Salivary duct carcinoma

Abstract

Twelve cases of salivary duct carcinoma were examined clinically, pathologically and by flow cytometry to quantify their histological features as well as attempt to identify factors predictive of patient outcome. All of the tumours arose in the parotid gland. Eight of the twelve patients were male. Four patients died of disease (median survival 12.5 months); three are alive with disease; and five are alive with no evidence of disease (mean follow-up of 50 months). Two tumours arose in a pre-existing pleomorphic adenoma. Positive lymph nodes were present in eight of ten patients sampled; patients with two or more positive lymph nodes tended to die of their disease or be alive with metastases. Comedo necrosis, perineural invasion and vascular invasion were common findings by light microscopy. Ten of the twelve tumours were aneuploid. Neither clinical stage, tumour size, aneuploidy nor histological features correlated with patient outcome. This study confirms the aggressive nature of salivary duct carcinoma.

Metastatic salivary duct carcinoma to the uterus: Report of a case diagnosed by cervical smear

“…[18][19][20] McKinney et al, 21 however, did not find a correlation between prognosis and tumor size, nodal metastasis, or local recurrence. Grenko et al 22 also did not find a correlation between prognosis and size of tumor, clinical stage, aneuploidy, histological features, lymph node metastasis, and vascular or perineural invasion.…”

Salivary Duct Carcinoma

“…21 It usually features variably sized cystic tumor nodules with characteristic central comedonecrosis. [1][2][3][4][5]7,10,13,[16][17][18]21,27 The epithelium of the nodules is arranged in papillary, cribriform and bandlike patterns. Often small bands of epithelium arch over luminal spaces to create a "Roman bridge" appearance.…”

“…Although salivary duct carcinoma has been regarded generally as a high grade malignancy, [1][2][3][4][5]7,10,13,[16][17][18]21,23,27 a recent histologic report describes 10 cases that are thought to represent the low grade counterpart of salivary duct carcinoma. 9 These tumors exhibit cystic nodules with micropapillary or plaquelike architecture and pseudocribriform nodules with slitlike spaces.…”

“…4 In addition to these intraductallike areas, some areas of salivary duct carcinoma usually show small, infiltrating cords and nests reminiscent of infiltrating carcinoma of the breast. [1][2][3][4][5]7,10,11,[16][17][18]21,23,27 Perineural infiltration and lymphatic invasion are frequently present.…”

“…[1][2][3][4][5]10,13,[16][17][18]21,23,27 Early diagnosis and treatment appear to be important as this tumor is known to metastasize early. 2,4,7,10,27 Although …”