Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2

Liu, Miao; Xu, Hanying; Zhang, Ling; Zhang, Cai; Yang, Liancheng; Ma, Enlong; Liu, Lianqing; Li, Yanchun

doi:10.1016/j.bbrc.2017.11.014

Cited by 46 publications

(27 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies indicated that increased oxidative stress is an important cause of oxaliplatin-induced hepatotoxicity ( 11 , 21 , 25 ). As the end-product of lipid breakdown, MDA is recognized as a reliable indicator sensitive to oxidative stress in hepatic lesions ( 42 ). The present study demonstrated that MgiG eliminated the changes in oxidative stress indicators (GSH and MDA) caused by oxaliplatin exposure.…”

Section: Discussionmentioning

confidence: 99%

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

et al. 2018

View full text Add to dashboard Cite

Oxaliplatin is a core chemotherapeutic agent used for the treatment of colorectal liver metastasis; however, liver injury caused by oxaliplatin increases the risk of peri-operative morbidity and mortality. Magnesium isoglycyrrhizinate (MgiG) is a magnesium salt of 18-α glycyrrhizic acid stereo-isomer that has demonstrated liver-protective effects against toxins and hepatitis. In the present study, the liver-protective effect of MgiG against oxaliplatin-induced hepatic injury was examined in vitro and in vivo. The results demonstrated that MgiG had a protective effect against oxaliplatin-induced liver injury, as evidenced by the alleviation of hepatic pathological damage and transaminase levels. The protective effect of MgiG was demonstrated to be correlated with inhibition of oxidative stress, the interleukin-6 pathway and the coagulation system. Altogether, the present findings suggested that MgiG may have potential value in the clinical prevention and treatment of oxaliplatin-induced liver injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Salvianolic acid B ( 25 ) inhibited PQ-induced activation of the transforming growth factor- β (TGF- β 1)/Smad3 pathway, which was a key regulator of pulmonary fibrosis [ 99 ]. The capability of 25 in activating Nrf2 and inhibiting pulmonary fibrosis was further confirmed by a MRC-5 human lung fibroblast cell model and a bleomycin-induced rat pulmonary fibrosis model [ 100 ].…”

Section: Nrf2-based Therapeutic Potential Of Smrr and Its Constitumentioning

confidence: 99%

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2‐Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Jiao

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Oxidative stress plays a central role in the pathogenesis of many human diseases. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the intracellular antioxidant response and is an emerging target for the prevention and therapy of oxidative stress-related diseases. Salviae Miltiorrhizae Radix et Rhizoma (SMRR) is a traditional Chinese medicine (TCM) and is commonly used for the therapy of cardiac cerebral diseases. Cumulative evidences indicated that the extract of SMRR and its constituents, represented by lipophilic diterpenoid quinones and hydrophilic phenolic acids, were capable of activating Nrf2 and inhibiting oxidative stress. These bioactive constituents demonstrated a therapeutic potential against human diseases, exemplified by cardiovascular diseases, neurodegenerative diseases, diabetes, nephropathy, and inflammation, based on the induction of Nrf2-mediated antioxidant response and the inhibition of oxidative stress. In the present review, we introduced the SMRR and Nrf2 signaling pathway, summarized the constituents with an Nrf2-inducing effect isolated from SMRR, and discussed the molecular mechanism and pharmacological functions of the SMRR extract and its constituents.

show abstract

“…Sal B has the molecular formula of C36H30O16, an important water-soluble active ingredient in Salvia miltiorrhiza, and possesses most of the biological activity of Salvia miltiorrhiza [9]. Studies have shown that Sal B has been extensively used in various diseases, such as angina pectoris, pulmonary fibrosis and malignancies [10][11][12]. Sal B is most commonly used for treatment of cardiovascular disease, such as myocardial infarction and heart failure [9,13,14]; however, the roles of Sal B in improving PE and related mechanisms underlying it remain elusive.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms underlying the improvement of preeclampsia through salvianolic acid B-regulated miRNA-155/CXCR4

2020

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects and mechanisms of salvianolic acid B (Sal B) in preeclampsia treatment by in vivo and in vitro study. Material and methods: Rats were randomly divided into 5 groups. In order to establish the model of preeclampsia, endotoxin was administered to the rats in the Sal B intervention and model groups. The systolic blood pressure (SBP) of the tail artery and urine protein concentration were observed at different points, the miRNA-155 and CXCR4 gene expression levels by RT-PCR and the CXCR4 and p-AKT protein expression by WB assay. Using HTR8/ SVneo to explain the mechanisms; evaluating the miRNA-155 and CXCR4 mRNA expression by RT-PCR assay, measuring the cell invasion and migration by transwell and wound healing assay in different groups; evaluating the CXCR4 and p-AKT protein expression by WB assay and p-AKT nucleation volume by cellular immunofluorescence were evaluated. Results: Compared with the normal group, the systolic blood pressure and urine protein were significantly increased in the model group (p < 0.05), serum NO concentration was significantly down-regulated (all p < 0.05), CXCR4 and miRNA-155 mRNA expression was significantly different and CXCR4 and p-AKT protein expression was significantly suppressed (all p < 0.05). With Sal B supplement, the SBP, urine protein and NO concentration were significantly improved with dose-dependent (all p < 0.05). In the cell experiment, the cell invasion and migration ability were significantly improved with Sal B supplement (both p < 0.05). However, with miRNA-155 transfection, the cell invasion and migration ability were suppressed with Sal B treatment (both p < 0.05). Conclusions: Sal B improved preeclampsia via regulation of miRNA-155/ CXCR4 in the in vitro and vivo study.

show abstract

Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2

Cited by 46 publications

References 17 publications

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2‐Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Mechanisms underlying the improvement of preeclampsia through salvianolic acid B-regulated miRNA-155/CXCR4

Contact Info

Product

Resources

About