Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

Jong, Miranda de; Cranendonk, Anneke; Weissenbruch, Mirjam M. van

doi:10.1038/pr.2015.128

Cited by 5 publications

(9 citation statements)

References 25 publications

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“…All blood samples were taken early in the afternoon after a fasting period of at least 3 h. Samples were stored at −80°C and were all analyzed at the same time. Study population and data collection also have been previously described [3, 4, 16, 17].…”

Section: Methodsmentioning

confidence: 99%

“…The third aim was to investigate the relationship between F/E ratio and components of the metabolic syndrome at 2-year (corrected) age in the total group of children (VLBW and term AGA). The cortisol levels of the VLBW children were presented earlier, in relation to blood pressure [4]. The present study focuses on the F/E ratio and the comparison to term-born AGA children.…”

Section: Introductionmentioning

confidence: 92%

“…The VLBW children were part of the Neonatal Insulin Replacement Therapy in Europe (NIRTURE) trial [8]. We showed earlier that at 2-year corrected age, insulin-treated children had higher serum cortisol levels than children in the standard care group [4]. In the present study we also evaluate the effect of early insulin therapy on serum cortisone and F/E ratio.…”

Section: Introductionmentioning

confidence: 99%

“…Programming of the hypothalamic-pituitary-adrenal (HPA) axis plays an important role in the association between intra-uterine growth restriction (IUGR) and/or preterm birth and higher blood pressure in later life. Very-low-birthweight (VLBW) infants have a high prevalence of raised blood pressure already in early childhood [1-3], and we earlier showed that at the corrected age of 2 years, cortisol levels are positively correlated to blood pressure in VLBW boys [4].…”

Section: Introductionmentioning

confidence: 99%

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Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants

et al. 2020

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Introduction: Besides programming of the hypothalamic-pituitary-adrenal (HPA) axis, changes in the activity of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) could contribute to the later metabolic and cardiovascular consequences of preterm birth. Objective: We compared serum cortisol, cortisone, and cortisol/cortisone ratio in early childhood in very-low-birthweight (VLBW) infants and term appropriate for gestational age (AGA) born infants. Methods: We included 41 VLBW infants, participating in the randomized controlled Neonatal Insulin Replacement Therapy in Europe trial, and 64 term AGA-born infants. Cortisol and cortisone were measured in blood samples taken at 6 months and 2 years corrected age (VLBW children) and at 3 months and 1 and 2 years (term children). At 2 years of (corrected) age (HDL) cholesterol, triglycerides, glucose, and insulin were also measured. Results: During the first 2 years of life, cortisol/cortisone ratio is higher in VLBW children compared to term children. In the total group of children, cortisol/cortisone ratio is positively related to triglycerides at 2 years of (corrected) age. In VLBW children, over the first 2 years of life both cortisol and cortisone are higher in the early-insulin group compared to the standard care group. Conclusions: In VLBW infants, lower 11β-HSD2 activity probably contributes to the long-term metabolic and cardiovascular risks. In VLBW infants, early insulin treatment could affect programming of the HPA axis, resulting in higher cortisol and cortisone levels during early childhood.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants

et al. 2020

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“…These neonates obviously contribute to neonatal morbidity and mortality [2]. As reported, these neonates also have more developmental difficulties in later life, such as behavioral and emotional problems, cardiovascular disease and metabolic disease [3,4]. The most important and direct developmental factors in the newborns are their nutritional and metabolic profiles, which can be reflected by AA and AC [5].…”

Section: Introductionmentioning

confidence: 98%

Performance of LC/MS/MS in Analyzing Multiple Amino Acids and Acylcarnitines in Dried Blood Spot of Very Low Birth Weight, Low Birth Weight, and Normal Weight Neonates

Yu¹,

Han²,

Duan³

et al. 2018

Clin. Lab.

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Background: Amino acid (AA) and acylcarnitine (AC) are important biomarkers of protein and fatty acid metabolism. Examining their levels in newborns may reveal multiple inherited metabolic diseases. However, they have rarely been assessed in very low birth weight (VLBW) neonates, low birth weight (LBW) neonates and rarely been compared with normal weight (NW) neonates. The aim of the study was to identify the AA and AC profiles in dried blood spot (DBS) specimens of LBW and VLBW neonates, then compare with NW neonates, and make a contribution to the determination of cutoff values of VLBW and LBW neonates. Methods: Liquid Chromatography tandem mass spectrometry (LC/MS/MS) is an excellent tool for quantitatively detecting AA and AC profiles. This article verified the precision, accuracy, and linearity of the LC/MS/MS method in AA and AC detection, then analyzed AA and AC profiles in DBS of VLBW, LBW and NW neonates, and compared the difference of AA and AC in the three groups. Results: The results showed that the LC/MS/MS method had wide linear range, satisfied precision and reproducibility in detecting AA and AC in DBS specimens; most AA and AC concentrations significantly correlated with birth weight in DBS samples (p < 0.05). Conclusions:The results suggested that VLBW and LBW neonates have different metabolic or nutritional status with NW neonates and different AA and AC cutoffs should be defined for them to reduce the risk of false-positive cases.

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Child and Maternal Factors That Influence Child Blood Pressure in Preschool Children: An Exploratory Study

Rice

Turner-Henson

Park

et al. 2016

Applied Nursing Research

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Salivary and serum cortisol and relation to blood pressure in infancy and early childhood in very-low-birth-weight infants

Cited by 5 publications

References 25 publications

Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants

Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants

Performance of LC/MS/MS in Analyzing Multiple Amino Acids and Acylcarnitines in Dried Blood Spot of Very Low Birth Weight, Low Birth Weight, and Normal Weight Neonates

Child and Maternal Factors That Influence Child Blood Pressure in Preschool Children: An Exploratory Study

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