Salmonella endocarditis presenting as cerebral hemorrhage

Gómez-Moreno, Julieta Berenice; Moar, C; Román, Francisco; Perez-Maestu, R.; Letona, J Martínez López de

doi:10.1016/s0953-6205(00)00060-1

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…The available vaccines for poultry in India are not very effective [3, 4]. The backyard poultry practices are very common in India so there is always a possibility of transfering of Salmonella Typhimurium from poultry to human populations where it can cause serious health problems [5, 6]. There is an emergent need of better vaccine for poultry against salmonellosis.…”

Section: Introductionmentioning

confidence: 99%

Cloning, Sequencing andIn SilicoAnalysis of Omp C ofSalmonellaTyphimurium

Jha

Kumar

Saxena

et al. 2012

ISRN Veterinary Science

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SalmonellaTyphimurium is an important pathogen having a broad host range. In human population it causes mostly gastroenteritis but there are reports in which it was found to be responsible to cause several lethal diseases like endocarditis and meningitis. Poultry products are the major sources of this organism in India as these are consumed at various stages of cooking. The available vaccines have their own limitations such as short-term immunity. Outer membrane proteins have shown some promising potential, so in the present study Omp C ofSalmonellaTyphimurium was cloned and sequenced to explore the possibility of development of r-DNA vaccine againstSalmonellaTyphimurium for poultry. The sequence of Omp C was studied for antigenic indexing, epitope mapping, and MHC mapping using various bioinformatic tools. The ORF analysis revealed a complete coding region of approximately 1000 bp. Five major and 13 minor B-cell epitopes were identified having an antigenic index of 1.7. The sequences also showed major histocompatibility complex (MHC) class I and class II binding region indicating a potential of eliciting cell-mediated immune response. The findings indicate that Omp C may be proven as promising candidate for development of r-DNA vaccine againstSalmonellaTyphimurium.

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Section: Introductionmentioning

confidence: 99%

Cloning, Sequencing andIn SilicoAnalysis of Omp C ofSalmonellaTyphimurium

Jha

Kumar

Saxena

et al. 2012

ISRN Veterinary Science

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“…To identify potential adverse effects of direct pathogen exposure, we performed a phenome-scan across the 197 cardiovascular, hematologic, neurologic, and respiratory traits as described above. Our top gene-phenotype pairs include: 1) FAM171B, our most significant association with interleukin 13 (IL-13) levels is also associated with alveolar and parietoalveolar pneumonopathy (p = 4.04x10 -5 ), a phenotype known to be modulated by IL-13 dependent signaling (Zheng et al, 2008); 2) OSBPL10, the most significant gene associated with cell death caused by Salmonella enterica serovar Typhimurium, is also associated with intracerebral hemorrhage (p = 4.99x10 -5 ), a known complication of S. Typhimurium endocarditis (Gómez-Moreno et al, 2000). These data highlight the utility of joint genetic analysis of pathogenexposure-induced phenotypes and clinical ID traits to gain insights into the molecular and cellular basis of complications and adverse outcomes.…”

Section: Phenome Scan Of Twas Findings From Hi-hostmentioning

confidence: 99%

The genetic architecture of human infectious diseases and pathogen-induced cellular phenotypes

Hale

Zhou

Sale

et al. 2020

Preprint

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Infectious diseases (ID) represent a significant proportion of morbidity and mortality across the world. Host genetic variation is likely to contribute to ID risk and downstream clinical outcomes, but there is a need for a genetics-anchored framework to decipher molecular mechanisms of disease risk, infer causal effect on potential complications, and identify instruments for drug target discovery. Here we perform transcriptome-wide association studies (TWAS) of 35 clinical ID traits in a cohort of 23,294 individuals, identifying 70 gene-level associations with 26 ID traits. Replication in two large-scale biobanks provides additional support for the identified associations. A phenome-scale scan of the 70 gene-level associations across hematologic, respiratory, cardiovascular, and neurologic traits proposes a molecular basis for known complications of the ID traits. Using Mendelian Randomization, we then provide causal support for the effect of the ID traits on adverse outcomes. The rich resource of genetic information linked to serologic tests and pathogen cultures from bronchoalveolar lavage, sputum, sinus/nasopharyngeal, tracheal, and blood samples (up to 7,699 positive pathogen cultures across 92 unique genera) that we leverage provides a platform to interrogate the genetic basis of compartment-specific infection and colonization. To accelerate insights into cellular mechanisms, we develop a TWAS repository of gene-level associations in a broad collection of human tissues with 79 pathogen-exposure induced cellular phenotypes as a discovery and replication platform. Cellular phenotypes of infection by 8 pathogens included pathogen invasion, intercellular spread, cytokine production, and pyroptosis. These rich datasets will facilitate mechanistic insights into the role of host genetic variation on ID risk and pathophysiology, with important implications for our molecular understanding of potentially severe phenotypic outcomes.

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