Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients

Chihaoui, Mélika; Madhi, W.; Yazidi, Mériem; Hammami, B.; Oueslati, I.; Khessairi, Nadia; Grira, W.; Bibi, Amina; Feki, Moncef; Chaker, Fatma

doi:10.1007/s12020-020-02452-9

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…During fasting, the levels of cortisol alter. Alterations differ based on measurement time ( 20 , 21 ). With regard to RF, there is a lack of information on how cortisol is altered during RF, particularly when fasting is performed in the summer time for about 17 to 18 h daily.…”

Section: Introductionmentioning

confidence: 99%

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

et al. 2021

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Ramadan fasting (RF) is a type of diurnal intermittent fasting. Previous studies reported the benefits of RF in healthy subjects on mood and health related to quality of life (QoL). Cortisol and brain-derived neurotrophic factor (BDNF) have been shown to play a role in mood, body composition parameters, and health-related QoL. This study aimed at elucidating the mechanism of the benefit of RF, particularly cortisol and BNDF and their association with mood and QoL. Insulin growth factor-1 (IGF-1), interleukin (IL)-8, matrix metalloproteinase (MMP)-9, and myoglobin were determined. Thirty-four healthy men and women were recruited. Serum from peripheral venous blood samples was collected at five time points: 1 week before RF (T1); mid of RF (T2), last days of RF (T3), 1 week after RF (T4), and 1 month after RF (T5). The amounts of biological mediators in the serum samples were determined by enzyme-linked immunosorbent assay (ELISA) and Luminex assays. BDNF and cortisol significantly decreased at T3 (p < 0.05) and T4 (p < 0.001) compared to T1, respectively. It seems the benefits of RF for mood-related symptoms are mediated by different biological mediators, particularly cortisol and BDNF.

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Section: Introductionmentioning

confidence: 99%

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

et al. 2021

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“…It is well known that cortisol levels change during fasting, and changes could differ depending on measurement time [ 29 , 30 ]. In one study, in women with polycystic ovarian syndrome, serum cortisol levels decreased after Ramadan compared to the beginning of Ramadan [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Improvement in endothelial function in hypertensive patients after Ramadan fasting: effects of cortisol

DEMİRCİ¹,

ÖZKAN²

2023

Turkish Journal of Medical Sciences

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Background/aim There are studies on the effects of Ramadan fasting (RF), which is one of the intermittent fasting diets, on both hypertension and endothelial function. However, the relationship between possible improvements in endothelial function and blood pressure after RF is not clear. In this study, we aimed to evaluate the effects of RF on blood pressure and endothelial dysfunction in patients with arterial hypertension (HT). Materials and methods Sixty-four HT patients, aged 45–65, who were followed up in the Cardiology Department of Kayseri City Hospital and fasted during Ramadan between 13 April and 13 May 2021 with their self-consents were enrolled to study. Body mass index (BMI), blood pressure, and flow-mediated dilatation (FMD) were assessed before and after Ramadan. Also, 5 mL venous blood samples were taken between 8:00 and 8:30 a.m. from all participants to assess cortisol, C-reactive protein (CRP), and other laboratory data. Results In patients, FMD values were found to be higher after Ramadan compared to values before the fasting period (p < 0.001). CRP and cortisol levels decreased after fasting, and the decrease in CRP (95% CI for B = −1.685 – −0.334, p = 0.009) and cortisol levels (95% CI for B = −0.392 – 0.092, p = 0.039) were determined as the predictive factors for FMD after RF. Conclusion Endothelial functions as determined by FMD improved after 30 days of intermittent fasting. The decreased CRP and cortisol levels may contribute to the improvement in FMD after RF.

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“…13190 nmol/l) that occurred three and four hours after Hc intake during intermittent fasting [15]. Maguire et al [16] reported very high SC levels (354, 956, and 1078 nmol/l) in three samples collected one hour after oral Hc intake in 22 children with SAI.…”

Section: Hydrocortisone Saliva Contaminationmentioning

confidence: 97%

“…This allows multiple sample collection by the patient itself and in ambulatory setting, while avoiding blood collection-related stress. However, some patients with AI treated with hydrocortisone (Hc) showed very high SC levels [11,12,[14][15][16][17], which was thought to result from saliva contamination after oral ingestion of Hc tablet. Solid reports evaluating saliva contamination are lacking in the literature.…”

Section: Introductionmentioning

confidence: 99%

Salivary Cortisol Measurement Contamination After Oral Hydrocortisone: A Randomized Crossover Trial

Chihaoui,

Mouelhi,

Hammami

et al. 2024

Horm Metab Res

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The study aimed to evaluate salivary cortisol (SC) contamination and determine the associated factors in secondary adrenal insufficiency (SAI) patients treated with hydrocortisone (Hc). A randomized crossover trial involved SAI patients. SC was measured before the morning Hc dose, then at one, two, and four hours after. The procedure was performed twice on two days of a week: one day while taking Hc in tablet form (tablet set) and one day while taking Hc in capsule form (capsule set). Area under the curve (AUC) of SC levels over time was calculated in each participant for the two sets. SC contamination was defined as AUCtablet above the 95th percentile of AUCcapsule. Thirty-four patients (24 females and 10 males) with a median age of 48 years were enrolled. Post-Hc dose SC levels were higher in tablet than in capsule set, particularly at one hour. Prevalence and extent of SC contamination were estimated to 32% and 88%, respectively. In capsule set, SC measured two hours after Hc intake showed the strongest correlation with AUC (r=0.88, p<0.001). In multivariate analysis, serum potassium≥3.9 mEq/l was the only predictor for SC contamination [multi-adjusted OR (95% CI): 7.1 (1.4–36.1); p=0.018]. SC measured during the two hours after Hc intake is inaccurate for glucocorticoid replacement therapy assessment in SAI patients treated with Hc in tablet form.

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Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients

Cited by 5 publications

References 40 publications

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

Ramadan Fasting in Germany (17–18 h/Day): Effect on Cortisol and Brain-Derived Neurotrophic Factor in Association With Mood and Body Composition Parameters

Improvement in endothelial function in hypertensive patients after Ramadan fasting: effects of cortisol

Salivary Cortisol Measurement Contamination After Oral Hydrocortisone: A Randomized Crossover Trial

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