Sample pre-treatment and analytical methodology for the simultaneous determination of pharmaceuticals and personal care products in sewage sludge

Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy

“…The reported values were considered acceptable for trace analysis of target analytes in a solid matrix such as sludge. Moreover, these values were similar to, or even lower than, values obtained in analogue multicomponent methods based on gas chromatography coupled to mass spectrometry (GC-MS) [12,24] and even LC-MS/MS [23,27].…”

“…Sample pre-treatment for the offline SPE methodological version was based on Argüeso-Mata et al, 2021 [21] and Perez-Lemus et al, [12], with further optimization to fully adapt the methodology to the matrices and analytes of the present study. Hence, 1) An exact amount of freeze-dried DS (~0.3 g) was placed in a plastic centrifuge tube (50 mL), spiked with 200 µL of a methanolic solution containing all the isotopically labelled internal standards at 0.5 mg L -1 , and then, homogenized.…”

“…In addition, large quantities of disposable material and organic solvents are employed. In the last years, alternatives have been developed which instrumentalist SPE and even couple it to the chromatographic section [12][13][14][15][16][17]. However, their implementation in the routine analysis labs is still scarce.…”

Experimental design approaches to optimize ultrasound-assisted simultaneous-silylation dispersive liquid–liquid microextraction for the rapid determination of parabens in water samples

“…To evaluate the performance of the UASS-DLLME, the linearity, limits of detection (LODs), limits of quantication (LOQs), precision, accuracy, selectivity, carryover effect and matrix effect of the developed method were validated based on protocols that were previously reported elsewhere. 23,24 All experimental data was obtained under the optimum conditions.…”

Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor

“…PPCPs pollution mainly comes from the effluent of wastewater treatment plants, pharmaceuticals, and livestock wastewater activities and is constantly introduced into the environment . It has been discovered that some PPCPs frequently occurred in soil, , sea, , river, − and even in tap water. − Worse still, PPCPs are difficult to be degraded and along with long-term accumulation, it is unavoidable that the PPCPs would become increasingly harmful to the biological environment and health …”