Salivary gland protection by amifostine in high-dose radioiodine therapy of differentiated thyroid cancer

Bohuslavizki, K. H.; Klutmann, Susanne; Bleckmann, C.; Brenner, Winfried; Lassmann, S.; Mester, János; Henze, Eberhard; Clausen, M.

doi:10.1007/bf02753843

Cited by 47 publications

(19 citation statements)

References 22 publications

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“…Intravenous amifostine, an organic thiophosphate, is a recent addition to the drug armamentarium to combat the effects of irradiation [54][55][56][57]. Within the tissues, amifostine undergoes dephosphorylation to its active metabolite WR-1065.…”

Section: Strategies For Prevention and Treatmentmentioning

confidence: 99%

RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

Jeong

Lee

2010

Nucl Med Mol Imaging

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Radioactive iodine ((131)I) is accumulated in the thyroid tissue and plays an important role in the treatment of differentiated papillary and follicular cancers after thyroidectomy. Simultaneously, (131)I is concentrated in the salivary glands and secreted into the saliva. Dose-related damage to the salivary parenchyma results from the (131)I irradiation. Salivary gland swelling and pain, usually involving the parotid, can be seen. The symptoms may develop immediately after a therapeutic dose of (131)I and/or months later and progress in intensity with time. In conjunction with the radiation sialadenitis, secondary complications reported include xerostomia, taste alterations, infection, increases in caries, facial nerve involvement, candidiasis, and neoplasia. Prevention of (131)I sialadenitis may involve the use of sialogogic agents to hasten the transit time of the radioactive iodine through the salivary glands. However, studies are not available to delineate the efficacy of this approach. Treatment of the varied complications that may develop encompass numerous approaches and include gland massage, sialogogic agents, duct probing, antibiotics, mouthwashes, good oral hygiene, and adequate hydration. Recently interventional sialoendoscopy has been introduced an effective tool for the management of patients with (131)I-induced sialadenitis that is unresponsive to medical treatment.

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Section: Strategies For Prevention and Treatmentmentioning

confidence: 99%

RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

Jeong

Lee

2010

Nucl Med Mol Imaging

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“…Hier ist die Angabe der Spannweite angezeigt. Bei sechs Publikationen (4%; 1%-10%) wird die Standardabweichung angegeben, obwohl das 95%-Konfidenzintervall oder wenigstens der Standardfehler sinnvoller gewesen wären [24,38,54,78,135,154].…”

Section: Qualitätsanalyse Der Zeitschrift "Strahlentherapie Und Onkolunclassified

Konfidenzintervalle und ihre Bedeutung für die Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

Beck‐Bornholdt

Dubben²

2000

Strahlenther Onkol

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“…Several clinical phase-II studies have demonstrated some clinical efficacy of amifostine [1,3,4,9,[11][12][13]. A recent randomized study has investigated the effect of amifostine in patients undergoing definitive or postoperative radiotherapy for head-and-neck cancers [10].…”

mentioning

confidence: 99%

Intermittent Use of Amifostine during Postoperative Radiochemotherapy and Acute Toxicity in Rectal Cancer Patients

Dunst

Semlin²,

Pigorsch³

et al. 2000

Strahlenther Onkol

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Salivary gland protection by amifostine in high-dose radioiodine therapy of differentiated thyroid cancer

Abstract: Parenchymal damage in salivary glands induced by high-dose radioiodine treatment can be reduced significantly by amifostine. This may help to increase patients' quality of life in differentiated thyroid cancer.

Cited by 47 publications

References 22 publications

RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

RETRACTED ARTICLE: Radiation Sialadenitis Induced by High-dose Radioactive Iodine Therapy

Konfidenzintervalle und ihre Bedeutung für die Beurteilung von Resultaten Qualitätsanalyse der Zeitschrift “Strahlentherapie und Onkologie”

Intermittent Use of Amifostine during Postoperative Radiochemotherapy and Acute Toxicity in Rectal Cancer Patients

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