Salivary IgG and IgA before and after periodontal therapy

Basu, M. K.; Glenwright, H. D.; Fox, E. C.; Becker, Jürgen

doi:10.1111/j.1600-0765.1976.tb00074.x

Cited by 13 publications

(7 citation statements)

References 8 publications

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“…Human whole saliva consists of the pooled secretions of major and rninor salivary glands together with crevicular fluid. We wanted to learn whether significant amounts of IgG come from other sites than the gingival crevices (7,8,(12)(13)(14). We therefore selected edentulous old people and predetitate babies and cotnpared them with dentate adults and dentate old people.…”

Section: Results Andl Discussionmentioning

confidence: 99%

Salivary immunoglobulin concentrations in predentate and edentulous mouths

Grönblad

Lindholm

1987

European J Oral Sciences

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— The concentrations of IgA, IgG and IgM in whole saliva of predentate babies, dentate adults, and edentulons old people, and the salivary IgG concentration of dentate old people, were determined using a solid phase radioimmunoassay. A highly significant difference in IgG concentratiorms was found between toothYess and dentate people. The average IgG concentrarion in the saliva of edentulous old people was 5.2 q/l, which was about 20° of that of dentate old people. The salivary IgG content of babies was only 1.7 q/I, which was in corxordance with the lovv postnatal serum IgG values. The salivary IgA level in this age group was also low. The edentulous old people tended to have decreased IgM values, and the predentate babies tended to have increased IgM values compared with the dentate adults.

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Section: Results Andl Discussionmentioning

confidence: 99%

Salivary immunoglobulin concentrations in predentate and edentulous mouths

Grönblad

Lindholm

1987

European J Oral Sciences

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“…Other early saliva‐based investigations detected significantly increased levels of collagenase 2 (MMP‐8) in periodontally diseased patients 57 . Subsequent explorations of immunoglobulins found in whole saliva directed against periodontal pathogens have indicated some correlations with the status of periodontal disease 58–61 . Although saliva‐based clinical testing shows much potential, more‐extensive research is required to identify the best candidate markers that can be simultaneously evaluated to obtain a profile for diagnosis, monitoring, and prediction of oral diseases.…”

Section: Oral Fluid Biomarkers Of Periodontal Diseasementioning

confidence: 99%

Oral Fluid–Based Biomarkers of Alveolar Bone Loss in Periodontitis

Kinney

Ramseier

Giannobile

2007

Annals of the New York Academy of Sciences

184

171

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: Periodontal disease is a bacteria‐induced chronic inflammatory disease affecting the soft and hard supporting structures encompassing the teeth. When left untreated, the ultimate outcome is alveolar bone loss and exfoliation of the involved teeth. Traditional periodontal diagnostic methods include assessment of clinical parameters and radiographs. Though efficient, these conventional techniques are inherently limited in that only a historical perspective, not current appraisal, of disease status can be determined. Advances in the use of oral fluids as possible biological samples for objective measures of current disease state, treatment monitoring, and prognostic indicators have boosted saliva and other oral‐based fluids to the forefront of technology. Oral fluids contain locally and systemically derived mediators of periodontal disease, including microbial, host‐response, and bone‐specific resorptive markers. Although most biomarkers in oral fluids represent inflammatory mediators, several specific collagen degradation and bone turnover‐related molecules have emerged as possible measures of periodontal disease activity. Pyridinoline cross‐linked carboxyterminal telopeptide (ICTP), for example, has been highly correlated with clinical features of the disease and decreases in response to intervention therapies, and has been shown to possess predictive properties for possible future disease activity. One foreseeable benefit of an oral fluid–based periodontal diagnostic would be identification of highly susceptible individuals prior to overt disease. Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost‐effective treatment therapies.

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“…For these patients, immunoglobulin levels in saliva proved to be a better indicator of the local response than the serum titer. In a study of whole saliva collected from 12 patients with periodontal disease, the IgG concentration in saliva was found to be increased and IgA concentration decreased before periodontal therapy as compared to post-treatment levels (Basu et al 1976). Furthermore, salivary levels of IgG and IgA were found to be higher in a group of 50 NIDDM patients with periodontitis, as compared with 50 non-diabetic periodontitis patients, and 50 age and gender-matched healthy controls.…”

Section: Immunoglobulin Isotypes In Salivamentioning

confidence: 99%

Analysis of saliva for periodontal diagnosis

Kaufman

Lamster

2000

J Clinic Periodontology

337

293

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A number of markers show promise as sensitive measures of disease and the effectiveness of therapy. At this time, host-derived enzymes and other inflammatory mediators orginating from the gingival crevice appear to hold the greatest promise as salivary diagnostic tests for periodontal disease. Longer-term longitudinal studies, however, are required to establish the relationship between specific markers and progression of periodontal disease. Furthermore, analysis of saliva may offer a cost-effective approach to assessment of periodontal disease in large populations.

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Salivary IgG and IgA before and after periodontal therapy

Cited by 13 publications

References 8 publications

Salivary immunoglobulin concentrations in predentate and edentulous mouths

Salivary immunoglobulin concentrations in predentate and edentulous mouths

Oral Fluid–Based Biomarkers of Alveolar Bone Loss in Periodontitis

Analysis of saliva for periodontal diagnosis

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