Salmonella: a continuing problem

Hardy, Anne

doi:10.1136/pgmj.2003.016584

Cited by 26 publications

(16 citation statements)

References 30 publications

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“…In contrast, enteric fever, caused by typhoid Salmonella, is associated with a high morbidity and mortality rate and occurs predominantly in underdeveloped countries (Hardy 2004).…”

Section: Epidemiologymentioning

confidence: 99%

Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance

Eng

Pusparajah

Mutalib

et al. 2015

Frontiers in Life Science

722

482

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Salmonella is one of the most frequently isolated foodborne pathogens. It is a major worldwide public health concern, accounting for 93.8 million foodborne illnesses and 155,000 deaths per year. To date, over 2500 Salmonella serotypes have been identified and more than half of them belong to Salmonella enterica subsp. enterica, which accounts for the majority of Salmonella infections in humans. Salmonella infections that involve invasive serotypes are often life threatening, necessitating appropriate and effective antibiotic therapy. The emergence of multi-drug-resistant (MDR) Salmonella serotypes is having a great impact on the efficacy of antibiotic treatment, and an increasing prevalence of MDR strains may lead to an increase in mortality rates of Salmonella infections. Epidemiological studies indicate that MDR Salmonella serotypes are more virulent than susceptible strains, as reflected by increased severity and more prolonged disease in patients infected by MDR strains. Preventive measures have been proposed to eliminate the spread of Salmonella infection. While the maintenance of effective food hygiene and water sanitation remain the cornerstones, additional measures such as restriction of indiscriminate use of antibiotics in food animals are important. This review provides an overview of Salmonella infection, and discusses the nomenclature, pathogenesis, clinical manifestations, epidemiology and antibiotic resistance of Salmonella.

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“…In contrast, enteric fever, caused by typhoid Salmonella, is associated with a high morbidity and mortality rate and occurs predominantly in underdeveloped countries (Hardy 2004).…”

Section: Epidemiologymentioning

confidence: 99%

Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance

Eng

Pusparajah

Mutalib

et al. 2015

Frontiers in Life Science

722

482

View full text Add to dashboard Cite

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“…In the early 1980s, PT4 overtook PT8 to become the predominant phage type in 1983, comprising 46% of isolations that year. By 1988 PT4 had risen to account for 81% of Salmonella Enteritidis strains isolated [16] and had ended the political career of a prominent government minister [21]. The United Kingdom was not alone; analysis of data submitted to the World Health Organization's Salmonella surveillance system showed that Salmonella Enteritidis in the late 1980s was increasing on several continents, with North America, South America, and Europe appearing to bear the brunt [22].…”

Section: A Brief History Of Nontyphoidal Salmonellosis In the United mentioning

confidence: 99%

The "Decline and Fall" of Nontyphoidal Salmonella in the United Kingdom

O’Brien

2012

Clinical Infectious Diseases

116

103

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“…Salmonella is Gram negative bacterium known worldwide as the causative agent of gastroenteritis, bacteremia and enteric fever . Majority of human gastroenteritis have been attributed to the consumption of Salmonella contaminated eggs and chicken meat .…”

Section: Introductionmentioning

confidence: 99%

Isolation and partial characterization of ΦSP‐1, a Salmonella specific lytic phage from intestinal content of broiler chicken

Augustine

Louis²,

Varghese³

et al. 2012

J. Basic Microbiol.

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Salmonella enterica subsp. enterica serovar Enteritidis is a major causative agent of gastroenteritis with contaminated eggs and chicken meat being the major source of infection. Phages are seriously being considered as a safe and cheaper alternative to antibiotics. The intestinal content of chicken was used as source for isolating phages. Phage designated as ΦSP‐1 was selected for the study. Transmission electron microscopy (TEM) of phage ΦSP‐1 revealed that it belonged to family Podoviridae. The optimal multiplicity of infection (MOI) was 5 phages/cell. Latent and rise period were calculated to be 30 and 55 minutes respectively, while burst size was 44 phages/bacterial cell. The genome size of ΦSP‐1 was estimated to be 86 kb from pulsed‐field gel electrophoresis analysis (PFGE). The effect of different physical and chemical parameters like temperature, pH, salinity and CaCl2 were analyzed to optimize the conditions for large scale production of phages and to check the viability of ΦSP‐1 under different physiochemical conditions. A temperature of 40 °C, pH 8 and 0.25 M NaCl were found to be optimum for phage adsorption and it was able to survive up to a temperature of 50 °C for 3 min. Capability to survive under hostile environmental conditions, absence of virulence genes in genome and genus specificity suggest suitability of ΦSP‐1 to be used as a biocontrol agent.

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Salmonella: a continuing problem

Cited by 26 publications

References 30 publications

Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance

Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance

The "Decline and Fall" of Nontyphoidal Salmonella in the United Kingdom

Isolation and partial characterization of ΦSP‐1, a Salmonella specific lytic phage from intestinal content of broiler chicken

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