“…There is evidence of the association between the salivary levels of these enzymes and periodontitis (Alptekin, Kurtoglu, Serpek, Duran, & Gözlü, 2000;Cesco, Ito, & de Albuquerque, 2003;Fiorellini, Nevins, Sekler, Chung, & Oringer, 2000;Kugahara, Shosenji, & Ohashi, 2008;Totan, Greabu, Totan, & Spinu, 2006), while the activity of ALT, AST and LDH tends to decrease in saliva after nonsurgical treatment of periodontitis (Yoshie et al, 2007). Higher levels of salivary LDH, AST, and ALT were attributed to autoimmunological damage associated with the pathophysiology of diabetes mellitus (Malicka, Skoskiewicz-Malinowska, & Kaczmarek, 2016) and are therefore considered for monitoring the diabetic involvement of salivary glands (Musumeci et al, 1993;Verma et al, 2014). Furthermore, higher levels of salivary AST, and ALT may help with the early diagnosis of peptic ulcer (Boghori, Aghamaali, Sariri, Mohamadpour, & Ghafouri, 2014).…”