Salivary-type hyperamylasemia in primary lung cancer: Observation of a possible precursor of the salivary-type isoamylase

Maeda, Mitsuo; Ōtsuki, Makoto; Yuu, Hosai; Satoh, Susumu; Yamasaki, Tohru; Baba, Shigeaki

doi:10.1016/0277-5379(82)90054-2

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…In our study, only 13 patients (18%) had slight hyperamylasaemia. Similar findings were obtained in series, reporting hyperamylasaemia in 6.5-10% of patients with lung cancer [5][6][7][8]. With the exception of series by TOMITA et al [5], these studies were not confined to resectable cases.…”

Section: Tumour Amylasesupporting

confidence: 81%

“…An association between increased serum amylase and lung carcinomas was first described in 1951, by WEISS et al [3]. Since then, several cases of hyperamylasaemia in patients with lung carcinomas have been published [4][5][6]. Biochemical analyses of tumour tissue, studies of cell cultures, immunohistochemical techniques, and Northern blot analyses support the theory that amylase is produced by carcinoma cells [4][5][6].…”

mentioning

confidence: 99%

“…Since then, several cases of hyperamylasaemia in patients with lung carcinomas have been published [4][5][6]. Biochemical analyses of tumour tissue, studies of cell cultures, immunohistochemical techniques, and Northern blot analyses support the theory that amylase is produced by carcinoma cells [4][5][6]. Hyperamylasaemia in lung cancer has usually been described in case reports, and only a few series have been published [5][6][7][8].…”

mentioning

confidence: 99%

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alpha-Amylase in resectable lung cancer

Lenler-Petersen¹,

Grove²,

Brock³

et al. 1994

Eur Respir J

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Biochemical analysis and immunohistochemical techniques support the theory that hyperamylasaemia in lung cancer is due to amylase production in carcinoma cells. The vast majority of amylase-producing carcinomas are adenocarcinomas with amylase isoenzyme similar to the salivary type. This prospective study assesses alpha-amylase expression in resectable lung cancer. Seventy four patients with resectable lung cancer were studied. Amylase activity in tumour tissue was analysed and isoamylase identification performed. Immunohistochemical analysis was performed using a polyclonal rabbit antibody against human salivary amylase. Hyperamylasaemia occurred in 13 out of 70 patients. Increased amylase activity in tumour tissue was found in 10 out of 52 cases, of which only two were associated with hyperamylasaemia. With the exception of one large cell carcinoma and one squamous cell carcinoma, the tumours were adenocarcinomas. Immunohistochemical analysis revealed amylase expression in seven adenocarcinomas and two adenosquamous carcinomas. In conclusion, immunohistochemical amylase expression was restricted to carcinomas with adenomatous differentiation. Biochemical analysis confirmed amylase production in 5 of 7 cases examined, the tissue amylase isoenzymes being of salivary type. However, hyperamylasaemia and a slightly increased amylase activity in tumour tissue may be caused by factors other than amylase-producing carcinoma cells.

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Section: Tumour Amylasesupporting

confidence: 81%

mentioning

confidence: 99%

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confidence: 99%

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alpha-Amylase in resectable lung cancer

Lenler-Petersen¹,

Grove²,

Brock³

et al. 1994

Eur Respir J

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“…Studies of tumor-producing amylase originated with Weiss et al's 1951 report illustrating a case of bronchogenic carcinoma associated with elevated serum amylase levels [1]. Since then, many reports have focused on lung cancer-producing amylase [2][3][4][5][6][7][8][9][10][11], and there have been similar reports in pancreatic [12], stomach [13], uterine [14], and ovarian cancers [15,16]. Moreover, there have been reports of non-epithelial amylase-producing osteosarcoma [17] and multiple myeloma [18][19][20].…”

Section: Review Of Related Literaturementioning

confidence: 99%

“…Many investigators have reported amylase-producing ovarian cancer and reported that serum amylase is an important tumor marker [15,[30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. In particular, amylase isoenzyme electrophoresis has been helpful [6,32] in making an early diagnosis and distinguishing from pancreatitis; the amylase phenotype was generally salivary. In contrast, there have been a few unique reports [30,40,44,45] describing acidic amylase and/or fast-migrating amylase found in the sera or ascites associated with ovarian cancer.…”

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confidence: 99%

Sialyl Salivary–Type Amylase Associated with Ovarian Cancer

Moriyama¹

2013

Cancer Treatment - Conventional and Innovative Approaches

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The criteria were: a S3 to S2 ratio of over 1.0 and/or acidic fast-migrated sub-bands from S4 to S6. The sera were stored at-80ºC until required. A sample with a normal amylase isoenzyme electrophoretic pattern was used as control in the analyses of neuraminidase treatment, reaction with anti-salivary monoclonal antibody, and size-exclusion HPLC. 2.2. Measurement of total amylase activity Total serum amylase activity was measured on a Hitachi 7170 automated analyzer with G4-CNP as substrate (Toyobo, Osaka, Japan) at 37ºC. The reference interval of total serum amylase activity was from 40 to 160 U/L.

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Ectopic production of salivary-type amylase by a lga-λ-type multiple myeloma

Hata¹,

Matsuzaki²,

Tanaka³

et al. 1988

Cancer

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A patient with IgA-lambda-type multiple myeloma who appeared to be secreting salivary-type amylase ectopically is reported. Both the patient's serum and urine contained high levels of amylase. Amylase activity in the supernatant of cultured myeloma cells, obtained from the patient's pleural effusion while he had malignant pleuritis, increased almost linearly from the time of cell seeding. The presence of IgA and S-type amylase in the myeloma cells was demonstrated cytochemically and by immunoelectron microscopy. These observations showed that amylase was produced by these human myeloma cells.

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Salivary-type hyperamylasemia in primary lung cancer: Observation of a possible precursor of the salivary-type isoamylase

Cited by 15 publications

References 13 publications

alpha-Amylase in resectable lung cancer

alpha-Amylase in resectable lung cancer

Sialyl Salivary–Type Amylase Associated with Ovarian Cancer

Ectopic production of salivary-type amylase by a lga-λ-type multiple myeloma

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