Salivary stimulation by prolonged release films of pilocarpine in diabetic rats.

Rodríguez, Jesús Israel; Sánchez, Rosa I.; Garza, Martha Leticia Cabello; Nakagoshi, María Argelia; Solís, Juan; Arévalo, Katiushka; Garza, Emmanuel

doi:10.17126/joralres.2015.022

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Recently there have been attemps to find an alternative for local treatment by means of prolonged-release biofilms of pilocarpine, that have shown a substantial increase in normal salivary flow in diabetic rats. Pilocarpine is controllably released for 4 hours and is biocompatible with adherent fibroblast cell line, however its effects have not been tested in humans 92 .…”

Section: Rodríguez J Martínez G Rodríguez N Chapa M and Solís Jmentioning

confidence: 99%

Dental perspective on Sjögren’s syndrome: literature review

et al. 2015

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Abstract:The human body releases around 500-600mL of saliva daily, however when values of unstimulated whole saliva range from 0.1 to 0.2mL/ min, there is a condition called Hyposalivation or hyposialia. Hyposalia is characterized by a large number of systemic conditions, including Sjögren's syndrome, a chronic autoimmune disease that affects between 0.1 and 3% of the world population and is characterized by exocrinopathy of the salivary glands leading to glandular hypofunction and thus decreasing the normal salivary flow. Saliva is part of innate immunity, when there is a decrease in protein secretion, numerous oral manifestations occur such as dental caries, candidiasis, gingival disease, angular cheilitis, lymphomas of the salivary glands, dysphagia, erythematous and fissured tongue, among others. Currently there is no defined dental treatment, however there are alternative treatments by sialogogues and salivary substitutes, plus non-pharmacological therapies, which seek to maintain the ecology and oral conditions stable, in addition to preventive and restorative dental treatment for lesions already established as a consequence of the disease. The aim of this study is to conduct a literature review on the characteristics, classification, oral manifestations and dental management of Sjögren's syndrome.

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Section: Rodríguez J Martínez G Rodríguez N Chapa M and Solís Jmentioning

confidence: 99%

Dental perspective on Sjögren’s syndrome: literature review

et al. 2015

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“…El SS puede presentarse de forma aislada como primario (Rodríguez et al, 2015b), o puede manifestarse como secundario al expresarse con otras enfermedades autoinmunes, tales como artritis reumatoide (Berkey & Scannapieco, 2013), lupus eritematoso sistémico, esclerosis, entre otras (Shahane & Patel, 2014).…”

Section: Introductionunclassified

Índice de Placa Bacteriana, Índice Gingival y Prueba de Silometría en Pacientes con Síndrome de Sjögren Primario y Secundario

Triana-Reyes

Martínez-Sandoval

Rodríguez-Franco

et al. 2021

Int. J. Odontostomat.

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“…15 They have also proved to be biocompatible and possess the best physicochemical properties for this type their administration.…”

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confidence: 99%

Salivary stimulation by prolonged release of pilocarpine in Sjögren’s syndrome.

et al. 2017

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Introduction: Prolonged drug delivery in the oral cavity offers many advantages, such as reducing adverse effects. Pilocarpine is an FDA-approved parasympathomimetic drug for the treatment of glandular hypofunction; however, its adverse effects limit its use. Objective: To evaluate the stimulation of salivary flow by the use of pilocarpine-releasing films, as well as their effects on the symptoms of xerostomia and adverse effects in patients with Sjögren's syndrome (SS). Materials and methods: Hy droxypropylmethylcellulose (Methocel K4MCR) films were prepared in 1% acetic acid and pilocarpine was added under magnetic stirring. The pH and thickness, as well as diffusion uniformity and kinetics of drug release per cm 2 were evaluated by spectrophotometry. The films were tested sublingually in 40 patients with Sjögren's syndrome for a period of two weeks. Changes in their salivary flow were evaluated by analyzing samples of total saliva. Additionally, patients were screened for symptoms of xerostomia and adverse effects. Results: The films had a pH of 2.91±0.035, a thickness of 0.06866±0.00152μm, and a diffusion uniformity of 91% per cm 2 . Use of the films resulted in an increase in salivary flow in both primary and secondary Sjö-gren's syndrome, but this increase was only significant in primary SS. Conclusion: Films showed optimal physicochemical properties for their administration, and proved effective in stimulating salivary flow without causing adverse effects during their administration.

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Salivary stimulation by prolonged release films of pilocarpine in diabetic rats.

Cited by 3 publications

References 8 publications

Dental perspective on Sjögren’s syndrome: literature review

Dental perspective on Sjögren’s syndrome: literature review

Índice de Placa Bacteriana, Índice Gingival y Prueba de Silometría en Pacientes con Síndrome de Sjögren Primario y Secundario

Salivary stimulation by prolonged release of pilocarpine in Sjögren’s syndrome.

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