Salivary anti-coxsackievirus-B4 neutralizing activity and pattern of immune parameters in patients with type 1 diabetes: a pilot study

Nekoua, Magloire Pandoua; Yessoufou, Akadiri; Alidjinou, Enagnon Kazali; Badia-Boungou, Francis; Moutaïrou, Kabirou; Sané, Famara; Hober, Didier

doi:10.1007/s00592-018-1158-3

Cited by 7 publications

(8 citation statements)

References 39 publications

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“…The presence of enteroviruses in the gut can result in specific IgA antibodies in both the intestinal mucosa and saliva, as all inducer and effector sites of the mucosa-associated lymphoid tissue are functionally interconnected 56 . For example, in studies from several countries (France, Republic of the Congo, Lebanon and Benin), high titres of neutralizing IgA1 anti-CVB4 antibodies were detected in the saliva more often in patients with T1DM than in control individuals 57 , 58 . Interestingly, this salivary anti-CVB4 activity was maintained throughout a 4-year follow-up period in patients with T1DM but not in control individuals 57 .…”

Section: Enterovirus Persistence In T1dmmentioning

confidence: 99%

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

2022

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Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and type 1 diabetes mellitus (T1DM). Although enteroviruses are primarily involved in acute and lytic infections in vitro and in vivo, they can also establish a persistent infection. Prospective epidemiological studies have strongly associated the persistence of enteroviruses, especially coxsackievirus B (CVB), with the appearance of islet autoantibodies and an increased risk of T1DM. CVB can persist in pancreatic ductal and β-cells, which leads to structural or functional alterations of these cells, and to a chronic inflammatory response that promotes recruitment and activation of pre-existing autoreactive T cells and β-cell autoimmune destruction. CVB persistence in other sites, such as the intestine, blood cells and thymus, has been described; these sites could serve as a reservoir for infection or reinfection of the pancreas, and this persistence could have a role in the disturbance of tolerance to β-cells. This Review addresses the involvement of persistent enterovirus infection in triggering islet autoimmunity and T1DM, as well as current strategies to control enterovirus infections for preventing or reducing the risk of T1DM onset.

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Section: Enterovirus Persistence In T1dmmentioning

confidence: 99%

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

2022

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“…The study process is shown in Figure 1. Among 1501 potentially relevant studies, 38 met the inclusion criteria (10,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58). The dataset included 5921 subjects (2841 T1D patients and 2841 controls).…”

Section: Characteristics Of the Studies Included In The Meta-analysismentioning

confidence: 99%

“…A meta-analysis identified the correlation between enterovirus infection and T1D in 2011 (17). Although several original studies have been reported from 2012 to 2020 (10,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), no updated meta-analysis has been performed to explore and refine the correlation. The conclusions of the original studies are conflicting, and thus, a meta-analysis including the latest studies is still needed to evaluate the association between enterovirus infection and T1D.…”

Section: Introductionmentioning

confidence: 99%

Association Between Enterovirus Infection and Type 1 Diabetes Risk: A Meta-Analysis of 38 Case-Control Studies

Wang

Chen

et al. 2021

Front. Endocrinol.

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ObjectiveThe association between enterovirus infection and type 1 diabetes (T1D) is controversial, and this meta-analysis aimed to explore the correlation.MethodsPubMed, Embase, Web of Science, and Cochrane Database were searched from inception to April 2020. Studies were included if they could provide sufficient information to calculate odds ratios and 95% confidence intervals. All analyses were performed using STATA 15.1.ResultsThirty-eight studies, encompassing 5921 subjects (2841 T1D patients and 3080 controls), were included. The pooled analysis showed that enterovirus infection was associated with T1D (P < 0.001). Enterovirus infection was correlated with T1D in the European (P < 0.001), African (P = 0.002), Asian (P = 0.001), Australian (P = 0.011), and Latin American (P = 0.002) populations, but no conclusion could be reached for North America. The association between enterovirus infection and T1D was detected in blood and tissue samples (both P < 0.001); no association was found in stool samples.ConclusionOur findings suggest that enterovirus infection is associated with T1D.

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“…Taken together, these findings indicate that the activity of salivary anti-Coxsackievirus B4 in T1DM patients is associated with immune system dysregulation. Thus, the anti-Coxsackievirus B4 activity in the saliva can be used as a non-invasive marker to examine the viral pathogenesis of T1DM, especially in high-risk populations [ 41 ].…”

Section: Africamentioning

confidence: 99%

Enteroviruses and Type 1 Diabetes Mellitus: An Overlooked Relationship in Some Regions

Sané¹,

Lazrek²,

Nekoua

et al. 2020

Microorganisms

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Enteroviruses (EVs) infect millions of people annually. EV infections can be asymptomatic or symptomatic with conditions ranging from mild illnesses to serious diseases such as dilated cardiomyopathy. A causal relationship between EV infections and type 1 diabetes mellitus (T1DM) has been heavily debated, with some studies suggesting that this relationship is not yet conclusive and requires additional evidence, whereas others strongly argue for this correlation. While this relationship is well investigated in some developed countries like the USA and Finland, it is understudied or neglected in other countries like Russia for many reasons such as the low incidence of T1DM. Although the Middle East and North Africa (MENA) are highly affected by T1DM, the role of EVs in the disease in MENA has not been investigated extensively. Therefore, we aimed to address the relationship between T1DM and EVs in MENA and other regions globally.

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Salivary anti-coxsackievirus-B4 neutralizing activity and pattern of immune parameters in patients with type 1 diabetes: a pilot study

Abstract: The association between saliva anti-CV-B4 activity and disturbance of immune system in T1D patients deserves further investigation.

Cited by 7 publications

References 39 publications

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

Association Between Enterovirus Infection and Type 1 Diabetes Risk: A Meta-Analysis of 38 Case-Control Studies

Enteroviruses and Type 1 Diabetes Mellitus: An Overlooked Relationship in Some Regions

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