2013
DOI: 10.1186/1471-2180-13-236
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Salmonella Typhimurium TTSS-2 deficient mig-14 mutant shows attenuation in immunocompromised mice and offers protection against wild-type Salmonella Typhimurium infection

Abstract: BackgroundDevelopment of Salmonella enterica serovar Typhimurium (S. Typhimurium) live attenuated vaccine carrier strain to prevent enteric infections has been a subject of intensive study. Several mutants of S. Typhimurium have been proposed as an effective live attenuated vaccine strain. Unfortunately, many such mutant strains failed to successfully complete the clinical trials as they were suboptimal in delivering effective safety and immunogenicity. However, it remained unclear, whether the existing live a… Show more

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Cited by 10 publications
(6 citation statements)
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References 54 publications
(53 reference statements)
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“…For these studies, we used two different routes of infection: intra-gastric (IG) as well as intra-peritoneal (IP). Animals that were IG infected were pretreated with 50 mg of streptomycin in order to overcome the competition of gut luminal microbiota 15 . Mice were infected with EB-247 and S .…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…For these studies, we used two different routes of infection: intra-gastric (IG) as well as intra-peritoneal (IP). Animals that were IG infected were pretreated with 50 mg of streptomycin in order to overcome the competition of gut luminal microbiota 15 . Mice were infected with EB-247 and S .…”
Section: Resultsmentioning
confidence: 99%
“…The mice infection experiments were performed in specific pathogen free BALB/c mice as mentioned earlier 15 . Infections of mice were conducted in individual ventilated cages.…”
Section: Methodsmentioning
confidence: 99%
“…The double mutant of ssaV gene and other essential SPI1-T3SS or auxotrophic genes were attenuated enough to be used as vaccines for typhoid (Kirkpatrick et al, 2006;Pati et al, 2013a;2013b), as a carrier to deliver heterologous antigens (Hegazy and Hensel, 2014;Michael et al, 2010) or to induce chemokines (Li et al, 2009b).…”
Section: Discussionmentioning
confidence: 99%
“…Since the structural and secreted effectors of many other pathogens have been identified as immunogenic, the presence of several secretion systems in Bcc provides many possible immunogenic targets for a subunit vaccine [ 34 ]. Their presence also allows for many mutation candidates for the generation of a live attenuated vaccines [ 34 , 35 ].…”
Section: Bcc Virulence Factorsmentioning
confidence: 99%