engineered Zn, with important implications for the clinical translation of biodegradable Zn‐based orthopedic implants.

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Unveiling clinical applications of bacterial extracellular vesicles as natural nanomaterials in disease diagnosis and therapeutics

Liu,

Yazdani,

Moran

et al. 2024

Acta Biomaterialia

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Saliva biofilm-derived outer membrane vesicles regulate biofilm formation and immune response of oral epithelial cells on titanium surfaces

Cited by 4 publications

References 49 publications

Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant–Microbe Interactions

Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant–Microbe Interactions

Biomimetic Surface Nanoengineering of Biodegradable Zn‐Based Orthopedic Implants for Enhanced Biocompatibility and Immunomodulation

Unveiling clinical applications of bacterial extracellular vesicles as natural nanomaterials in disease diagnosis and therapeutics

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