Salvage transoral laser microsurgery for early recurrent glottic carcinoma after primary laser treatment

Abstract

Thirty-six rT1 and 14 rT2 lesions were treated with salvage TLM. Mean follow-up was 68.3 months. Thirty-one patients were cured by first salvage TLM and four by further laser procedures. The other 15 patients were finally salvaged by laryngectomy or radiotherapy. Five-year overall survival, disease-specific survival, local control, and loco-regional control rates were 89.9%, 97.9%, 62.3%, and 60.1%, respectively. Larynx preservation rate after long-term follow-up was 86%. In univariate analysis, second local recurrence showed a statistically significant impact on disease-specific survival rate ( p = 0.049) and larynx preservation rate ( p = 0.006). In multivariate analysis, it was associated with a statistically significant decrease in larynx preservation rate ( p = 0.016). There was no statistically significant difference in oncological results between patients with and without anterior commissure involvement.

Salvage transoral laser microsurgery for recurrent glottic carcinoma after primary laser-assisted treatment: Analysis of prognostic factors

“…In our patients treated with salvage TLM for glottic recurrences (33 cases), the final organ preservation and ultimate locoregional control rates were 100% and 96%, respectively. These results sound good by comparison with other reported series of glottic recurrences treated with salvage TLM, 7,15 and this is probably because of our strict criteria for deciding which patients are eligible for this procedure. The low sample size in the present study requires caution in interpreting the results, but these data suggest potential factors that could inform treatment and follow-up decisions for patients with recurrent glottic carcinoma after primary TLM.…”

Transoral Laser Microsurgery in Early Glottic Lesions

“…Huang analyzed 50 rT1–T2 lesions treated with salvage TLM and found local control to be 70% with a larynx preservation of 88% and disease-specific survival of 98%. A second recurrence after salvage TLM significantly impacted larynx preservation and disease-specific survival causing the author to argue for oncological safe resection margins in salvage TLM rather than sparing healthy tissue for a good voice outcome [76]. …”

Salvage surgery for head and neck squamous cell carcinoma

“…For recurrent early glottic tumors, treated with salvage tlM, five-year overall survival, disease-specific survival, local control and locoregional control rates have been shown to be 89.9, 97.9, 62.3 and 60.1 %, respectively (n = 50). the larynx preservation rate at long-term followup was 86 % [40].…”