Salivary Alterations in Diabetes Mellitus

Abstract

Separately collected parotid and submaxillary salivary samples from 20 diabetic and 20 matched control subjects were analyzed for flow rate, electrolyte content and immunoglobulin (IgA, IgG and IgM) levels. Flow rates did not vary significantly between the two groups of subjects; calcium ion content, however, was higher in the diabetic subjects for both salivary glands. The presence of salivary IgI in 6 of 10 patients was also a significant finding. Any attempt to draw a conclusion between the severity of periodontal disease and Diabetes Mellitus from the above findings is still speculative but does indicate further areas of research.

Dental caries and adolescents with type 1 diabetes

“…The age of the patient at the onset of DM was correlated to the caries condition DM patients are known to exhibit hyposalivation with a decrease in the saliva secretion rate, 6,26,27 this changing as a function of the metabolic care. Lower saliva secretion and pH also tends to promote the growth of acidogenic microorganisms such as lactobacilli, mutans streptococci and Candida, as a consequence of diminished mechanical cleaning, increased dental plaque, 28 a long-lasting acidic milieu, and the faulty self-cleansing of the teeth, which all favour caries development.…”

Estimation and Comparison of Serum and Salivary IgA Levels in Controlled, Uncontrolled Diabetics and Normal Individuals

“…Marder MZ, Abelson DC and Mandel ID (1975) reported no statistical differences in salivary A levels. 14 Ben-Arych H and Cohen M (1988) reported diminuation of whole salivary flow, but no reduction in salivary IgA level in insulin-dependent diabetics. 15 Claman et al and Gave (1972) have reported the IgA content of normal saliva to be 2 to 5 mg% accounting for 1 to 3% of total salivary proteins.…”

“…16 Marder MZ et al (1982) found that the levels of secretory IgA were generally within their normal range in diabetes mellitus. 17 Brandtzaeg (1972) and found that there was significantly elevated IgA level in whole saliva of diabetic patients. 18,19 …”

Estudo da freqüência de cárie e fatores associados no diabetes mellitus tipo 1

“…Estudos abordando a freqüência da cárie dental em populações diabéticas são escassos; na maioria das vezes, são estudos clínicos e testam possíveis associações com o controle metabólico (4)(5)(6)(7)(8). Não está esclarecido se a instabilidade glicêmica no DM tipo 1, possivelmente alterando a concentração de glicose salivar e a flora bacteriana, poderia predispor ao aparecimento de cárie (8)(9)(10)(11)(12)(13)(14)(15).…”