Salivary Gland Tumors: a Ten-Year Retrospective Analysis in a Brazilian Teaching Hospital

Ribeiro, Alice Santana Valadares; Carvalho, Ana Luísa Saraiva Homem de; Koth, Valesca Sander; Campos, Maria Martha

doi:10.32635/2176-9745.rbc.2021v67n4.1452

Cited by 3 publications

(5 citation statements)

References 35 publications

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“…Iraqi research and further international multicenter studies have illustrated the high prevalence of these tumors in older age groups [29,31]; meanwhile, this difference could be related to the large sample size and broad range of histological subtypes included in these epidemiological studies. The present investigation revealed a higher incidence of PAs among the female population and at the parotid gland, which are similar findings to those of other clinicopathological datasets [29,32]. Malignant tumors were observed more in the palates of female patients.…”

Section: Discussionsupporting

confidence: 91%

“…Malignant tumors were observed more in the palates of female patients. However, previous studies support an increased prevalence among female patients, but with different site distributions in the parotid region [32], and presence in the minor salivary glands [29,33].…”

Section: Discussionmentioning

confidence: 87%

“…The available clinicopathological data (sex, age, site, tumor size, and lymph node status) were obtained from patients' reports. The patients were divided into three age groups: (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40), (41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60), (61-80). The diagnosis was confirmed by a newly prepared H&Estained tissue section, and CD117 immunostaining positivity was applied to verify the diagnosis of AdCC.…”

Section: Study Population and Designmentioning

confidence: 99%

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CD3 and CD20 Expressions and Infiltrating Patterns in Salivary Gland Tumors

Hussein,

Garib

2024

Diagnostics

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Tumor-infiltrating lymphocytes (TILs) represent a subset of immunological constituents within the tumor microenvironment that can influence cancer growth. We retrospectively evaluate the density and pattern of CD3 and CD20 expression in salivary gland tumors and their relation to clinical pathologic parameters. A total of 44 formalin-fixed paraffin-embedded blocks of salivary gland tumors were included. These tumors were stained immunohistochemically with CD3 and CD20. The chi-square test was used to relate immune scoring, intensity, and clinical pathological parameters to different salivary tumors. p-value < 0.05 was considered statistically significant. The intra-tumoral CD3 infiltrating count was high and diffused in (71.4%) of pleomorphic adenomas (PAs) followed by mucoepidermoid carcinomas (MECs) (66.7%). At the same time, adenoid cystic carcinomas (AdCCs) exhibited significantly low infiltration (71.4%) (p = 0.046). The three types of tumors exhibited high tumor-infiltrating counts diffused in peripheral areas with significant differences between malignant tumors (p = 0.047). The intra-tumoral CD20 infiltrating count significantly differed among the tumors (p = 0.002); it was low in all PAs and AdCCs, while MECs showed an equal percentage of expression. However, in the peripheral area, PAs and MECs exhibited significantly (p = 0.007) high infiltrating counts (69.2% and 84.6), and the lowest infiltrating count was predominantly found for AdCCs. The two markers had a significant positive correlation between the mean of CD3 in the intra-tumoral and peripheral regions and CD20 in the peripheral zone across the total samples. In conclusion, the density of CD3 expression is notably higher than CD20 across tumor types. PAs and MECs showed high-density scores, while AdCCs were characterized by low scores. TIL expression was found to be significantly associated with patients’ outcomes in the intra-tumoral area.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 87%

Section: Study Population and Designmentioning

confidence: 99%

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CD3 and CD20 Expressions and Infiltrating Patterns in Salivary Gland Tumors

Hussein,

Garib

2024

Diagnostics

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“…The maxilla was the most detected site. Conflicting findings were reported by other research that showed female preference, with different site distributions, which were the parotid region, 23 and minor salivary glands. 21 , 22 This difference could be attributed to the large sample size, and more histological subtypes were included in these epidemiological studies.…”

