Salivary Cortisol and Cold Pain Sensitivity in Female Twins

Godfrey, Kathryn; Strachan, Eric; Dansie, Elizabeth J.; Crofford, Leslie J.; Buchwald, Dedra; Goldberg, Jack; Poeschla, Brian; Succop, Annemarie; Noonan, Carolyn; Afari, Niloofar

doi:10.1007/s12160-013-9532-4

Cited by 18 publications

(22 citation statements)

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“…This study further documented in a sample of postpartum Latina women the expected relationship between greater CORT reactivity to the CPT stressor and increased pain tolerance, when analyzed in the sample as a whole, which is congruent with the expected HPA axis endogenous pain regulatory effect (Godfrey et al, 2014; Mechlin et al, 2005). To the extent that greater cortisol reactivity to the CPT would be expected to be associated with decreased sensitivity to painful stimuli, the pattern of blunted cortisol reactivity to the CPT seen in women with depression at all time points relative to their non-affected counterparts may have contributed to their general pattern of enhanced sensitivity to cold pressor pain (reflected in their nonsignificant pattern of lower pain threshold and tolerance times and higher pain intensity ratings).…”

Section: Discussionsupporting

confidence: 66%

“…While the CPT activates stress-responsive axes, including the HPA and sympathetic nervous system axes (Godfrey et al, 2014; Santa Ana et al, 2006; Schwabe, Haddad, & Schachinger, 2008), and is commonly used as a physical stressor in laboratory studies, it is also a potent noxious stimulus (Girdler et al, 2005; Gordon, Johnson, Nau, Mechlin, & Girdler, 2017; Light et al, 1999). Consistent with a stress-induced, endogenous pain regulatory mechanism (Choi, Chung, & Lee, 2012; Geva, Pruessner, & Defrin, 2014; Hannibal & Bishop, 2014; Paananen et al, 2015), studies in non-clinical samples generally find a positive correlation between cortisol levels and tolerance to noxious stimuli, including the CPT (Mechlin, Maixner, Light, Fisher, & Girdler, 2005; Sudhaus et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Consistent with a stress-induced, endogenous pain regulatory mechanism (Choi, Chung, & Lee, 2012; Geva, Pruessner, & Defrin, 2014; Hannibal & Bishop, 2014; Paananen et al, 2015), studies in non-clinical samples generally find a positive correlation between cortisol levels and tolerance to noxious stimuli, including the CPT (Mechlin, Maixner, Light, Fisher, & Girdler, 2005; Sudhaus et al, 2015). Additionally, reduced diurnal variation of cortisol, a reflection of HPA axis dysregulation, is correlated with increased pain sensitivity in response to the CPT (Godfrey et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

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Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

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Background Latinas are disproportionately affected by perinatal depression (PND) as well as by adverse life events (ALEs), an independent predictor of PND. Dysregulation of the hypothalamic-adrenal-pituitary (HPA) axis has been seen both in women with PND and with a history of ALEs in non-Latinas. Though some evidence suggests that HPA axis dysregulation may mediate the link between ALEs and PND, this has received little attention and there are no studies that have examined these pathways in Latinas. The primary aim of the present study was to explore, in a Latina sample, associations between ALEs, PND, and HPA axis stress reactivity to a physical stressor-the cold pressor test (CPT). The secondary aim was to explore whether HPA axis reactivity and PND were associated with pain sensitivity to the CPT. Methods Thirty-four Latinas were enrolled in their third trimester of pregnancy and interviewed at 4 and 8 weeks postpartum. Depression status was determined using the Edinburgh Postnatal Depression Scale (≥ 10). At 8 weeks postpartum, 27 women underwent laboratory-induced pain testing using the cold pressor test (CPT). Plasma adrenocorticotropic hormone (ACTH) and cortisol (CORT) were sampled pre- and post-CPT to generate a stress reactivity score (post-pre). Pain sensitivity and ALEs were also assessed. Results At enrollment, 26% of women were depressed and 18% were depressed at 8 weeks postpartum. Forty-eight percent reported at least one childhood ALE. There was a significant and positive association between any childhood ALE and prenatal depression scores (p = 0.025). Infant-related ALEs were significantly associated with greater ACTH reactivity to the CPT (p = 0.030). Women with a history of any childhood ALE exhibited a blunted CORT response to the CPT (p = 0.045). Women with a history of PND at 4 weeks had greater ACTH stress reactivity to the CPT (p = 0.027). No significant effects of PND were seen for pain sensitivity measures in response to the CPT, though there was a positive and significant correlation between pain tolerance and CORT response to the CPT in the whole sample. Conclusions Given the associations between ALEs and PND and their individual effect on HPA axis stress reactivity, future studies on perinatal depression should include a larger sample of Latinas to test mediating effects of HPA axis reactivity on associations between ALEs and PND.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

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“…healthy control pairs). As reported previously (42, 43), in order to participate, both twins were required to be free from severe or chronic medical conditions that could potentially be the source of the unexplained pain (e.g. autoimmune disorders, cancer, etc.…”

Section: Methodsmentioning

confidence: 99%

Clinical and evoked pain, personality traits, and emotional states: Can familial confounding explain the associations?

Strachan

Poeschla

Dansie

et al. 2015

Journal of Psychosomatic Research

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Objectives Pain is a complex phenomenon influenced by context and person-specific factors. Affective dimensions of pain involve both enduring personality traits and fleeting emotional states. We examined how personality traits and emotional states are linked with clinical and evoked pain in a twin sample. Methods 99 female twin pairs were evaluated for clinical and evoked pain using the McGill Pain Questionnaire (MPQ) and dolorimetry, and completed the 120-item International Personality Item Pool (IPIP), the Positive and Negative Affect Scale (PANAS), and ratings of stress and mood. Using a co-twin control design we examined a) the relationship of personality traits and emotional states with clinical and evoked pain, and b) whether genetics and common environment (i.e. familial factors) may account for the associations. Results Neuroticism was associated with the sensory component of the MPQ; this relationship was not confounded by familial factors. None of the emotional state measures was associated with the MPQ. PANAS Negative Affect was associated with lower evoked pressure pain threshold and tolerance; these associations were confounded by familial factors. There were no associations between IPIP traits and evoked pain. Conclusions A relationship exists between neuroticism and clinical pain that is not confounded by familial factors. There is no similar relationship between negative emotional states and clinical pain. In contrast, the relationship between negative emotional states and evoked pain is strong while the relationship with enduring personality traits is weak. The relationship between negative emotional states and evoked pain appears to be non-causal and due to familial factors.

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“…Existe uma associação entre a sensibilidade à dor e os níveis endógenos de cortisol salivar, pois indivíduos com variações nas concentrações de cortisol ao longo do dia apresentam maior sensibilidade à dor (GODFREY et al, 2014).…”

Section: Sensibilidade à Dor (Limiar De Dor à Pressão)unclassified

Efetividade da laserterapia de baixa intensidade em mulheres com DTM dolorosa em função da ansiedade, cortisol salivar e ciclo menstrual: ensaio clínico randomizado controlado duplo-cego

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Salivary Cortisol and Cold Pain Sensitivity in Female Twins

Cited by 18 publications

References 50 publications

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Clinical and evoked pain, personality traits, and emotional states: Can familial confounding explain the associations?

Efetividade da laserterapia de baixa intensidade em mulheres com DTM dolorosa em função da ansiedade, cortisol salivar e ciclo menstrual: ensaio clínico randomizado controlado duplo-cego

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