Salivary bisphenol A levels and their association with composite resin restoration

Lee, Jung-Ha; Yi, Seung-Kyoo; Kim, Se-Yeon; Kim, Ji-Soo; Son, Sung-Ae; Jeong, Seung-Hwa

doi:10.1016/j.chemosphere.2016.12.123

Cited by 32 publications

(28 citation statements)

References 23 publications

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“…One week after treatment the concentration of BPA in saliva was only marginally higher than before treatment. This is in agreement with the results from other studies of BPA leakage from existing polymer‐based fillings . The time‐course of the salivary BPA concentration after treatment is in accordance with other studies and supports a plausible pattern, which suggests that the main exposure to BPA from polymer‐based dental filling materials is limited to a short period after placement .…”

Section: Discussionsupporting

confidence: 91%

“…has been questioned and the levels have not been confirmed by later studies. Other authors have evaluated the release of BPA in saliva after placement of Bis‐GMA‐based dental materials used as restoratives and in orthodontic treatment, bonding lingual retainers , or brackets . The salivary BPA levels reported in these studies are considerably lower than the levels reported in the present study.…”

Section: Discussioncontrasting

confidence: 67%

“…It has been shown that Bis‐DMA‐based materials, such as Delton LC fissure sealant (Ash/Dentsply, York, PA, USA), may release BPA as a result of hydrolysis at the ester bond , whereas Bis‐GMA‐based materials, which typically comprise restorative materials, do not undergo this form of biodegradation because its ether bond is resistant to hydrolysis . Several in‐vitro and some in‐vivo studies have focused on BPA leakage from dental polymer‐based filling materials and have attempted to quantify the amounts detected in different solutions or biological media . However, the amounts reported vary, probably because of differences in the materials examined and the methodological approaches .…”

mentioning

confidence: 99%

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Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Berge

Lygre

Lie

et al. 2019

European J Oral Sciences

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The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer‐based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer‐based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer‐based restorations. Following placement, the concentration of BPA decreased exponentially with time. One week after treatment the BPA level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the BPA concentration was detected after treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 67%

mentioning

confidence: 99%

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Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Berge

Lygre

Lie

et al. 2019

European J Oral Sciences

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“…Though these molecules used in dental sealants and possibly composites contain the BPA core, degradation studies have failed to detect the presence of BPA by-products from dental sealants [105]. The other degradation products can be toxic at the local level, but exposure to them is considered to be brief as they are quickly cleared by the saliva [106]. Several studies concluded that the cumulative exposure level to sealants and/or flowable composites was not associated with behavioral, psychosocial or neuropsychological alteration [107–109], and the American Dental Association has deemed sealants safe for use in children and adults ( ADA - FDA in dental sealants ).…”

Section: Toxicity and The Bpa Controversymentioning

confidence: 99%

Polymer-Based Direct Filling Materials

Pfeifer

2017

Dental Clinics of North America

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Synopsis After a brief review of current restorative materials and classifications, this article discusses the latest developments in polymer-based direct filling materials, with emphasis on products and studies available in the last 10 years. This will include the more recent bulk-fill composites and self-adhesive materials, for which clinical evidence of success, albeit somewhat limited, is already available. The article will also introduce the latest cutting edge research topics on new materials for composite restorations, and an outlook for the future of how those may help improve the service-life of dental composite restorations.

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“…Conversely, there are only a few studies aimed at determining some of these compounds in saliva by LC, including detection methods other than FD (e.g. diode array, electrochemical, mass spectrometry, ELISA; Berge et al, ; Lee et al, ; Silva et al, ). However, the main differences of these studies in comparison with the present one lie in the aspect that they considered only one compound (e.g., BPA or MEHP) or at maximum two compounds (i.e., TCS and 2CP) at the same time (Berge et al, ; Sakai, ; Silva et al, ; Silva & Nogueira, ).…”

Section: Resultsmentioning

confidence: 99%

Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method

Russo

Barbato

Mita³

2018

Biomedical Chromatography

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A quick and inexpensive validated method, based on sample treatment by liquidliquid microextraction followed by liquid chromatography (LC) coupled with ultraviolet tandem fluorescence detection is proposed for the determination of 15 multiclass pollutants both in serum and in saliva, as a simple and easy to draw matrix. The method was set up and validated according to European guidelines. The compounds of interest include some endocrine-disrupting chemicals (i.e. bisphenol A, bisphenol B, bisphenol E, bisphenol F, bisphenol AF, bisphenol A diglycidyl ether, bisphenol M, diethylhexyl phthalate, monoethylhexyl phthalate, triclosan and 4-nonylphenol), as well as other pollutants belonging to the class of volatile organic compounds (2chlorophenol, 1,2 dichlorobenzene, 1,2,4,5-tetrachlorobenzene). The limits of quantifications ranged from 2.28 × 10 −3 μg mL −1 (bisphenol A diglycidyl ether) to 6.29 μg mL −1 (diethylhexyl phthalate), while those of detection ranged from 0.068 × 10 −3 μg mL −1 (bisphenol A diglycidyl ether) to 1.031 μg mL −1 (diethylhexyl phthalate). To test method suitability, it was applied to real saliva and serum samples of healthy human volunteers and was found to meet the demands of the laboratories handling simple and relatively inexpensive equipment for screening oriented at rapid and reliable contamination assessment of a population.

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Salivary bisphenol A levels and their association with composite resin restoration

Cited by 32 publications

References 23 publications

Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Polymer-Based Direct Filling Materials

Simultaneous determination of fifteen multiclass organic pollutants in human saliva and serum by liquid chromatography–tandem ultraviolet/fluorescence detection: A validated method

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