Salivary MMP‐13 gender differences in periodontitis: A cross‐sectional study from Sweden

Virtanen, Eunice; Yakob, Maha; Tervahartiala, Taina; Söder, Per‐Östen; Andersson, Leif C.; Sorsa, Timo; Meurman, Jukka H.; Söder, Birgitta

doi:10.1002/cre2.76

Cited by 9 publications

(7 citation statements)

References 35 publications

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“…Still, there is some controversy over whether salivary MMP-9 levels are higher in patients with periodontitis. In a recent study of patients with and without periodontitis, no significant differences between the groups were found in either serum or salivary levels of MMP-9 [33]. Another limitation of our study is that we were unable to evaluate the impact of potential confounders, such as smoking, due to small sample size.…”

Section: Discussionmentioning

confidence: 84%

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

et al. 2019

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BackgroundLow-grade systemic inflammation is a predictor of recurrent cardiac events in patients with coronary artery disease (CAD). Plasma proteins such as matrix metalloproteinase (MMP)-9 and myeloperoxidase (MPO) have been shown to reflect basal as well as stress-induced inflammation in CAD. Measurements of MMP-9 and MPO in saliva might pose several advantages. Therefore, we investigated whether salivary levels of MMP-9 and MPO corresponded to plasma levels in patients with coronary artery disease (CAD), both at rest and after acute physical exercise.MethodsA bicycle ergometer test was used as a model for stress-induced inflammation. Twenty-three CAD patients performed the test on two occasions 3–6 months apart. Whole unstimulated saliva was collected before, directly after and 30 min after exercise while plasma was collected before and after 30 min. MMP-9 and MPO in saliva and plasma were determined by Luminex.ResultsMMP-9 and MPO levels were 2- to 4-fold higher in saliva than in plasma. Amongst the saliva samples, and also to a great extent amongst the plasma samples, the levels of both types of protein showed strong intercorrelations between the levels at rest and after exercise during the two visits. However, there were no (or weak) correlations between salivary and plasma MMP-9 and none between salivary and plasma MPO.ConclusionWe conclude that salivary diagnostics cannot be used to assess systemic levels of MMP-9 and MPO in CAD patients, neither at rest nor after acute physical exercise.

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Section: Discussionmentioning

confidence: 84%

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

et al. 2019

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“…Still, there is some controversy over whether salivary MMP-9 levels are higher in patients with periodontitis. In a recent study of patients with and without periodontitis, no significant differences between groups were found in either serum or salivary levels of MMP-9 [30]. Another limitation of our study is the small sample size not allowing us to evaluate the impact of potential confounders, such as smoking.…”

Section: Discussionmentioning

confidence: 85%

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

Mahmood

Enocsson

Bäck

et al. 2018

Preprint

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22 Background 23 Low-grade systemic inflammation is a predictor of recurrent cardiac events in patients with coronary 24 artery disease (CAD). Plasma proteins such as matrix metalloproteinase (MMP)-9 and 25 myeloperoxidase (MPO) have been shown to reflect basal as well as stress-induced inflammation in 26 CAD. Measurements of MMP-9 and MPO in saliva might pose several advantages. Therefore, we 27 investigated whether salivary levels of MMP-9 and MPO corresponded to plasma levels in patients 28 with CAD, both at rest and after acute physical exercise. 29 Methods 30 An acute bout of physical exercise on a bicycle ergometer was used as a model for stress-induced 31 inflammation. Twenty-three CAD patients performed the test on two occasions 3-6 months apart. 32 Whole unstimulated saliva was collected before, directly after and 30 min after exercise while plasma 33 was collected before and after 30 min. MMP-9 and MPO in saliva and plasma were determined by 34 Luminex. 35 Results 36 MMP-9 and MPO levels were 2-to 4-fold higher in saliva than in plasma. Within the saliva 37 compartment, and also to a great extent within the plasma compartments, MMP-9 and MPO showed 38 strong intercorrelations at all time points. However, there were no (or weak) correlations between 39 salivary and plasma MMP-9 and none between salivary and plasma MPO. 40 Conclusion 41 We conclude that salivary diagnostics cannot be used to assess systemic levels of MMP-9 and MPO in 42 CAD patients, neither at rest nor after acute physical exercise. 43 44 Key words 45 Coronary artery disease; inflammation; matrix metalloproteinase-9; myeloperoxidase; saliva 46 3 47 Introduction 48 49 Inflammation is an important component of atherosclerosis, from the formation of atherosclerotic 50 plaques to plaque destabilization eventually leading to plaque rupture and atherothrombotic events, 51 such as myocardial infarction [1]. Systemic levels of inflammatory markers can be useful to assess 52 cardiovascular risk and monitor disease activity and over the years, great efforts have been made to 53 identify relevant and easily available markers. The predictive value of markers like C-reactive protein 54 (CRP) and interleukin (IL)-6 in determining the risk of myocardial infarction is well-documented [2].55 Moreover, a number of epidemiological and clinical studies have shown that neutrophil-associated 56 proteins in plasma, such as matrix metalloproteinase (MMP)-9 and myeloperoxidase (MPO), predict 57 cardiovascular outcome [3, 4] and also relate to the extent and severity of atherosclerosis [5]. Overall, 58 there is emerging evidence that the presence of low-grade systemic inflammation should be considered 59 in clinical praxis when assessing a patient´s risk of recurrent cardiovascular events. 60 61 Low-grade inflammation is however not always detectable in plasma measures taken at rest. As has 62 been shown in various settings, stress provocation tests may add important information on the 63 individual´s susceptibility to inflammatory response [6][7][8][9]. A gr...

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“…Other researchers such as Virtanen et al [66] continued to look for other metalloproteinases as potential biomarkers, and some reaffirm that the salivary concentrations of matrix metalloproteinases such as MMP-8 and MMP-9 are slightly higher in patients with periodontitis, although they report that the differences between the groups were not significant. Interestingly, this group reports that MMP-13 values were significantly higher in the group without periodontitis compared to patients with periodontitis and also report that the concentration of MMP-13 may have some gender implications in periodontitis.…”

Section: Metalloproteinasesmentioning

confidence: 99%

Use of Biomarkers for the Diagnosis of Periodontitis

González-Ramírez¹,

Serafín-Higuera²,

Mancilla³

et al. 2020

Periodontal Disease - Diagnostic and Adjunctive Non-Surgical Considerations

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Periodontal disease is the most common oral condition of human population; if periodontitis is not treated in its initial stages, it can cause the loss of teeth. The diagnosis of periodontitis is based on clinical measurements. However, currently with the advancement of technology, other diagnostic and monitoring options are being search. In fact, different types of biomarkers have been evaluated where different biological fluids have been used as a source of the sample. We will try to summarize existing biomarkers of different periodontitis stages and make a comparison of the periodontal biomarkers evaluated so far and their usefulness in diagnosis and monitoring of periodontitis.

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Salivary MMP‐13 gender differences in periodontitis: A cross‐sectional study from Sweden

Cited by 9 publications

References 35 publications

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease

Use of Biomarkers for the Diagnosis of Periodontitis

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