Salzmann Nodular Degeneration

Graue-Hernández, Enrique O; Mannis, Mark J.; Eliasieh, Kasra; Greasby, Tamara A.; Beckett, Laurel A.; Bradley, Jay; Schwab, Ivan R.

doi:10.1097/ico.0b013e3181b7658d

Cited by 43 publications

(53 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Graue-Hernandez et al [16] that predominantly white women were affected in the sixth decade of life within their 180 retrospective SND cases. Recently, Eberwein et al [17] elucidated the epithelial nature of Salzmann nodules by analysis of limbal and central corneal epithelial markers.…”

Section: Discussionmentioning

confidence: 97%

Superficial keratectomy, PTK, and mitomycin C as a combined treatment option for Salzmann's nodular degeneration: a follow-up of eight eyes

Khaireddin

Katz

Baile³

et al. 2011

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Our follow-up and the small treatment numbers are not sufficient to finally prove the superiority of the combined treatment modality (superficial keratectomy, PTK, and MMC) for SND, but the results of our study are promising. Longer follow-up and a larger cohort are warranted for proving MMC to be an effective, successful, and safe method in the armamentarium for treating and preventing Salzmann degeneration.

show abstract

Section: Discussionmentioning

confidence: 97%

Superficial keratectomy, PTK, and mitomycin C as a combined treatment option for Salzmann's nodular degeneration: a follow-up of eight eyes

Khaireddin

Katz

Baile³

et al. 2011

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…The underlying pathogenesis of Salzmann nodular degeneration is not well-understood, although it is thought to occur as a result of chronic ocular surface irritation and likely represents a common end point for a variety of ocular conditions 4 5 8. Some authors have speculated that exacerbation of dry eye syndrome contributes to the formation of Salzmann nodules after LASIK 1 2.…”

Section: Discussionmentioning

confidence: 99%

Salzmann nodular degeneration associated with epithelial ingrowth after LASIK treated with superficial keratectomy

Stem

Hood

2015

BMJ Case Reports

View full text Add to dashboard Cite

SUMMARYA 41-year-old woman who underwent uncomplicated LASIK and two subsequent flap lifts for epithelial ingrowth of the right eye became progressively symptomatic with blurred vision, photophobia and foreign body sensation over the ensuing 5 years. Clinical examination of the right eye demonstrated extensive epithelial ingrowth around the flap periphery with overlying Salzmann nodules in the same distribution. Similar findings were not present in the left eye. Anterior segment optical coherence tomography demonstrated subclinical flap elevation in the areas of epithelial ingrowth, which may have predisposed to nodule development due to a dellen effect. The patient underwent superficial keratectomy with significant improvement of her symptoms. BACKGROUND

show abstract

“…GraueHernandez et al described 108 patients with 180 eyes with Salzmann nodular degeneration. 16 They concluded that this entity remains of uncertain aetiology in which inflammation may have a role. The new international classification on corneal dystrophies therefore does not classify SN to any group of corneal dystrophies.…”

Section: Discussionmentioning

confidence: 99%

Peripheral hypertrophic subepithelial corneal degeneration presenting with bilateral nasal and temporal corneal changes

Schargus

Kusserow

Schlötzer‐Schrehardt

et al. 2014

Eye

View full text Add to dashboard Cite

Purpose To characterise the history, clinical and histopathological features of patients with bilateral nasal and temporal peripheral hypertrophic subepithelial corneal degeneration in a German population. Methods A detailed ophthalmological and dermatological history and clinical findings were recorded of nine patients with bilateral simultaneous nasal and temporal peripheral corneal degeneration from two centers in Germany. Excised tissues were studied by histopathology, immunohistochemistry, and transmission electron microscopy. Results Foreign body sensation and need of artificial tear substitutes were the only symptoms reported regularly. Schirmer's and Jones-test were normal in all, but fluorescein break-up time of 410 s was found in five eyes of four patients. Best corrected visual acuity was reduced only under glare conditions. Corneal topography revealed irregular astigmatism in 13 of 14 eyes. Follow-up median time was 35 months. Most cases were stable within the follow-up period. Light and electron microscopy revealed the findings of superficial vascularised corneal hypertrophic scars, oxytatlan fibers, and discontinued Bowmans layer. Conclusion In this series of German patients with peripheral hypertrophic subepithelial corneal degeneration, the changes were predominantly located in the palpebral aperture and often present in both eyes. No associated surface disease could be established in this study. Light and transmission electron microscopy showed histological features that are similar to Salzmann's corneal changes without any inflammation. We hypothesise that light exposure and a localised limbal insufficiency could be involved in the pathogenesis.

show abstract

Salzmann Nodular Degeneration

Cited by 43 publications

References 17 publications

Superficial keratectomy, PTK, and mitomycin C as a combined treatment option for Salzmann's nodular degeneration: a follow-up of eight eyes

Superficial keratectomy, PTK, and mitomycin C as a combined treatment option for Salzmann's nodular degeneration: a follow-up of eight eyes

Salzmann nodular degeneration associated with epithelial ingrowth after LASIK treated with superficial keratectomy

Peripheral hypertrophic subepithelial corneal degeneration presenting with bilateral nasal and temporal corneal changes

Contact Info

Product

Resources

About