Salivary enzymes in peptic ulcer disease

Abstract

Peptic ulcerLactate dehydrogenase Peroxidase Amylase a b s t r a c t Aim: Peptic ulcer, the common disease of the upper gastro-intestinal tract, occurs in about 5e10% of the world's population. Therefore, diagnosis of trace disease progression with a noninvasive method is of prime importance in the field of healthcare research. The aim of this study was to evaluate the validity of salivary enzymes as noninvasive biomarkers for peptic ulcer. Materials and methods: In practice, 34 peptic ulcer patients and 30 healthy subjects donated their un-stimulated saliva samples after 8 h of fasting. The activity of some selected enzymes was measured using appropriate enzymatic assay methods. Results: The results indicated an overall alternation in enzymatic activity of saliva in patients suffering from peptic ulcer. Biological activity of a-amylase, peroxidase and lactate dehydrogenase, showed significantly higher values in almost all patients as compared to control subjects. Conclusions: Based on the results of salivary enzyme activity, it was concluded that besides the influence of their peptic ulcer on enzyme activity of saliva, the considerably higher activity of a-amylase could also be related to the major role of the enzyme on physiological oxidative stress.

Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management

“…Of those, salivary gland and pancreas secrete various enzymes and play multiple roles in the gastrointestinal tract, 105 , 106 and salivary enzymes have also been associated with some GI disorders, including PUD. 107 Because of the limited power of eQTL datasets (most tissues n < 500), we considered the SMR association with P SMR < 0.05 (nominally significant) and P HEIDI > 0.05 as significant in this study. Then, we determined if any SMR significant genes were shared between the diseases.…”

Alternations of salivary antioxidant enzymes in systemic lupus erythematosus

“…4 Salivary fluid protects the oral cavity against detritus agents such as microorganisms, toxins and various oxidants. 5 We have previously found that the biochemistry of human saliva is altered in response to external and internal factors such as smoking, 6 vegetarian diet, 7 peptic ulcer 8 and Ramadan fasting. 9 Other investigators have shown that in vitro exposure to cigarette smoke could significantly decrease biological activity of some enzymes, both in plasma and in saliva.…”

Evaluation of Salivary ?- Amylase Enzyme Activity in Smoker and Peptic Ulcer Patients affected by Periodontitis in Relation to Clinical Periodontal Parameters

“…Further support was obtained from other studies that indicated a potential relationship of PD with PUD [8] . Comparison of salivary enzymes between healthy subjects and patients with PUD showed that the latter group was associated with higher α-amylase activity compared to the control [9] . One of major risk factors for PUD is smoking which not only induce ulceration and increase acidity of the stomach but it was suggested as a predisposing factor for H. pylori gastric ulceration [10] .…”