Salivary flow, saliva, pH and buffering capacity in 70‐year‐old men and women

Abstract

A representative systematic selection of 30% of all 70-year-olds (1148 persons) in Göteborg were invited to a population study. The participation rate was 85%. Sixteen per cent of the men and 25% of the women reported dryness in the mouth (sex. diff. P less than 0.01). There was a significant correlation between the number of drugs consumed by the subjects and subjective dryness (in both sexes P less than 0.001). Intake of drugs from the groups of anticholionergics, antihistamines, sedatives, hypnotics or phenothiazines respectively seemed to have the highest predicative value for dryness in the mouth (men P less than 0.05 and women P less than 0.01). There was also a positive correlation between subjective dryness and number of definable diseases in both sexes (P less than 0.01). In a consecutive sample (fifty-eight men and fifty-three women) a study of salivary flow, direct pH and buffer effect were performed. The mean value of unstimulated salivary secretion was in men 0.25 and in women 0.18 ml/min. Corresponding figures for stimulated secretion was 1.65 and 1.04 ml/min (sex. diff. P less than 0.01). A significantly lower unstimulated secretion was noted in women with subjective dryness (P less than 0.01). A negative significant correlation were found between dental invalidity, according to Eichner's classification, and stimulated secretion when drug treatment had been considered (men P less than 0.05 and women P less than 0.01). Only weak relations were noted between salivary secretions and drug treatment. Only intake of drugs with diuretic effect were negatively correlated to stimulated secretion (P less than 0.01). Diseases of the circulatory system were correlated to subjective dryness (P less than 0.01).

The Effect of Chlorhexidine/Xylitol Chewing-Gum on Cariogenic Salivary Microf lora: A Clinical Trial in Elderly Patients

“…The salivary flow rates appeared low and the incidence of xeros tomia high when compared to other elderly groups [Rask et al, 1991;Hunt et al, 1992], The correlation between the prevalence of dry mouth and xerostomic medications is supported by other studies [Osterberg et al, 1984;Handelnian et al, 1989], Subjects in this study were able to relate low stimulated salivary flow rates to subjective perception of a dry mouth, which contrasts with other studies [Srccbny and Broich, 1988;Narhi, 1994],…”

Risk factors, hyposalivation and impact of xerostomia on oral health-related quality of life

“…27 Nederfors et al estimated the prevalence in the Swedish population to be 21.3% for men and 27.3% for women. 28 Österberg et al 29 and Locker 30 reported prevalence rates of 21% and 22.5% for men and women over 60 years, respectively.…”

Fluoride and Pilocarpine Reduce the Risk of Caries Produced by Chronic Clomipramine Treatment in Rats

“…Salivary gland hypofunction resulting from systemic disease, radiation therapy or use of specific medications significantly increases the risk of developing caries and oth er diseases of the oral cavity [Osterberg et al, 1984;Mandel, 1989;Lucas, 1993]. The secondary effects of certain drugs that are frequently prescribed in an adult population are among the most common causes of xerostomia [Winer and Bahn, 1967;Bertram et al, 1979;Rundegren et al, 1985;Handelman et al, 1986] due to their anticholinergic effects.…”