Salivary Duct Carcinoma in Minor Salivary Glands: Report of Two Cases with Different Clinical Behavior

Gondak, Rogério; Mariano, Fernanda Viviane; Alves, Fábio Abreu; Almeida, Oslei Paes de; Lopes, Márcio Ajudarte

doi:10.4172/2161-0681.1000164

Cited by 4 publications

(4 citation statements)

References 48 publications

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“…[18] SDC typically exhibits an aggressive clinical course and unfavorable prognosis, with over 70% of patients succumbing within 3 years of initial diagnosis. [19] Notably, the overexpression of HER2/neu and p53 has been identified as an adverse prognostic factor for early regional recurrence, distant metastasis, and diminished overall survival. [20] Hassan et al reported a case involving delayed metastatic skin lesions at the primary site following total parotid gland excision, wherein the patient survived for over 6 years after the initial diagnosis before eventually succumbing to visceral metastases and associated complications.…”

Section: Discussionmentioning

confidence: 99%

Fingertip cutaneous metastasis of salivary duct carcinoma secondary to scald: A unique case report and a brief review of literature (following CARE guidelines)

Peng,

Wu,

et al. 2024

Medicine

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Rationale: Salivary duct carcinoma (SDC) is an aggressive form of cancer, with cutaneous metastasis being a rare occurrence. Furthermore, cutaneous metastasis of SDC secondary to a scald is even rarer, and to the best of our knowledge, our case represents the first such instance. Considering the involvement of the fingers in the metastatic site, which may affect limb function and quality of life, we present this case to explore the reason why scald could lead to distant recurrence and better treatment options. Patient concerns: An 85-year-old man diagnosed with SDC in the parotid gland found enlarged masses at the fingertips as a consequence of a burn, 6 years after his initial treatment. Diagnoses: Cutaneous metastasis of SDC in the parotid gland and left thumb loss due to surgery. Interventions: Radiotherapy was offered, targeting at the masses on the fingers, with dose at 15 Gy in 3 fractions, 12 Gy in 3 fractions, 15 Gy in 3 fractions for both hands and additional 21 Gy in 7 fractions only for left hand. Outcomes: The tumors shrank after 2 months of radiotherapy and the patient recovered well. Side effects included nail hyperplasia and paronychia. Lessons: Connections between scald and distant metastasis of malignant tumors in this case needed further investigation. Considering reserving function of the fingers while dealing with metastasis, radiotherapy is recommended rather than surgery.

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Section: Discussionmentioning

confidence: 99%

Fingertip cutaneous metastasis of salivary duct carcinoma secondary to scald: A unique case report and a brief review of literature (following CARE guidelines)

Peng,

Wu,

et al. 2024

Medicine

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“…Detection of SDC cells in the skin tissue several years after total tumorectomy is an extremely rare occurrence. SDC has a tendency to invade the surrounding tissue and has a high metastatic potential via the hematogenous and lymphatic pathways ( 4 , 7 ). SDC shows an aggressive clinical course with poor prognosis, and over 70% of patients die within 3 years after the primary diagnosis ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…SDC has a tendency to invade the surrounding tissue and has a high metastatic potential via the hematogenous and lymphatic pathways ( 4 , 7 ). SDC shows an aggressive clinical course with poor prognosis, and over 70% of patients die within 3 years after the primary diagnosis ( 7 ). Although our patient survived for more than 6 years after the primary diagnosis, he died due to late distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Salivary Duct Carcinoma with Late Distant Brain and Cutaneous Metastasis: A Case Report

et al. 2020

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Salivary duct carcinoma (SDC) is a rare and highly aggressive salivary gland tumor with poor prognosis, rapid growth, distant metastasis, early regional metastasis, and a high rate of recurrence. The parotid gland is the most common site of involvement, and the lungs and the bones are the most common sites of distant metastasis of SDC. Herein, we present a case of SDC of the parotid gland in a 62-year-old male patient with an unusual metastasis to the skin of the primary site and brain 6 years after primary treatment, which comprised of total parotidectomy and radical neck dissection followed by radiotherapy. It is noteworthy that in few cases of SDC with infiltration, (and not in low-grade intraductal carcinoma of the salivary glands), routine treatment may not suffice, and long-term follow-up is highly recommended.

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“…In addition, cases have been reported in the posterior mandible arising from the retromolar glands or ectopic salivary glands. [ 15 16 17 ] It is a high-grade malignant tumor which has propensity for invasive spread, perineural invasion with early locoregional and distant metastasis. [ 5 6 11 ] To confirm the origin of SDC within the jaw (intraosseous), there should be an intact cortical bone with no connection between the oral mucosal surface and the lesion and metastasis from other primary lesions should be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma in the mandibular anterior region: The role of immunohistochemical markers in its definitive diagnosis

Chandrasekar

Salati²,

Rao

et al. 2016

J Oral Maxillofac Pathol

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Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma arising from the ductal epithelium of salivary glands which rarely involves the minor salivary glands. The varied histological presentation in the minor salivary gland tumors makes them the most heterogeneous group of neoplasms, making the diagnosis a challenge. This report highlights the importance of immunohistochemical markers in the definitive diagnosis of SDC.

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Salivary Duct Carcinoma in Minor Salivary Glands: Report of Two Cases with Different Clinical Behavior

Cited by 4 publications

References 48 publications

Fingertip cutaneous metastasis of salivary duct carcinoma secondary to scald: A unique case report and a brief review of literature (following CARE guidelines)

Fingertip cutaneous metastasis of salivary duct carcinoma secondary to scald: A unique case report and a brief review of literature (following CARE guidelines)

Salivary Duct Carcinoma with Late Distant Brain and Cutaneous Metastasis: A Case Report

Salivary duct carcinoma in the mandibular anterior region: The role of immunohistochemical markers in its definitive diagnosis

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