Section: Discussioncontrasting

confidence: 66%

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Mohammad¹,

Ibraheem²,

Khudair³

et al. 2023

IJGM

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Background Salivary tumors have various morphological features and might share some histopathological findings. They are considered a problematic area in diagnosis due to complex clinicopathological features and different biological behavior. Objective To identify the pathological behavior of salivary tumors immunohistochemically. Methodology This retrospective study involved thirty formalin-fixed paraffin-embedded blocks of salivary gland tumors. These tumors were stained immunohistochemically with syndecan-1 and cyclin D1. Chi-Square test was used to relate immunoscoring, intracellular localization, intensity, and invasion to different salivary tumors. The correlation of these two markers was done by spearman‘s rho test. P-value <0.05 was considered statistically significant. Results The mean age of the patients was 48.69 ± 17.7. The parotid gland was the most commonly reported site in benign tumors, and regarding malignant tumors, maxilla was the most prevalent site. Syndecan-1 in benign tumors showed a predominate score 3, most widely detected in pleomorphic adenoma. Malignant salivary tumors showed 89.4% positive expression with a more frequent score 3, most commonly found in adenocystic carcinoma. Cyclin D1 expressed in all benign salivary tumors, with prominent diffuse mixed intracellular localization in pleomorphic adenoma. Malignant tumors revealed an expression of 94.7%. Moderate scoring with mixed intracellular localization was recorded in adenocystic carcinoma, followed by mucoepidermoid carcinoma. There was a significant correlation between the two markers in response to the distribution of immunostaining in different cell compartments. Conclusion Syndecan-1 and cyclin D1 showed a significant combined role in salivary tumor progression. Interestingly notable ductal-myoepithelial cells affect epithelial morphogenesis, and growth of pleomorphic adenoma was observed. Furthermore, basophilic cells of cribriform adenocystic carcinomas might control the aggressiveness and proliferation rate of these tumors.

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“…The incidence of malignant neoplasms of the salivary glands varies among different researchers, with an estimated incidence of 0.4–2.6:100,000. They account for 3–6% of head and neck malignancies and less than 1% of all malignancies [ 1 , 2 , 3 ]. Despite their rarity, salivary gland neoplasms exhibit a diversity that is arguably unmatched by any other organ [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Salivary Gland Cancer: Correlation with the Biological Behavior

et al. 2023

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Salivary gland neoplasms comprise a diverse group of tumors with different biological behaviors and clinical outcomes. Understanding the underlying molecular alterations associated with these malignancies is critical for accurate diagnosis, prognosis, and treatment strategies. Among the many biomarkers under investigation, epithelial cell adhesion molecule (EpCAM) has emerged as a promising candidate in salivary gland cancer research. This article aims to provide a comprehensive overview of the differential expression of EpCAM in salivary gland cancer and its potential correlation with the biological behavior of these tumors. The clinical characteristics of 65 patients with salivary gland malignancy of different histopathological subtypes were included. We report the differential expression of EpCAM and the relationship between the clinical and histopathologic features of these tumors. Regarding the evaluation of the effect of EpCAM expression on survival, in our study, we showed that tumors with high EpCAM expression had reduced disease-free survival (DFS) and overall survival (OS) (p < 0.001) compared to patients with cancers with low EpCAM expression. In addition, the concurrent presence of perineural invasion and positive EpCAM expression appeared to be associated with shorter disease-free survival and overall survival. In conclusion, our study confirmed the prognostic value of detecting perineural invasion and EpCAM expression.

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Salivary Gland Tumors: a Ten-Year Retrospective Analysis in a Brazilian Teaching Hospital

Cited by 3 publications

References 35 publications

CD3 and CD20 Expressions and Infiltrating Patterns in Salivary Gland Tumors

CD3 and CD20 Expressions and Infiltrating Patterns in Salivary Gland Tumors

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Salivary Gland Cancer: Correlation with the Biological Behavior

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