Salvage Chemotherapy for Refractory Transitional Cell Carcinoma of the Ovary (TCC)

Sweeten, Keri M.; Gershenson, David M.; Burke, Thomas W.; Morris, Mitchell; Levenback, Charles; Silva, Elvio G.

doi:10.1006/gyno.1995.0010

Cited by 15 publications

(7 citation statements)

References 3 publications

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“…Transitional cell carcinomas (TCCs) are relatively rare neoplasms in the gynecologic tract. They occur most commonly in the ovary,1‐4 but they have also been observed more recently in the cervix5‐7 and endometrium8‐10 as well as in the fallopian tube,11, 12 broad ligament,13 and a paratubal cyst 14. Noninvasive extraovarian transitional cell lesions have also been observed in the female genital tract 5…”

mentioning

confidence: 99%

Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium

Lininger

Wistuba

Gazdar

et al. 1998

Cancer

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BACKGROUND The etiologic role of human papillomavirus (HPV) in a variety of squamous neoplasms, including malignant and premalignant lesions of the cervix, is well established. The presence of HPV, predominantly HPV types 16 and 18, in adenocarcinomas of the endometrium has also been reported, although less commonly. Although rare, transitional cell carcinoma (TCC) in the female genital tract, including such sites as the cervix, endometrium, and ovary, has been described. HPV, however, has not been previously studied in TCC of the female genital tract, the etiology of which is uncertain. METHODS Eight cases of primary TCC of the endometrium and six cases of primary TCC of the cervix were retrieved from the files of the Armed Forces Institute of Pathology and the University of Texas Southwestern Medical Center. Slides stained with hematoxylin and eosin were reviewed, and tumor tissue was obtained and analyzed for the presence of HPV types 6, 11, 16, 18, 31, and 33 by polymerase chain reaction (PCR). RESULTS HPV was detected by PCR in 4 of 6 TCCs of the cervix (67%) and in 2 of 8 TCCs of the endometrium (25%), using HPV general primers and specific primers to HPV type 16. PCR for HPV using specific primers to HPV types 6 and 11, 18, 31, and 33 were negative in all cases. CONCLUSIONS The results of this study demonstrated that HPV type 16 was present in a proportion of primary TCCs of the cervix and endometrium. These findings support the hypothesis that these rare neoplasms are similar, with regard to risk factors, to the more commonly occurring squamous cell carcinomas of the cervix, and suggest that HPV may play an etiologic role in at least a proportion of these tumors. Cancer 1998;83:521‐527. © 1998 American Cancer Society.

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confidence: 99%

Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium

Lininger

Wistuba

Gazdar

et al. 1998

Cancer

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“…In addition, given the large number of patients identified, we were able to define the unique demographic and clinical characteristics of patients with TC-variant. In addition, compared with most previous case-control studies, 9,15,[17][18][19] most patients with TC-variant (84%) were diagnosed after 1998, thus their management had been more contemporary and possibly all surgically treated patients received platinumbased chemotherapy. However, limitations of the present study include the lack of information on specific chemotherapy regimens used.…”

Section: Discussionmentioning

confidence: 98%

“…10 Increased sensitivity to first-line platinumbased chemotherapy has also been observed in other studies 9,15 and seems to be present even in the refractory setting. 19 The molecular mechanism responsible for the documented increased chemosensitivity has yet to be fully elucidated. Given that SEER database does not provide information on chemosensitivity, we could not verify its effect on patient survival but we can strongly speculate that it may contribute to the survival benefit.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Transitional Cell Carcinoma-Like Morphology of High-Grade Serous Ovarian Carcinoma: A Comparative Study

Nasioudis

Sisti

Kanninen

et al. 2016

Int J Gynecol Cancer

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“…TCC of the ovary is reported to be sensitive to cisplatin-based chemotherapy and has a better prognosis than other types of common epithelial tumors of the ovary. Sweeten et al suggested that TCC may be more chemosensitive than other common epithelial tumors in the refractory setting [8]. …”

Section: Discussionmentioning

confidence: 99%

Transitional cell carcinoma of the ovary: A rare case and review of literature

et al. 2010

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IntroductionTransitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer.Case presentationA 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. Abdominal computed tomography showed a pelvic mass. CA-125 was normal. A staging operation with total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy and pelvic lymph node dissection was performed. After surgery, the pathologic report of the right ovarian tumour was TCC, grade 3, stage IC. The patient underwent 3 cycles of chemotherapy: carboplatin and paclitaxel. She is regularly followed up and has been disease free for 10 monthsConclusionTransitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient outcomes after chemotherapy are better than for other types of ovarian cancers.

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Salvage Chemotherapy for Refractory Transitional Cell Carcinoma of the Ovary (TCC)

Cited by 15 publications

References 3 publications

Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium

Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium

Prognostic Significance of Transitional Cell Carcinoma-Like Morphology of High-Grade Serous Ovarian Carcinoma: A Comparative Study

Transitional cell carcinoma of the ovary: A rare case and review of literature

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