Salivary duct carcinoma

Moriki, Toshiaki; Ueta, Shousuke; Takahashi, Tamotsu; Mitani, Miko; Ichien, Miho

doi:10.1002/cncr.9050

Cited by 112 publications

(11 citation statements)

References 25 publications

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“…The differential diagnosis for high-grade salivary duct carcinoma includes the papillary cystic and microcystic variants of acinic cell carcinoma, metastatic squamous cell carcinoma, metastatic breast cancer, melanoma, mucoepidermoid carcinoma, and oncocytic carcinoma. Based on nuclear findings, it may be possible to distinguish salivary duct carcinoma from other high-grade salivary gland carcinomas, by immunostaining for androgen receptor, gross cystic disease fluid protein-15 and p63 [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Behavior and Treatment-related Outcome of Rare Salivary Duct Carcinoma: The Shaukat Khanum Memorial Cancer Hospital Experience

Anwer

Faisal

Adeel

et al. 2018

Cureus

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BackgroundSalivary gland tumors are rare salivary gland malignancies with resemblance to ductal breast carcinoma. We have described clinicopathological behavior and treatment outcomes of this rare malignancy.MethodsSalivary duct carcinoma patients treated from 2010 to 2015 were retrospectively analyzed for clinicopathological characteristics and treatment-related outcomes of the disease.ResultsA total of 12 patients with salivary duct carcinoma were included in the study. All were males with mean age of 52.58 ± 13.43. Parotid gland was the most commonly involved major salivary gland while buccal mucosa and anterior tongue were most common oral cavity sub-sites involving minor salivary glands. The disease-free survival was 75% at 10 months and 25% at 20 months. The mean follow-up time was 12 months. There were three local recurrences and one distant metastasis.ConclusionSalivary duct carcinoma is a locally aggressive tumor with tendency for local recurrence and distant metastasis. Adverse features such as perineural invasion, extra-capsular spread and advanced nodal disease may worsen prognosis.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Behavior and Treatment-related Outcome of Rare Salivary Duct Carcinoma: The Shaukat Khanum Memorial Cancer Hospital Experience

Anwer

Faisal

Adeel

et al. 2018

Cureus

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“…[3] Expression of the oestrogen receptor is stated to be useful in the definitive diagnosis of these tumors, on cytology. [9] Salivary duct carcinoma is estrogen-receptor negative and occasionally progesterone-receptor positive. It shares most of the other markers of mammary carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Salivary duct carcinoma of parotid gland

Kinnera

Mandyam

Chowhan

et al. 2009

J Oral Maxillofac Pathol

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A 40-year old male presented with rapidly growing swelling in the right parotid region. Based on the fine needle aspiration cytology report of adenocarcinoma not otherwise specified, superficial parotidectomy was performed, which showed the features of salivary duct carcinoma by histopathological examination. The smears were reviewed to identify the potential pitfalls in the cytological diagnosis of salivary duct carcinoma.

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“…45.5% (5/11) of adenoid cystic carcinomas and 62.5% (5/8) of mucoepidermoid carcinomas showed MYB or MAML translocations, respectively (Figure 2 ). For the partially difficult differential diagnosis of SDC and adenocarcinoma NOS a diagnostic algorithm based on a characteristic „ductal“ growth pattern and the expression of the androgen receptor was employed [ 49 , 50 ]. Consistent with data published before, HER2 positivity, either by immuohistochemistry or by FISH, was detectable in a large subset of SDC but not in the tumors categorized as adenocarcinoma NOS [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity

et al. 2015

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Salivary gland cancer represents a heterogeneous group of malignant tumors. Due to their low incidence and the existence of multiple morphologically defined subtypes, these tumors are still poorly understood with regard to their molecular pathogenesis and therapeutically relevant genetic alterations.Performing a systematic and comprehensive study covering 13 subtypes of salivary gland cancer, next generation sequencing was done on 84 tissue samples of parotid gland cancer using multiplex PCR for enrichment of cancer related gene loci covering hotspots of 46 cancer genes.Mutations were identified in 22 different genes. The most frequent alterations affected TP53, followed by RAS genes, PIK3CA, SMAD4 and members of the ERB family. HRAS mutations accounted for more than 90% of RAS mutations, occurring especially in epithelial-myoepithelial carcinomas and salivary duct carcinomas. Additional mutations in PIK3CA also affected particularly epithelial-myoepithelial carcinomas and salivary duct carcinomas, occurring simultaneously with HRAS mutations in almost all cases, pointing to an unknown and therapeutically relevant molecular constellation. Interestingly, 14% of tumors revealed mutations in surface growth factor receptor genes including ALK, HER2, ERBB4, FGFR, cMET and RET, which might prove to be targetable by new therapeutic agents. 6% of tumors revealed mutations in SMAD4.In summary, our data provide novel insight into the fundamental molecular heterogeneity of salivary gland cancer, relevant in terms of tumor classification and the establishment of targeted therapeutic concepts.

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Salivary duct carcinoma

Cited by 112 publications

References 25 publications

Clinicopathological Behavior and Treatment-related Outcome of Rare Salivary Duct Carcinoma: The Shaukat Khanum Memorial Cancer Hospital Experience

Clinicopathological Behavior and Treatment-related Outcome of Rare Salivary Duct Carcinoma: The Shaukat Khanum Memorial Cancer Hospital Experience

Salivary duct carcinoma of parotid gland

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity

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