Salt pan brine water as a sustainable source of sulphated polysaccharides with immunostimulatory activity

Nunes, Cláudia; Rocha, Adriana; Quitério, Pedro; Ferreira, Sónia S.; Correia, Alexandra; Vilanova, Manuel; Coimbra, Manuel A.

doi:10.1016/j.ijbiomac.2019.04.021

Cited by 6 publications

(1 citation statement)

References 36 publications

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“…Even so, the B-cell activation induced with Ppt_CaCl 2 was significantly lower than that observed for Sn_CaCl 2 , F2, or F3 fractions, suggesting that FCSPs have a higher activation capacity than alginates. The presence of sulphate esters in the polysaccharides, as occurs in FCSPs, has been reported to be relevant for immunostimulatory activity [ 39 , 40 ]. On the other hand, co-extracted laminarans in Sn_CaCl 2 had no negative impact on B-cell activation promoted by FCSPs.…”

Section: Resultsmentioning

confidence: 99%

Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities

et al. 2023

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Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure–function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and evaluate their immunostimulatory and hypocholesterolemic activities, helping to pinpoint a structure–activity relationship. Alginate, laminarans (F1, neutral glucose-rich polysaccharides), and two fractions (F2 and F3) of FCSPs (negatively charged) were studied. Whereas F2 is rich in uronic acids (45 mol%) and fucose (29 mol%), F3 is rich in fucose (59 mol%) and galactose (21 mol%). These two fractions of FCSPs showed immunostimulatory activity on B lymphocytes, which could be associated with the presence of sulphate groups. Only F2 exhibited a significant effect in reductions in in vitro cholesterol’s bioaccessibility attributed to the sequestration of bile salts. Therefore, S. latissima FCSPs were shown to have potential as immunostimulatory and hypocholesterolemic functional ingredients, where their content in uronic acids and sulphation seem to be relevant for the bioactive and healthy properties.

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Section: Resultsmentioning

confidence: 99%