Salvage of Distal Flap Necrosis by Topical Superoxide Dismutase

Suzuki, Shigehiko; Matsushita, Yoji; Isshiki, Nobuhiko; Hamanaka, Hiroshi

doi:10.1097/00000637-199109000-00009

Cited by 19 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…34,35) Studies of the topical application of compounds with free radical scavenging properties on patients or animals have been shown to significantly improve wound healing and protect tissues from oxidative damage. [27][28][29][36][37][38][39] In this study, H 2 O 2 and HX-XO generated O 2 Ϫ were employed as an in vitro model to cause cultured skin cell injury, in which the protective effect of the C. odorata extract fractions were assessed.…”

Section: Discussionmentioning

confidence: 99%

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

Phan

Wang

See

et al. 2001

Biological & Pharmaceutical Bulletin

187

122

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

Phan

Wang

See

et al. 2001

Biological & Pharmaceutical Bulletin

187

122

View full text Add to dashboard Cite

“…Occurrence of necrosis may be attributed to the metabolic, anatomic, and haemodynamic changes in the flap [1][2][3]. Numerous experimental and clinical studies have been performed to improve flap viability by alternating the pathological changes in flap metabolism occurring after elevation [4][5][6][7][8][9][10][11]. Phosphodiesterase type 5 (PDE5) is an enzyme that is responsible for the degradation of cyclic 3',5'-guanosine monophosphate (cGMP).…”

mentioning

confidence: 99%

Comparison of the effects of systemic sildenafil, tadalafil, and vardenafil treatments on skin flap survival in rats

Kaya

Çerkez

Işılgan

et al. 2015

Journal of Plastic Surgery and Hand Surgery

View full text Add to dashboard Cite

show abstract

“…8) Numerous studies have successfully applied antioxidants for protection against flap necrosis and other related complications. 7,[9][10][11][12][13][14] Various natural antioxidants significantly improve flap survival. 11,[15][16][17] Strategic therapeutic approaches with antioxidants have been used to reduce the oxidative stress effects of diabetes.…”

mentioning

confidence: 99%

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Bağdaş

Etoz

Inan

et al. 2014

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

There has been considerable interest in understanding the effects of antioxidants in flap survival during diabetes. Previous studies showed that chlorogenic acid (CGA) exhibits potent antioxidant effects. We aimed to determine the effects of systemic CGA treatment on skin flap survival in an experimental random-pattern dorsal skin flap model in diabetic rats. Twenty-eight male Wistar rats were divided into four groups: phosphate buffered saline (PBS)-treated or CGA-treated nondiabetic rats, PBS-treated or CGA-treated diabetic rats. Diabetes was induced by streptozotocin (45 mg/kg). Caudally based bipedicled dorsal skin flaps were elevated. CGA (100 mg/kg) or PBS (mL/kg; as vehicle) was administered intraperitoneally once daily. On postoperative day 7, flap survival, regional blood perfusion and microangiography were evaluated. The malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels were evaluated from the flap tissue. Capillary density and vascular endothelial growth factor (VEGF) expression were assessed. Harmful effects of diabetes on flap survival were observed. CGA attenuated these effects and allowed greater survival and blood perfusion. CGA decreased MDA and NO levels and increased GSH and SOD levels. CGA elevated capillary density and VEGF expression. This study showed that peripherally administered CGA significantly improved flap survival in diabetic and nondiabetic rats.Key words antioxidant; chlorogenic acid; diabetes; dorsal skin flap; flap survival; oxidative stress Skin flaps are widely used in the repair of local tissue loss and the reconstruction of several tissue defects. Flap necrosis is frequently observed in flap tissues in the postoperative period and is an unwanted effect of healing. Many factors are known to play a role in this major complication such as ischemia, inadequate blood flow and disturbed venous drainage.

show abstract

Salvage of Distal Flap Necrosis by Topical Superoxide Dismutase

Cited by 19 publications

References 0 publications

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

Phenolic Compounds of Chromolaena odorata Protect Cultured Skin Cells from Oxidative Damage: Implication for Cutaneous Wound Healing.

Comparison of the effects of systemic sildenafil, tadalafil, and vardenafil treatments on skin flap survival in rats

Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats

Contact Info

Product

Resources

About