Salivary high‐sensitivity cardiac troponin T levels in patients with acute myocardial infarction

Abstract

Results suggest that salivary hs-cTnT can be used as an alternative to serum hs-cTnT for diagnosis and monitoring of myocardial infarction.

Saliva as a diagnostic tool for oral and systemic diseases

“…33 Salivary cTn levels were shown to be a monitoring/diagnosis tool as sensitive as their serum levels in patients suffering from AMI. 34 There is little doubt that salivary tests will progressively replace blood samples to isolate several biomarkers associated with cardiovascular diseases.…”

Realising the Potential of Urine and Saliva as Diagnostic Tools in Sport and Exercise Medicine

“…Similarly, cardiac troponin T and creatine kinase-MB have also been used in a clinical context to provide information regarding cardiovascular stress [202] and muscle damage [203], respectively, and may become useful in exercise medicine as non-invasive alternatives. Furthermore, specific interleukins (ILs) have been identified in saliva [204,205], although their relationship to blood concentrations remains unclear.…”

Serum and salivary cardiac analytes in acute myocardial infarction related to oral health status

“…Additionally, we and others have extended these findings by evaluating the same biomarkers in saliva from control and AMI patients. [12][13][14][15][16] The results support the utility of select cardiac biomarkers detected in saliva to discriminate AMI from control subjects, and a positive relationship of specific cardiovascular-related analytes in serum and saliva.…”

“…However, recent reports by Mirzaii-Dizgah and Riahi demonstrated significant elevations in cardiac troponin T and TNI in AMI patients using an high-sensitivity ELISA. 15,16 The salivary specimens were obtained and stored somewhat differently from those reported here, it is unclear the timeframe within which the samples were evaluated, thus storage effects could also explain this contrasting outcome, and we recruited both STEMI (EKG positive) and NSTEMI (non-EKG positive) AMI patients, while their data only reports on STEMI patients. In contrast, CRP, a marker of systemic inflammation, was significantly higher in saliva of AMI patients and correlated positively with serum concentrations.…”

“…A Luminex IS-100 instrument was used to detect levels of C-reactive protein (CRP) (Millipore, St. Charles, MO, USA). 16 All samples were analyzed in duplicate within three months of collection.…”