Objective: Toestimate the serum levels of soluble intercellular adhesion molecule-1 (s-ICAM-1) in children newly diagnosed with lymphoma and to correlate levels of s-ICAM-1 in lymphoma patients with clinical stage, pathological types, clinical and laboratory data and patient outcome. Subjects and Methods: Thirty-five children with newly-diagnosed malignant lymphoma (Non-Hodgkin’s lymphoma, NHL: 23), Hodgkin’s disease (HD: 12), and 8 apparently healthy subjects of matched age and sex taken as a control group were studied. For the patients and control group, the following tests were performed: complete blood count, and the following biochemical investigations: liver function tests, lactate dehydrogenase (LDH), and soluble ICAM-1 estimation using ELISA. In addition, for patients, pathological examination of lymph node biopsy for pathological grading, bone marrow aspiration and biopsy were done. Patients were observed for over 12 months or until death. Results: Serum ICAM-1 increased more in HD and NHL than in the control group (p < 0.000); also s-ICAM-1 increased in advanced stages and high-grade NHL (p < 0.008, 0.04, respectively). LDH levels were higher in patients compared to controls (p < 0.000). There was a positive correlation between high levels of s-ICAM-1 and increased levels of LDH in HD (r = 0.72, p < 0.008) and a positive correlation between high levels of s-ICAM-1 and increased ALT in NHL patients. A positive correlation between s-ICAM-1 levels and the presence of B symptoms in HD and NHL, and a positive correlation between elevated s-ICAM-1 levels and worse outcome in HD and NHL were detected. Conclusions: The data indicate that in children with malignant lymphoma, high serum levels of ICAM-1 correlated with tumor aggressiveness, and quantification of s-ICAM-1 levels may identify a subgroup of children with worse prognosis. Therefore, detection of s-ICAM-1 levels in children with malignant lymphoma might represent an additional disease-associated marker for use in the clinical management of the patients.

Diabetes mellitus (DM) is a systemic disease with several major complications. One of the important complications of diabetes mellitus is periodontal disease. The risk for this complication is not equal in all DM patients and thus some factors may increase its severity.To study the relationship between selected clinical characteristics and periodontal disease in type 2 (DM) patients.Two hundred and four type 2 diabetic patients were enrolled in this study; their ages were (28-71) years. The clinical characteristics included age, sex, body mass index (BMI), duration of (DM), smoking, and history of important diseases that complicate (DM) including hypertension, coronary heart disease, and arthritis. Periodontal status was evaluated by periodontal disease index (PDI) which included plaque, calculus, and periodontal components of this index. The means of plaque, calculus, and periodontal disease index were compared between patients who were grouped according to the presence or absence of the selected clinical characteristics.There was a significant difference in mean value of calculus index between hypertensive and non hypertensive patients (0.56±0.53 vs. 0.72±0.43, P< 0.05). Also there was a significant difference in periodontal disease index between hypertensive diabetic patient compared to diabetic patients who had no hypertension (3.84±0.75 vs. 3.2±0.99, P<0.001).Analysis of correlation showed that the correlations between plaque index and both calculus index and periodontal disease index were highly significant (P<0.001). The correlation was positive and highly significant between PDI and age (P<0.001) while it was significant between PDI and duration of DM ( P < 0.05 ).Hypertension seems to have a role in aggravating periodontitis in type 2 DM particularly with increasing age and duration of disease. Preventive periodontal disease programs should take in consideration presence of hypertension in type 2 DM.

Background: Cardiovascular disease (CVD) is an important complication of type 2 diabetes mellitus (T2DM). Oxidative stress plays a major role in the development of CVD. Saliva has a diagnostic properties aiding in the detection of systemic diseases. This study aimed to assess the association between salivary oxidative stress markers and the risk of vascular disease (VD) in T2DM patients. Materials and Methods: One hundred T2DM patients and fifty apparently healthy males were enrolled in this study. Saliva sample was collected for assessment of oxidative stress markers including: lipid peroxidation plasma thiobarbituric acid-reactive substances (TBARS), uric acid (UA) and total antioxidant capacity (TAC) levels. Arterial stiffness index (ASI) was used for the assessment of VD risk. Results: According to ASI, T2DM patients were categorized into two groups: Group A: T2DM patients without VD risk. Group B: T2DM patients with VD risk. The mean values of TBARS and UA of group B showed a statistically highly significant elevation compared to group A and controls (P<0.01). The mean value of TAC of group B showed a statistically highly significant decrease when compared to group A and controls (P<0.01). Conclusion: The increase in salivary TBARS and UA levels and the decrease in the TAC level can be used as an indicator for the increase of risk for VD in T2DM patients.

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