Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever

Crump, John A.; Oo, Win Thandar

doi:10.1016/s0140-6736(21)01340-4

Cited by 2 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inactivated Salmonella was developed as a human vaccine, but it only provides protection against acute infection, and it induces symptoms like fever, headache and asthenia, which raises concerns about its safety [ 34 , 35 ]. Vi polysaccharide is a kind of widely applied human Salmonella subunit vaccines, and several commercially available Vi polysaccharide vaccines play important roles in preventing severe symptoms and containing Salmonella epidemic among undeveloped countries [ 36 ]. However, since S. Typhimurium has no capsule, the susceptible hosts could hardly benefit from Vi polysaccharide vaccination.…”

Section: Discussionmentioning

confidence: 99%

The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium

Zuo,

Yang,

et al. 2024

Vaccines

View full text Add to dashboard Cite

Salmonella Typhimurium (S. Typhimurium) is a zoonotic pathogen posing a threat to animal husbandry and public health. Due to the emergence of antibiotic-resistant strains, alternative prevention and control strategies are needed. Live attenuated vaccines are an ideal option that provide protection against an S. Typhimurium pandemic. To develop a safe and effective vaccine, double-gene mutations are recommended to attenuate virulence. In this study, we chose aroA and luxS genes, whose deletion significantly attenuates S. Typhimurium’s virulence and enhances immunogenicity, to construct the double-gene mutant vaccine strain SAT52ΔaroAΔluxS. The results show that the mutant strain’s growth rate, adherence and invasion of susceptible cells are comparable to a wild-type strain, but the intracellular survival, virulence and host persistence are significantly attenuated. Immunization assay showed that 106 colony-forming units (CFUs) of SAT52ΔaroAΔluxS conferred 100% protection against wild-type challenges; the bacteria persistence in liver and spleen were significantly reduced, and no obvious pathological lesions were observed. Therefore, the double-gene mutant strain SAT52ΔaroAΔluxS exhibits potential as a live attenuated vaccine candidate against S. Typhimurium infection.

show abstract

Section: Discussionmentioning

confidence: 99%

The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium

Zuo,

Yang,

et al. 2024

Vaccines

View full text Add to dashboard Cite

show abstract

“…Different from Ty21a, the Vi capsular polysaccharide vaccine acts through the activation of T-cell-independent IgG antibody production and has an efficacy of 55%, with cumulative immunity up to 3 years through a single dose [430]. The administration of a S. Typhi Vi polysaccharide with the tetanus toxoid conjugate vaccine (Tybar) vaccine has shown to have an efficacy of up to 85% in children under the age of 2 years, with a high increase in T-cell-independent IgG production [431]. Similarly, another Vi-polysaccharide based Vi Conjugate (Vi-CRM 197 ) and Vi Conjugate (Vi-rEPA) vaccine has demonstrated up to 90% efficacy in children and a similar increase in IgG production lasting up to 4 years post-vaccination against S. Typhi [432,433].…”

Section: Bacteriophagesmentioning

confidence: 99%

Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections

Lamichhane,

Mawad,

Saleh

et al. 2024

Antibiotics

View full text Add to dashboard Cite

Salmonella is a major foodborne pathogen and a leading cause of gastroenteritis in humans and animals. Salmonella is highly pathogenic and encompasses more than 2600 characterized serovars. The transmission of Salmonella to humans occurs through the farm-to-fork continuum and is commonly linked to the consumption of animal-derived food products. Among these sources, poultry and poultry products are primary contributors, followed by beef, pork, fish, and non-animal-derived food such as fruits and vegetables. While antibiotics constitute the primary treatment for salmonellosis, the emergence of antibiotic resistance and the rise of multidrug-resistant (MDR) Salmonella strains have highlighted the urgency of developing antibiotic alternatives. Effective infection management necessitates a comprehensive understanding of the pathogen’s epidemiology and transmission dynamics. Therefore, this comprehensive review focuses on the epidemiology, sources of infection, risk factors, transmission dynamics, and the host range of Salmonella serotypes. This review also investigates the disease characteristics observed in both humans and animals, antibiotic resistance, pathogenesis, and potential strategies for treatment and control of salmonellosis, emphasizing the most recent antibiotic-alternative approaches for infection control.

show abstract

Salmonella Typhi Vi polysaccharide conjugate vaccine protects infants and children against typhoid fever

Cited by 2 publications

References 11 publications

The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium

The aroA and luxS Double-Gene Mutant Strain Has Potential to Be a Live Attenuated Vaccine against Salmonella Typhimurium

Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections

Contact Info

Product

Resources

About