Salivary proteome analysis of crack cocaine dependents

Chaiben, Cassiano Lima; Batista, Thiago Beltrami Dias; Penteado, Carlos Antonio Schäffer; Barbosa, Maria Carolina Maciel; Ventura, Talita Mendes Oliveira; Dionízio, Aline; Rosa, Edvaldo Antônio Ribeiro; Buzalaf, Marília Afonso Rabelo; Azevedo‐Alanis, Luciana Reis

doi:10.1016/j.archoralbio.2020.104952

Cited by 3 publications

(4 citation statements)

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“…Biological fluids contain proteins and other molecules that can be used as biomarkers to detect the presence of psychoactive substances ("drug testing") [15,16], patterns of consumption [17] or to function as indicators of physiological processes or diseases, such as those related before or in response to a therapeutic agent [15,16,18]. Saliva, a transparent watery fluid secreted by the salivary glands directly into the oral cavity which contains more than 2,000 proteins and peptides involved in a variety of different oral biological functions, is an excellent diagnostic fluid [16].…”

Section: Marques Ss Et Almentioning

confidence: 99%

“…Saliva, a transparent watery fluid secreted by the salivary glands directly into the oral cavity which contains more than 2,000 proteins and peptides involved in a variety of different oral biological functions, is an excellent diagnostic fluid [16]. These proteins and peptides can be characterized and analyzed to monitor or identify various diseases by proteomic analysis in crack addicts [17].…”

Section: Marques Ss Et Almentioning

confidence: 99%

“…Crack cocaine users are especially vulnerable to dental caries, gingival inflammation, oral mucosa lesions and xerostomia [15][16][17]. Salivary biomarkers, due to their non-invasive nature and ability to detect drug metabolites, have shown promising potential for evaluating both crack cocaine use itself and some of its main complications, such as cancers and periodontal diseases [15,16].…”

Section: Marques Ss Et Almentioning

confidence: 99%

“…They offer a convenient and accessible method for monitoring drug exposure, assessing treatment progress and conducting research on drug use patterns. Saliva-based tests can provide real-time or recent drug use information and might help in early detection of crack cocaine abuse, intervention, and support for individuals struggling with addiction [17]. Further research and validation are needed to establish the reliability and accuracy of these biomarkers in specific contexts [15][16][17].…”

Section: Marques Ss Et Almentioning

confidence: 99%

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Unlocking the secrets of saliva: the promising potential of salivary biomarkers for evaluating crack use

MARQUES,

Oliveira,

ZUCCO

et al. 2023

Braz. Dent. Sci.

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The forthcoming letter will encompass the following highlights: Crack cocaine use involves smoking a highly addictive form of cocaine, which is a significant concern in Brazil, particularly in urban areas. This addiction is linked to various health problems, including cardiovascular issues, sexually transmitted infections (STIs) like AIDS and syphilis, tuberculosis, and a notable increase in mortality, largely due to violent causes. Furthermore, crack cocaine users are particularly vulnerable to dental caries, gingival inflammation, oral mucosa lesions, and xerostomia

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Section: Marques Ss Et Almentioning

confidence: 99%

Section: Marques Ss Et Almentioning

confidence: 99%

Section: Marques Ss Et Almentioning

confidence: 99%

Section: Marques Ss Et Almentioning

confidence: 99%

See 2 more Smart Citations

Unlocking the secrets of saliva: the promising potential of salivary biomarkers for evaluating crack use

MARQUES,

Oliveira,

ZUCCO

et al. 2023

Braz. Dent. Sci.

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show abstract

Photonic platform coupled with machine learning algorithms to detect pyrolysis products of crack cocaine in saliva: A proof-of-concept animal study

Santana-Melo,

Caixeta,

Aguiar

et al. 2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Salivary protein candidates for biomarkers of oral disorders in people with a crack cocaine use disorder

et al. 2023

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Salivary protein candidates for biomarkers of oral disorders in people with a crack cocaine use disorderThe use of cocaine and its main derivative, crack, can cause some systemic effects that may lead to the development of some oral disorders.Objective: To assess the oral health of people with a crack cocaine use disorder and identify salivary protein candidates for biomarkers of oral disorders.Methodology: A total of 40 volunteers hospitalized for rehabilitation for crack cocaine addiction were enrolled; nine were randomly selected for proteomic analysis. Intraoral examination, report of DMFT, gingival and plaque index, xerostomia, and non-stimulated saliva collection were performed. A list of proteins identified was generated from the UniProt database and manually revised. Results: The mean age (n=40) was 32 (±8.88; 18-51) years; the mean DMFT index was 16±7.70; the mean plaque and gingival index were 2.07±0.65 and 2.12±0.64, respectively; and 20 (50%) volunteers reported xerostomia. We identified 305 salivary proteins (n=9), of which 23 were classified as candidate for biomarkers associated with 14 oral disorders. The highest number of candidates for biomarkers was associated with carcinoma of head and neck (n=7) and nasopharyngeal carcinoma (n=7), followed by periodontitis (n=6). Conclusions: People with a crack cocaine use disorder had an increased risk of dental caries and gingival inflammation; less than half had oral mucosal alterations, and half experienced xerostomia. As possible biomarkers for 14 oral disorders, 23 salivary proteins were identified. Oral cancer and periodontal disease were the most often associated disorders with biomarkers.

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Salivary proteome analysis of crack cocaine dependents

Cited by 3 publications

References 36 publications

Unlocking the secrets of saliva: the promising potential of salivary biomarkers for evaluating crack use

Unlocking the secrets of saliva: the promising potential of salivary biomarkers for evaluating crack use

Photonic platform coupled with machine learning algorithms to detect pyrolysis products of crack cocaine in saliva: A proof-of-concept animal study

Salivary protein candidates for biomarkers of oral disorders in people with a crack cocaine use disorder

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