Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder

Bicanic, Iva A. E.; Postma, Riemke; Sinnema, Gerben; Roos, Carlijn de; Olff, Miranda; Wesel, Floryt van; Putte, Elise M. van de

doi:10.1016/j.psyneuen.2012.06.015

Cited by 56 publications

(33 citation statements)

References 36 publications

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“…It is possible that childhood adversity increases CRH reactivity, which subsequently affects sleep quality, but the research concerning the association between ACEs and cortisol is inconclusive. Multiple investigators have shown that a history of childhood abuse or maltreatment is associated with increased cortisol reactivity, supporting the proposed hypothesis [63-67], while others have shown ACEs to be associated with diminished cortisol reactivity [68-70]. Thus, it is unclear whether or not elevated CRH explains the association between ACEs and poorer sleep.…”

Section: Discussionmentioning

confidence: 94%

Adverse childhood experiences are associated with adult sleep disorders: a systematic review

et al. 2015

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Adverse childhood experiences (ACEs) represent substantial threats to public health and affect about 58% of youth in the US. In addition to their acute effects such as injury and physical trauma, ACEs are associated with an increased risk of several negative health outcomes throughout the life course. Emerging evidence suggests sleep disorders may be one such outcome, but existing studies have not been systematically reviewed and summarized. We conducted a systematic review to summarize the evidence concerning the relationship between ACEs and sleep disorders and disturbances, with a focus on adult women. Original publications were identified through searches of the electronic databases MEDLINE, Embase, and Web of Science using key words “childhood,” “adversity,” “abuse,” and “sleep” as well as searches of the reference lists of eligible studies. Studies evaluating ACEs that occurred before 18 years of age and sleep outcomes that were assessed at 18 years or older were adjudicated and included. A total of 30 publications were identified. Of the 30 studies, 28 were retrospective analyses and there was vast heterogeneity in types of ACEs and sleep outcomes measured. The majority of retrospective studies (N=25 of 28) documented statistically significant associations between sleep disorders including sleep apnea, narcolepsy, nightmare distress, sleep paralysis, and psychiatric sleep disorders with a history of childhood adversity. In many studies, the strengths of associations increased with the number and severity of adverse experiences. These associations were corroborated by the two prospective studies published to date. Notably, investigators have documented statistically significant associations between family conflict at 7-15 years of age and insomnia at 18 years of age (OR = 1.4; 95% CI = 1.2-1.7) and between childhood sexual abuse and sleep disturbances 10 years later in adult women (β = 0.24, p < 0.05). There is a growing scientific body of knowledge suggesting an association between ACEs and multiple sleep disorders in adulthood. Available evidence indicates the need to develop treatment strategies such as trauma-informed care for survivors of abuse who are suffering from sleep disorders and disturbances. Further, longitudinal studies among diverse populations are needed to improve overall understanding of this association and to investigate potential gender and racial/ethnic disparities in the strength of the association.

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Section: Discussionmentioning

confidence: 94%

Adverse childhood experiences are associated with adult sleep disorders: a systematic review

et al. 2015

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“…While PTSD is mainly characterized by blunted cortisol responses (Meewisse et al 2007;Bicanic et al 2013); depressed patients (particularly those with severe and/or melancholic depression) show HPA-axis hyperactivity thought to result from impaired HPA-axis feedback through the glucocorticoid receptor (Pariante et al 2004;Stetler and Miller 2011;Lok et al 2012). The Bvicious^circle, potentially resulting from the bidirectional relationship between fatty acid metabolism and the HPA-axis (described in Bidirectional relation with hypothalamic-pituitary-adrenal (HPA)-axis) fits with our observations of associations between fatty acid metabolism and cortisol in depression.…”

Section: Associations With Other Pathophysiological Mechanismsmentioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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“…However, evidence is limited and long-term risks -including possible carcinogenic effects (Arnold, 2009;Key et al, 2002) -potentially limit clinical applicability. Investigation of 7-keto DHEA may be an interesting alternative (Bicanic et al, 2013;Davidson et al, 2000). However, our results show alterations that differ during the day but seem to remain stable over disease states, suggesting that timing of administration could be important, both diurnally and during disease progression.…”

Section: Relevance and Implications For Research And Clinicmentioning

confidence: 99%

DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?

Mocking

Pellikaan

Lok

et al. 2015

Psychoneuroendocrinology

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Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder

Cited by 56 publications

References 36 publications

Adverse childhood experiences are associated with adult sleep disorders: a systematic review

Adverse childhood experiences are associated with adult sleep disorders: a systematic review

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

DHEAS and cortisol/DHEAS-ratio in recurrent depression: State, or trait predicting 10-year recurrence?

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