Salting-out precipitation of cocarboxylase hydrochloride from aqueous solution by addition of acetone

Abstract

Ind. Eng. Chem. Prod. Res. deamination reaction followed by a hydrogenation of butene(s) to give butane. Andreu, P.; Rosa-Brush, M.; Sanchez, C.; Nolier, H. Satterfield, C. N. Ind. Eng. Chem. Process Des. Dev. Giuskoter, H. J. Fuel 1965, 44, 285. 1976, 15, 272. D~v . 1086, 25, 657-664 657 Hogan, P.; Pasek, J. Collect. Czech. Chem. Comm. 1973, 38, 1513. Hogan, P.; Pasek. J. Collect. Czech. Chem. Comm. 1974, 39. 3696. Katzer, J. R.; Sivasubramanian, R. Catal. Rev.-Sci. Eng. 1979, 20, 155. Liu, K. H. D.; Hamrln, C. E., Jr. Ind. Eng. Chem. Process Des. Dev. 1983, Liu, K. H. D.; Johannes, A. H.; Hamrin, C. E., Jr. Fuel 1984, 63, 18. Lycourghiotis, A.; Katsanos, N. A.; Vattis, D. J. Chem. SOC., Faraday Trans. McIivrled, H. 0. Ind. Eng. Chem, Process Des. Dev. 1971, 10, 125. Pasek. J. Collect. Czech. Chem. Comm. 1963, 2 8 , 1007. Pasek. J.; Tyrpeki, J.; Machova, M. Collect. Czech. Chem. Comm. 1966, Sakata, Y.; Hamrln, C. E.. Jr. Fuel 1983, 62, 508. Satterfield, C. N.; Modell. M.; Hltes, R. A.; Declerck, C. J. Ind. Eng. Chem. Shih, S. S.; Katzer, J. R.; Kwart, H.; Stiles, A. B. Prep.-Am. Chem. Soc.,Redpitation of cocarboxylase hydrochloride from aqueous solution induced by addition of acetone was investigated. The corrected separation density concept, bulk density, the results of screening, and the electron microscope observations have been used to study the effect of the acetone addition rate, initial concentration, the amount of seeds, and the intensity of mixing on the quality of precipitate agglomerates. A set of experimentally verified optimum conditions for the process yielding the product of desired quality was established. Experimental SectionEquilibria. The knowledge of the solubility of a given substance is a prerequisite to investigate the crystallization. The solubility for the system CX-HC1-water-acetone a t 15 "C was determined in the following simple experiment. An acid solution of CX-HC1 and water of a known composition was placed in an Erlenmeyer flask, and a known Long-acting androgens are potentlaliy useful as male contraceptives and to maintain libido and potency under certain pathological conditions. This paper describes the synthesis of esters of testosterone with four bile acids as part of a World Health Organization Program for the synthesis and screening of potential longacting contraceptive agents. Two methods of esterification were fwnd to give optimum resutts of yield and purity of the final product: (a) reaction of the acid chloride with the thallium(1) salt of the steroidal alcohol and (b) reaction of the free acid with testosterone in the presence of 4-(dimethylamino)pyridine and dicyclohexylcarbodiimide.

Potassium sulfate water-alcohols systems: composition and density of saturated solutions

“…Apparatus and Procedure. The experimental equipment and method of operation were as described previously (7,4). 0021-9568/90/1735-0216$02.50/0 Pressure was maintained constant to within 0.02 kPa, and the equilibrium temperature was measured in a digital thermometer (Comark, Model 6800), giving a reading of ±0.01 K and whose mean error was estimated to be 0.01 % of the reading.…”

“…In continuation of our vapor-liquid equilibrium (VLE) studies on ester + alkanol binary mixtures (7-4), we present here VLE measurements at 101.32 kPa for methyl butanoate + ethanol or + 1-propanol. Another aim of this paper is to compare the experimental data with those predicted with the ASOG model (OH/COO, Kojima and Tochigi ( 5)) and the different values for the ester group from the classical UNIFAC model (COH/COO, Fredenslund et al (6); OH/COOC, Skjold-Jorgensen et al (7); CCOH/COOC, Fredenslund et al ( 8)).…”

Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles

“…Various experimental studies of antisolvent crystallization in an agitated semibatch vessel indicate that the crystal size distribution (CSD) depends strongly on operating conditions such as agitation rate, mode of addition (direct or reverse), addition rate, solvent composition, and size of the crystallizer [3,[19][20][21][22][23][24][25][26][27][28][29][30][31]. The polymorphic or pseudopolymorphic form can also depend on the operating conditions [32][33][34][35][36][37].…”

Growth kinetics of potassium chloride II—Water–ethanol systems

“…Hence, the influence of organic molecules on the mechanisms of spontaneous nucleation and on the crystal habit of the precipitates thus obtained has been investigated by a number of researchers [1][2][3][4][5][6][7]. Comparatively, much less attention has been devoted to the effect of the cosolvents upon the crystallization mechanisms and growth kinetics of inorganic seed crystals [8].…”