Salivary Oxidative Stress Markers in Relation to Vascular Disease Risk of Type Two Diabetes Mellitus

Abstract

Background: Cardiovascular disease (CVD) is an important complication of type 2 diabetes mellitus (T2DM). Oxidative stress plays a major role in the development of CVD. Saliva has a diagnostic properties aiding in the detection of systemic diseases. This study aimed to assess the association between salivary oxidative stress markers and the risk of vascular disease (VD) in T2DM patients. Materials and Methods: One hundred T2DM patients and fifty apparently healthy males were enrolled in this study. Saliva sample was collected for assessment of oxidative stress markers including: lipid peroxidation plasma thiobarbituric acid-reactive substances (TBARS), uric acid (UA) and total antioxidant capacity (TAC) levels. Arterial stiffness index (ASI) was used for the assessment of VD risk. Results: According to ASI, T2DM patients were categorized into two groups: Group A: T2DM patients without VD risk. Group B: T2DM patients with VD risk. The mean values of TBARS and UA of group B showed a statistically highly significant elevation compared to group A and controls (P<0.01). The mean value of TAC of group B showed a statistically highly significant decrease when compared to group A and controls (P<0.01). Conclusion: The increase in salivary TBARS and UA levels and the decrease in the TAC level can be used as an indicator for the increase of risk for VD in T2DM patients.

Serum and salivary adiponectin levels as predictive markers for diabetes mellitus in children with a family history of diabetes

“…Saliva has dynamic diagnostic properties that enable the detection of oral and systemic diseases by analyzing salivary biomarkers [6]. Type 1 diabetes (T1DM), which can manifest at any age and accounts for 10 to 15% of all diabetes cases, is characterized by autoimmune processes involving islet-specific auto-reactive CD4+ and CD8+ T lymphocytes [7][8][9][10].…”