Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder

Koeppel, Carina J.; Herrmann, Theresa; Weidner, Kerstin; Linn, Jennifer

doi:10.1016/j.nicl.2021.102731

Cited by 6 publications

(4 citation statements)

References 66 publications

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“…49 For example, patients with depression show increased connectivity in the DMN. 50,51 FNC was significantly decreased in the prefrontal region of the DMN and increased in the hippocampus in glioma patients, which was associated with tumor grade. 52 The results of our study indicate that the left MSFG (extending to the right MSFG) of the DMN was lower in the DON group than in HCs, suggesting that decreased FNC in the DMN is related to dysfunctional emotional cognition in DON.…”

Section: Intra-and Internetwork Comparisons Of Fncmentioning

confidence: 90%

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Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Wei,

Lin,

et al. 2024

CNS Neurosci Ther

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AimsThis study aimed to investigate the resting‐state functional connectivity and topologic characteristics of brain networks in patients with diabetic optic neuropathy (DON).MethodsResting‐state functional magnetic resonance imaging scans were performed on 23 patients and 41 healthy control (HC) subjects. We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.ResultsCompared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN‐L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.ConclusionDON patients altered node properties and connectivity in the DMN, auditory network, FPN‐L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.

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Section: Intra-and Internetwork Comparisons Of Fncmentioning

confidence: 90%

“…Altered connectivity in the DMN have been linked to mental disorders 49 . For example, patients with depression show increased connectivity in the DMN 50,51 . FNC was significantly decreased in the prefrontal region of the DMN and increased in the hippocampus in glioma patients, which was associated with tumor grade 52 .…”

Section: Discussionmentioning

confidence: 99%

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Wei,

Lin,

et al. 2024

CNS Neurosci Ther

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“…Further analysis showed that the structural connectivity between the left anterior cingulate gyrus and the left orbital gyrus in DMN increased with the severity of the disease. As the synergy of the left cingulate gyrus increased, multiple areas of the network were damaged, and the overall network was eventually affected [19]. In ECN, the connectivity between the left anterior cingulate gyrus and the right orbital gyrus increased with the severity of the disease, and gradually spread the damage to the frontal lobe [16].…”

Section: Discussionmentioning

confidence: 99%

“…In task-positive systems, the default mode network (DMN) [13][14][15] and the executive control network (ECN) [16,17] are two major networks closely related to depression, and the default network has always been considered to be related to the severity of MDD at rest [18]. DMN is one of the most prestigious brain networks and mainly includes the frontal lobe, cingulate gyrus and parietal lobe [19]. ECN mainly includes the lateral prefrontal cortex, cingulate gyrus and posterior parietal cortex [16].…”

Section: Introductionmentioning

confidence: 99%

Disrupted default mode network and executive control network are associated with depression severity on structural network

Cheng

Chu

et al. 2022

NeuroReport

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Objective Major depressive disorder (MDD) is a psychiatric disorder with a relatively limited response to treatment. It is necessary to better understand the neuroanatomical mechanisms of structural networks. MethodsThe current study recruited 181 first-onset, untreated adult MDD patients: slight MDD (SD, N = 23), moderate MDD (MD, N = 77), Heavy MDD (HD, N = 81) groups; along with a healthy control group (HC, N = 81) with matched general clinical data. FreeSurfer was used to preprocess T1 images for gray matter volume (GMV), and the default mode network (DMN) and the execution control network (ECN) were analyzed by structural covariance network (SCN). ResultsPresent study found that the GMV of brain regions reduced with the severity of the disease. Specifically, the GMV of the left anterior cingulate gyrus (ACC.L) is negatively correlated with MDD severity. In addition, the SCN connectivity of the whole-brain network increases with the increase of severity in MDD. ACC.L is a key brain region with increased connectivity between the left orbitofrontal in DMN and between the right orbitofrontal in ECN, which leads to damage to the balance of neural circuits. ConclusionsPatients with smaller GMV of ACC.L are more likely to develop severe MDD, and as a key region in both networks which have distinct structural network models in DMN and ECN. MDD patients with different severity have different neuroimaging changes in DMN and ECN.

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Social Anhedonia: (f)MRI Studies

Melnikov

2023

Neurosci Behav Physi

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Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder

Cited by 6 publications

References 66 publications

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting‐state functional magnetic resonance imaging study

Disrupted default mode network and executive control network are associated with depression severity on structural network

Social Anhedonia: (f)MRI Studies

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