Comprehensive Physiology 1989
DOI: 10.1002/cphy.cp060305
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Salivary Mucin Secretion

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Cited by 8 publications
(4 citation statements)
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“…Because kallikreins are produced by ductal cells (Schachter, 1980) and cystatins are products of acinar cells of submandibular glands (Cohen et al, 1990), these observations suggest that there may be a differential control of secretion of proteins synthesized by ductal and acinar cells. The secretion of many ductal proteins such as epidermal growth factor, nerve growth factor, renin-like enzymes, and kallikrein appears to be initiated by a-adrenergic receptors (Orstavik and Gautvik, 1977;Wallace and Partlow, 1976;Hirata and Orth, 1980), whereas the synthesis and secretion of acinar cell products is regulated by ,-adrenergic receptors (Johnson and Cortez, 1988;Quissell and Tabak, 1989). The significance of these differences and the mechanisms that control the differential regulation of these proteins is not clear at this time and further studies are needed.…”
Section: Discussionmentioning
confidence: 99%
“…Because kallikreins are produced by ductal cells (Schachter, 1980) and cystatins are products of acinar cells of submandibular glands (Cohen et al, 1990), these observations suggest that there may be a differential control of secretion of proteins synthesized by ductal and acinar cells. The secretion of many ductal proteins such as epidermal growth factor, nerve growth factor, renin-like enzymes, and kallikrein appears to be initiated by a-adrenergic receptors (Orstavik and Gautvik, 1977;Wallace and Partlow, 1976;Hirata and Orth, 1980), whereas the synthesis and secretion of acinar cell products is regulated by ,-adrenergic receptors (Johnson and Cortez, 1988;Quissell and Tabak, 1989). The significance of these differences and the mechanisms that control the differential regulation of these proteins is not clear at this time and further studies are needed.…”
Section: Discussionmentioning
confidence: 99%
“…This process is continuous in most cells (`constitutive' exocytosis), but it can be greatly accelerated following an appropriate cellular signal such as neural stimulation (`regulatory' exocytosis). In the three major salivary glands, parotid, submandibular and sublingual, exocytotic protein secretion is primarily controlled by the autonomic nervous system; sympathetic stimulation elicits protein release from parotid and submandibular gland acini, and parasympathetic stimulation elicits protein release from sublingual gland acini as well as some release from parotid acini (Quissell and Tabak, 1989; Spearman and Butcher, 1989). We will focus here on amylase secretion from rat parotid acinar cells as recent studies on this system are promoting a better understanding of the cellular events involved in salivary gland exocytosis.…”
Section: Salivary Protein Secretionmentioning
confidence: 99%
“…Mucin in salivary secretion is accompanied by epidermal growth factor (EGF), prosta glandins and various other nonmucin proteins [19][20][21][22][23][24][25][26], Secretion o f water and electrolytes, including buffers, by salivary glands is mediated by parasympathetic branches o f the autonomic nervous system, whereas secre tion o f organic components (salivary mucin, EGF. prosta glandins) is modulated by the adrenergic pathway [27], predominantly P-adrenergic [28]. Since the rate o f sali vary secretion and its composition is also greatly in fluenced by esophageal intraluminal mechanical (stroking o f the mucosa and stretching the wall by distention) and chemical stimuli (pH), its role in combating GER cannot be overestimated.…”
Section: Evolving Role Of Saliva In Esophageal Mucosal Protectionmentioning
confidence: 99%