Salivary Secretion in Chronic Pancreatitis with Special Reference to Albumin and Lactoferrin

Dürr, G. H.-K.; Amouric, Michèle; Bode, Ch.; Jc, Bode; Sarles, H; Figarella, Catherine

doi:10.1159/000198781

Cited by 8 publications

(3 citation statements)

References 5 publications

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“…Albumin concentrations in saliva and other mucosal secretions reflect a passive contribution of serum-derived protein, which may be caused by epithelial inflammation. Changes in albumin content of saliva can be used as a diagnostic tool for certain diseases like chronic pancreatitis (Durr et al, 1982) and stomatitis in cancer therapy patients (Izutzu et al, 1981). In the saliva of orally healthy individuals, albumin can be detected in only very small amounts (Henskens et al, 1993).…”

Section: Albuminmentioning

confidence: 99%

Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids

Schenkels

Veerman

Amerongen

1995

Critical Reviews in Oral Biology & Medicine

319

238

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This paper describes several salivary components and their distribution in other mucosal secretions. Histatins are polypeptides which possess exceptional anti-fungal and anti-bacterial activities, but are nevertheless present only in saliva. Proline-rich proteins (PRPs) are members of a closely related family, of which the acidic PRPs are found solely in saliva, whereas the basic PRPs are also found in other secretions. Mucins are a group of glycoproteins that contribute to the visco-elastic character of the mucosal secretions. Despite the similarities in their structure and behavior, mucins have distinct tissue distributions and amino acid sequences. Other salivary proteins are present in one or more mucosal secretions. Lysozyme is an example of a component belonging to an ancient self-defense system, whereas secretory immunoglobulin A (sIgA) is the secreted part of a sophisticated adaptive immune system. Cystatins are closely related proteins which belong to a multigene family. Alpha-Amylase is a component that is believed to play a specific role in digestion, but is nevertheless present in several body fluids. Kallikrein and albumin are components of blood plasma. But whereas albumin diffuses into the different mucosal secretions, kallikrein is secreted specifically by the mucosal glands. The presence of these proteins specifically in saliva, or their distribution in other mucosal secretions as well, may provide important clues with respect to the physiology of those proteins in the oral cavity.

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Section: Albuminmentioning

confidence: 99%

Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids

Schenkels

Veerman

Amerongen

1995

Critical Reviews in Oral Biology & Medicine

319

238

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“…LF was analyzed in the duodenum be cause the duodenal content is easier to obtain routinely than pure pancreatic juice, but the duodenal LF may originate from the duode nal wall, pancreas, biliary tract, PMN as well as from gastric and salivary contaminations [3][4][5]. The degree of sensitivity of our immu noassay of LF is the same or higher than that of radioimmunoassay described in the litera ture [12], and about 1,000 times more ele vated than radial immunodiffusion [10,19].…”

Section: Discussionmentioning

confidence: 81%

Duodenal Lactoferrin in Patients with Chronic Pancreatitis and Gastrointestinal Diseases

Gaia¹,

Figarella²,

Piantino³

et al. 1985

Digestion

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Lactoferrin (LF), chymotrypsin and lipase activity were measured in duodenal juice during pancreatic stimulation. Secretin (0.5 CU/kg/h) plus cerulein (75 ng/kg/h) were infused intravenously in 98 subjects: 33 patients without organic diseases (C), 40 patients affected by chronic pancreatitis (CP), and 25 patients with different gastrointestinal diseases (GID). LF was determined by means of a new noncompetitive immunoenzymatic assay with a sensitivity in the duodenal juice of 5 ng/ml. Duodenal LF concentrations were significantly higher in CP than in C or GID (p < 0.001). LF was in a normal range in acute relapsing pancreatitis due to biliary stones or pancreas divisum. In the diagnosis of the chronic pancreatitis, LF/lipase ratios showed a specificity of 93% and a sensitivity of 95%. Our results show that LF immunoassay in duodenal juice is a sensitive and accurate assay to apply in pancreatic function tests involving duodenal content analysis.

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“…An increase in lactoferrin content in pure pancreatic juice and in the duodenal aspirate has been found in patients affected by chronic pancreatitis [3][4][5]. Although at first some pathogenetic role of this protein in chronic pancreatitis was suggested [6], this hypothesis was later denied; on the other hand, the presence of lactoferrin in the paro tid saliva of patients suffering from chronic pancreatitis and in patients with chronic pa rotiditis suggested that the increase in lacto ferrin in the pancreatic juice should be con sidered secondary to pancreatitis itself [7,8], Recently, it has been hypothesized [9] that increased lactofcrrin levels in the pancreatic juice of patients with chronic pancreatitis might reflect an increased autolytic activity (crinophagia) of the pancreatic cells, with the aim of destroying the excess of the zymogen granules. This increased activity could be due to an enhanced ductal back-pressure.…”

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confidence: 99%

Plasma Levels of Lactoferrin in Children Suffering from Cystic Fibrosis

Benini¹,

Agostini²,

Vaona³

et al. 1985

Digestion

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Plasma levels of lactoferrin (LF) have been found to be increased in a few patients with cystic fibrosis (CF). This study was aimed at investigating plasma LF levels in children with CF (26 cases) and in controls (C) (19 cases). Plasma LF was measured by a radioimmunoassay method. Plasma LF levels were not significantly different in CF and in C, even though 10 CF patients showed LF levels above the mean + 2 SD value of the controls. Neither the duration of the disease nor the age of the controls was correlated with LF or with the exocrine pancreatic capacity. A significant relationship between the presence of an acute lung inflammation and LF levels was found. This study shows that LF is increased in CF only in the presence of an acute inflammatory state. Further studies are necessary to establish the usefulness of an LF assay as an index of the presence of an acute inflammatory process.

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Salivary Secretion in Chronic Pancreatitis with Special Reference to Albumin and Lactoferrin

Cited by 8 publications

References 5 publications

Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids

Biochemical Composition of Human Saliva in Relation To Other Mucosal Fluids

Duodenal Lactoferrin in Patients with Chronic Pancreatitis and Gastrointestinal Diseases

Plasma Levels of Lactoferrin in Children Suffering from Cystic Fibrosis

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