Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health

Tabari, Zahra Alizadeh; Azadmehr, Abbas; Tabrizi, Mohammad; Hamissi, Jalaleddin; Ghaedi, Fatemeh Baharak

doi:10.5051/jpis.2013.43.5.227

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…Salivary samples were chosen for evaluation, as saliva is considered a diagnostic material, (18) abundant and has a simple sampling technique, fast and non-invasive; also, has no need for specialized equipment for its sampling. (19,20) The present study showed no statistically of visfatin in the present study showed cut-off values of 18.3 and 191.0 ng/ml, respectively. At these cutoff values, the diagnostic accuracy of visfatin as a marker for detecting OSCC and BEOLP is 100.0%.…”

Section: Discussioncontrasting

confidence: 56%

Evaluation of Salivary and Serum Visfatin in Oral Bullous Erosive Lichen Planus and Oral Squamous Cell Carcinoma

Moneim

Maged

Shaker

2017

Egyptian Dental Journal

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Introduction: Bullous Erosive Oral Lichen Planus (BEOLP) is a potentially malignant condition with high rate of transformation into Oral Squamous Cell Carcinoma (OSCC), and aiming to reduce the morbidity and mortality rate arising from OLP; the early diagnosis of oral cancer was recommended. Many biomarkers were found to be released into the serum and the saliva during the course of both diseases, BEOLP and OSCC. One of these proteins is visfatin.Aim of the study: The aim of this study was to evaluate salivary level of visfatin and to find out if it can be used instead of its serum level as an early diagnostic biomarker for patients with either BEOLP or OSCC. Subjects and Methods:The study was conducted on 3 groups; group (A) which included fifteen medically free subjects, group (B) which included fifteen patients suffering from BEOLP, and finally group (C) which included fifteen patients suffering from OSCC. Serum and salivary samples were collected and visfatin levels were measured using an ELISA kit (Enzyme Linked Immuno Sorbent Assay). Data were analyzed by SPSS. Results:The present study detected no statistically significant difference between mean visfatin levels in BEOLP and OSCC groups; both showed statistically significantly higher mean levels than control group which showed the lowest mean visfatin level. It Also revealed a statistically significant positive (direct) correlation between serum and salivary visfatin levels (r = 0.835, P-value <0.001) i.e. an increase in serum level of visfatin is associated with an increase in salivary level of Visfatin.Conclusion: Salivary level of visfatin can be used instead of its serum level as a biomarker for BEOLP and OSCC.

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Section: Discussioncontrasting

confidence: 56%

Evaluation of Salivary and Serum Visfatin in Oral Bullous Erosive Lichen Planus and Oral Squamous Cell Carcinoma

Moneim

Maged

Shaker

2017

Egyptian Dental Journal

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“…Periodontitis is one of the most frequent oral diseases. It is a very important health issue that affects the patients' quality of life [22]. Periodontitis is diagnosed by clinical and radiographic criteria, which are not sufficient in determining the activity of the disease and the patient's susceptibility to the disease progression.…”

Section: Resultsmentioning

confidence: 99%

“…In 2013, Tabari et al [22] show results similar to the current study: a significant increase of RANKL and RANKL/OPG ratio and a nonsignificant increase of OPG, but the salivary values of these biomarkers they reported are very different: 266 ± 48 pg/ml RANKL in the chronic periodontitis group, 207 ± 83 pg/ml RANKL for the healthy subjects, 2, 1 ± 1.0 pg/ml OPG in the CP group, and 2, 20 ± 7, 78 pg/ml OPG in the H group. Similar values as those of our study were reported by Hassan et al in 2015 [30], OPG 64, 5 ± 20, 9 pg/ml for the CP patients, and by Al-Ghurabi and Mohssen [31], in the same year, with a mean value for RANKL of 56, 8 pg/ml in the CP group.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis

Teodorescu

Mârțu

Teslaru

et al. 2019

Journal of Immunology Research

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RANKL (receptor activator of nuclear factor kappa-β ligand) and OPG (osteoprotegerin) are two proteins involved in bone remodelling. During the active phase of periodontal disease, an imbalance between the ratios of the two elements can be noticed. While the expression of RANKL is elevated compared with that of OPG, the RANKL is available to bond with RANK (receptor activator of nuclear factor kappa-β). This study was conducted on 41 patients: 19 with generalized aggressive periodontitis, 18 with severe chronic periodontitis, and 4 periodontal healthy subjects. For each patient included, we determined the salivary levels of RANKL and OPG with the help of two Human ELISA kits. The results show that the patients affected by periodontitis, either aggressive or chronic, have significant higher values of RANKL and RANKL/OPG ratio. This values correlate with the local inflammation status.

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“…Such results may also account for variant levels of subclinical inflammation among healthy subjects. Regarding salivary OPG levels, Tabari et al [ 44 ] failed to demonstrate a significant difference between healthy and CP patients while Costa et al [ 45 ] showed that it was higher in CP and diabetic patients than in the control group suggesting that OPG concentration could increase under circumstances that require the inhibition of osteoclastogenesis. Moreover, Garlet et al [ 15 ] observed equal prevalence of OPG expression in periodontitis patients and control, even a more intense expression was detected in the diseased group.…”

Section: Discussionmentioning

confidence: 99%

Effect of Periodontal Surgery on Osteoprotegerin Levels in Gingival Crevicular Fluid, Saliva, and Gingival Tissues of Chronic Periodontitis Patients

et al. 2015

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Objectives. This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). Subjects and Methods. The study included 30 subjects divided into 2 groups: 20 CP patients and 10 periodontally healthy subjects. Plaque index, gingival index, pocket depth, and clinical attachment level measurements were recorded for all subjects. GCF, salivary, and gingival samples were collected from all 30 subjects at baseline and 3 and 6 month after OFD from the 20 CP patients. GCF and salivary OPG levels were assessed by ELISA assay, while OPG expression in gingival tissues was examined by immunohistochemistry. Results. GCF, salivary and gingival OPG profiles were significantly higher in control subjects compared to CP patients at baseline (P < 0.001). Within CP group, OPG levels in GCF, saliva, and gingival samples showed a significant increase at 3 and 6 months after OFD (P < 0.001) compared to baseline. Although OPG values increased significantly in gingival samples and insignificantly in saliva after 3 months compared to 6 months, yet GCF levels were significantly decreased. Conclusions. OPG might be considered as a diagnostic and prognostic biomarker of periodontal bone destruction. This trial is registered with NCT02160613.

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Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health

Cited by 13 publications

References 29 publications

Evaluation of Salivary and Serum Visfatin in Oral Bullous Erosive Lichen Planus and Oral Squamous Cell Carcinoma

Evaluation of Salivary and Serum Visfatin in Oral Bullous Erosive Lichen Planus and Oral Squamous Cell Carcinoma

Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis

Effect of Periodontal Surgery on Osteoprotegerin Levels in Gingival Crevicular Fluid, Saliva, and Gingival Tissues of Chronic Periodontitis Patients

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