Salivary Duct Carcinoma Secreting Prostate-Specific Antigen

“…RT-PCR and other technologies have shown that most, if not all, human kallikreins are expressed in the salivary glands (James et al 1996;Diamandis and Yousef 2001;Yousef and Diamandis 2001;Petraki et al 2003). It is thus possible that some members of this family may be valuable biomarkers for differential diagnosis, subtyping, and monitoring of patients with salivary gland carcinomas.…”

mentioning

confidence: 99%

Human Kallikrein 6 Expression in Salivary Gland Tumors

Darling

Jackson-Boeters

Daley

et al. 2006

J Histochem Cytochem.

View full text Add to dashboard Cite

(EPD) S U M M A R Y Human kallikrein 6 (hK6), also known as zyme/protease M/neurosin), is expressed in many normal glandular tissues. The aim of this study was to determine whether hK6 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), using an immunohistochemical method. Pleomorphic adenomas (PA), adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined. Cells lining duct-like structures and non-duct-like cells were scored. Only in PA of minor salivary gland origin was overall staining higher in duct-like than in non-duct-like cells. In all other tumors exhibiting both types of cells, hK6 staining was similar in both duct-like and non-duct-like cells. Tumors that exhibited non-duct-like cells only also exhibited cytoplasmic staining. Results of this study show that salivary gland tumors express hK6, apparently downregulated in comparison with normal salivary gland tissue, and that this expression is not specific for any of the tumors studied.

show abstract

“…Several studies have shown that most human kallikreins are expressed in the salivary glands (1,2,9). It is thus possible that some members of this family may be valuable markers for differential diagnosis, subtyping and monitoring of patients with salivary gland carcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…PSA is known to be a kallikrein (11) and has been demonstrated in salivary gland tissues by means of in situ hybridization (12). James et al reported expression of hK3 in a salivary duct carcinoma (9).…”

Section: Introductionmentioning

confidence: 99%

Human Kallikrein 3 (prostate-specific antigen) and Human Kallikrein 5 Expression in Salivary Gland Tumors

et al. 2006

View full text Add to dashboard Cite

The human kallikrein 5 protein (hK5) is expressed in many normal tissues, most notably in skin, breast, salivary gland and esophagus. It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland. The aim of this study was to determine whether hK3 and hK5 are expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas and adenocarcinomas not otherwise specified of both minor and major salivary glands were examined

show abstract

Salivary Duct Carcinoma Secreting Prostate-Specific Antigen

Cited by 58 publications

References 9 publications

New diagnostic applications of prostate‐specific antigen

New diagnostic applications of prostate‐specific antigen

Human Kallikrein 6 Expression in Salivary Gland Tumors

Human Kallikrein 3 (prostate-specific antigen) and Human Kallikrein 5 Expression in Salivary Gland Tumors

Contact Info

Product

Resources

About